SH3BP1 (SH3 domain binding protein 1)

2018-11-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
ARHGAP43
FUSION GENES

Other Information

Locus ID:

NCBI: 23616
MIM: 617368
HGNC: 10824
Ensembl: ENSG00000100092

Variants:

dbSNP: 23616
ClinVar: 23616
TCGA: ENSG00000100092
COSMIC: SH3BP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100092ENST00000417536Q9Y3L3
ENSG00000100092ENST00000643339A0A2R8Y5V0
ENSG00000100092ENST00000649107A0A3B3IU28
ENSG00000100092ENST00000649765Q9Y3L3
ENSG00000100092ENST00000649765A0A2X0SFX7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
228912602012Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.30
232235682013A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation.9
248415632014An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling.9
269339172016SH3-domain binding protein 1 in the tumor microenvironment promotes hepatocellular carcinoma metastasis through WAVE2 pathway.6
287865072018SH3BP1-induced Rac-Wave2 pathway activation regulates cervical cancer cell migration, invasion, and chemoresistance to cisplatin.3

Citation

Dessen P

SH3BP1 (SH3 domain binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57617/sh3bp1