SH3RF1 (SH3 domain containing ring finger 1)

2011-10-01  

Identity

HGNC
SH3RF1
LOCATION
4q32.3
LOCUSID
57630
ALIAS
POSH,RNF142,SH3MD2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57630
MIM: 618642
HGNC: 17650
Ensembl: ENSG00000154447

Variants:

dbSNP: 57630
ClinVar: 57630
TCGA: ENSG00000154447
COSMIC: SH3RF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154447ENST00000284637Q7Z6J0
ENSG00000154447ENST00000502315D6RHX5
ENSG00000154447ENST00000510806D6RAL3
ENSG00000154447ENST00000511421H0YA90

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
94827361998A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways.55
156595492005The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production.34
145042842003Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex.24
215861382011Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH.14
193930812009Exploring the functional interaction between POSH and ALIX and the relevance to HIV-1 release.13
197100102009POSH stimulates the ubiquitination and the clathrin-independent endocytosis of ROMK1 channels.13
236447442013Imputation-based association analyses identify new lung cancer susceptibility variants in CDK6 and SH3RF1 and their interactions with smoking in Chinese populations.4
281294442017Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels.3
209741342010POSH promotes cell survival in Drosophila and in human RASF cells.2

Citation

Dessen P

SH3RF1 (SH3 domain containing ring finger 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52411/sh3rf1