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SH3GLB2 (SH3-domain GRB2-like endophilin B2)

Identity

Alias_namesSH3-domain, GRB2-like, endophilin B2
Alias_symbol (synonym)KIAA1848
Other aliasPP6569
PP9455
RRIG1
HGNC (Hugo) SH3GLB2
LocusID (NCBI) 56904
Atlas_Id 73209
Location 9q34.11  [Link to chromosome band 9q34]
Location_base_pair Starts at 131770072 and ends at 131790632 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EIF4G2 (11p15.3) / SH3GLB2 (9q34.11)OCIAD1 (4p11) / SH3GLB2 (9q34.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SH3GLB2   10834
Cards
Entrez_Gene (NCBI)SH3GLB2  56904  SH3-domain GRB2-like endophilin B2
AliasesPP6569; PP9455; RRIG1
GeneCards (Weizmann)SH3GLB2
Ensembl hg19 (Hinxton)ENSG00000148341 [Gene_View]  chr9:131770072-131790632 [Contig_View]  SH3GLB2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000148341 [Gene_View]  chr9:131770072-131790632 [Contig_View]  SH3GLB2 [Vega]
ICGC DataPortalENSG00000148341
TCGA cBioPortalSH3GLB2
AceView (NCBI)SH3GLB2
Genatlas (Paris)SH3GLB2
WikiGenes56904
SOURCE (Princeton)SH3GLB2
Genetics Home Reference (NIH)SH3GLB2
Genomic and cartography
GoldenPath hg19 (UCSC)SH3GLB2  -     chr9:131770072-131790632 -  9q34.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SH3GLB2  -     9q34.11   [Description]    (hg38-Dec_2013)
EnsemblSH3GLB2 - 9q34.11 [CytoView hg19]  SH3GLB2 - 9q34.11 [CytoView hg38]
Mapping of homologs : NCBISH3GLB2 [Mapview hg19]  SH3GLB2 [Mapview hg38]
OMIM609288   
Gene and transcription
Genbank (Entrez)AB058751 AF257319 AF258589 AF370426 AF370433
RefSeq transcript (Entrez)NM_001287045 NM_001287046 NM_020145
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)SH3GLB2
Cluster EST : UnigeneHs.460238 [ NCBI ]
CGAP (NCI)Hs.460238
Alternative Splicing GalleryENSG00000148341
Gene ExpressionSH3GLB2 [ NCBI-GEO ]   SH3GLB2 [ EBI - ARRAY_EXPRESS ]   SH3GLB2 [ SEEK ]   SH3GLB2 [ MEM ]
Gene Expression Viewer (FireBrowse)SH3GLB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56904
GTEX Portal (Tissue expression)SH3GLB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NR46   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NR46  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NR46
Splice isoforms : SwissVarQ9NR46
PhosPhoSitePlusQ9NR46
Domaine pattern : Prosite (Expaxy)BAR (PS51021)    SH3 (PS50002)   
Domains : Interpro (EBI)AH/BAR-dom    BAR_dom    SH3_domain    SH3GLB2   
Domain families : Pfam (Sanger)BAR (PF03114)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam03114    pfam14604   
Domain families : Smart (EMBL)BAR (SM00721)  SH3 (SM00326)  
Conserved Domain (NCBI)SH3GLB2
DMDM Disease mutations56904
Blocks (Seattle)SH3GLB2
SuperfamilyQ9NR46
Human Protein AtlasENSG00000148341
Peptide AtlasQ9NR46
HPRD15334
IPIIPI00024540   IPI00398828   IPI00925205   IPI00435916   IPI00435919   IPI00878250   IPI00894363   IPI00893721   IPI00922456   
Protein Interaction databases
DIP (DOE-UCLA)Q9NR46
IntAct (EBI)Q9NR46
FunCoupENSG00000148341
BioGRIDSH3GLB2
STRING (EMBL)SH3GLB2
ZODIACSH3GLB2
Ontologies - Pathways
QuickGOQ9NR46
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytoplasm  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytoplasm  
Pathways : BIOCARTACBL mediated ligand-induced downregulation of EGF receptors [Genes]   
Pathways : KEGGEndocytosis   
NDEx NetworkSH3GLB2
Atlas of Cancer Signalling NetworkSH3GLB2
Wikipedia pathwaysSH3GLB2
Orthology - Evolution
OrthoDB56904
GeneTree (enSembl)ENSG00000148341
Phylogenetic Trees/Animal Genes : TreeFamSH3GLB2
HOVERGENQ9NR46
HOGENOMQ9NR46
Homologs : HomoloGeneSH3GLB2
Homology/Alignments : Family Browser (UCSC)SH3GLB2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSH3GLB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SH3GLB2
dbVarSH3GLB2
ClinVarSH3GLB2
1000_GenomesSH3GLB2 
Exome Variant ServerSH3GLB2
ExAC (Exome Aggregation Consortium)SH3GLB2 (select the gene name)
Genetic variants : HAPMAP56904
Genomic Variants (DGV)SH3GLB2 [DGVbeta]
DECIPHER (Syndromes)9:131770072-131790632  ENSG00000148341
CONAN: Copy Number AnalysisSH3GLB2 
Mutations
ICGC Data PortalSH3GLB2 
TCGA Data PortalSH3GLB2 
Broad Tumor PortalSH3GLB2
OASIS PortalSH3GLB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSH3GLB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSH3GLB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SH3GLB2
DgiDB (Drug Gene Interaction Database)SH3GLB2
DoCM (Curated mutations)SH3GLB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SH3GLB2 (select a term)
intoGenSH3GLB2
Cancer3DSH3GLB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609288   
Orphanet
MedgenSH3GLB2
Genetic Testing Registry SH3GLB2
NextProtQ9NR46 [Medical]
TSGene56904
GENETestsSH3GLB2
Huge Navigator SH3GLB2 [HugePedia]
snp3D : Map Gene to Disease56904
BioCentury BCIQSH3GLB2
ClinGenSH3GLB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56904
Chemical/Pharm GKB GenePA35740
Clinical trialSH3GLB2
Miscellaneous
canSAR (ICR)SH3GLB2 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSH3GLB2
EVEXSH3GLB2
GoPubMedSH3GLB2
iHOPSH3GLB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:43:05 CET 2017

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