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SH3RF1 (SH3 domain containing ring finger 1)

Identity

Alias_namesSH3MD2
SH3 multiple domains 2
Alias_symbol (synonym)POSH
RNF142
KIAA1494
Other alias
HGNC (Hugo) SH3RF1
LocusID (NCBI) 57630
Atlas_Id 52411
Location 4q32.3  [Link to chromosome band 4q32]
Location_base_pair Starts at 169094256 and ends at 169271098 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SH3RF1 (4q32.3) / CMAS (12p12.1)SH3RF1 (4q32.3) / PPP6R3 (11q13.2)SH3RF1 (4q32.3) / SH3RF1 (4q32.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SH3RF1   17650
Cards
Entrez_Gene (NCBI)SH3RF1  57630  SH3 domain containing ring finger 1
AliasesPOSH; RNF142; SH3MD2
GeneCards (Weizmann)SH3RF1
Ensembl hg19 (Hinxton)ENSG00000154447 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154447 [Gene_View]  chr4:169094256-169271098 [Contig_View]  SH3RF1 [Vega]
ICGC DataPortalENSG00000154447
TCGA cBioPortalSH3RF1
AceView (NCBI)SH3RF1
Genatlas (Paris)SH3RF1
WikiGenes57630
SOURCE (Princeton)SH3RF1
Genetics Home Reference (NIH)SH3RF1
Genomic and cartography
GoldenPath hg38 (UCSC)SH3RF1  -     chr4:169094256-169271098 -  4q32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SH3RF1  -     4q32.3   [Description]    (hg19-Feb_2009)
EnsemblSH3RF1 - 4q32.3 [CytoView hg19]  SH3RF1 - 4q32.3 [CytoView hg38]
Mapping of homologs : NCBISH3RF1 [Mapview hg19]  SH3RF1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB040927 AK021429 AK025255 AK026726 BC033203
RefSeq transcript (Entrez)NM_020870
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SH3RF1
Cluster EST : UnigeneHs.301804 [ NCBI ]
CGAP (NCI)Hs.301804
Alternative Splicing GalleryENSG00000154447
Gene ExpressionSH3RF1 [ NCBI-GEO ]   SH3RF1 [ EBI - ARRAY_EXPRESS ]   SH3RF1 [ SEEK ]   SH3RF1 [ MEM ]
Gene Expression Viewer (FireBrowse)SH3RF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57630
GTEX Portal (Tissue expression)SH3RF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z6J0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z6J0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z6J0
Splice isoforms : SwissVarQ7Z6J0
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ7Z6J0
Domaine pattern : Prosite (Expaxy)SH3 (PS50002)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)SH3_domain    SH3RF1    Znf_C3HC4_RING-type    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)SH3_1 (PF00018)    SH3_9 (PF14604)    zf-C3HC4 (PF00097)   
Domain families : Pfam (NCBI)pfam00018    pfam14604    pfam00097   
Domain families : Smart (EMBL)RING (SM00184)  SH3 (SM00326)  
Conserved Domain (NCBI)SH3RF1
DMDM Disease mutations57630
Blocks (Seattle)SH3RF1
SuperfamilyQ7Z6J0
Human Protein AtlasENSG00000154447
Peptide AtlasQ7Z6J0
HPRD15335
IPIIPI00893844   IPI00893739   IPI00966916   IPI00967311   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z6J0
IntAct (EBI)Q7Z6J0
FunCoupENSG00000154447
BioGRIDSH3RF1
STRING (EMBL)SH3RF1
ZODIACSH3RF1
Ontologies - Pathways
QuickGOQ7Z6J0
Ontology : AmiGOprotein binding  Golgi apparatus  cytosol  apoptotic process  zinc ion binding  protein ubiquitination  transferase activity  lamellipodium  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of JNK cascade  perinuclear region of cytoplasm  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotein binding  Golgi apparatus  cytosol  apoptotic process  zinc ion binding  protein ubiquitination  transferase activity  lamellipodium  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of JNK cascade  perinuclear region of cytoplasm  negative regulation of extrinsic apoptotic signaling pathway  
NDEx NetworkSH3RF1
Atlas of Cancer Signalling NetworkSH3RF1
Wikipedia pathwaysSH3RF1
Orthology - Evolution
OrthoDB57630
GeneTree (enSembl)ENSG00000154447
Phylogenetic Trees/Animal Genes : TreeFamSH3RF1
HOVERGENQ7Z6J0
HOGENOMQ7Z6J0
Homologs : HomoloGeneSH3RF1
Homology/Alignments : Family Browser (UCSC)SH3RF1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSH3RF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SH3RF1
dbVarSH3RF1
ClinVarSH3RF1
1000_GenomesSH3RF1 
Exome Variant ServerSH3RF1
ExAC (Exome Aggregation Consortium)SH3RF1 (select the gene name)
Genetic variants : HAPMAP57630
Genomic Variants (DGV)SH3RF1 [DGVbeta]
DECIPHERSH3RF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSH3RF1 
Mutations
ICGC Data PortalSH3RF1 
TCGA Data PortalSH3RF1 
Broad Tumor PortalSH3RF1
OASIS PortalSH3RF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSH3RF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSH3RF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SH3RF1
DgiDB (Drug Gene Interaction Database)SH3RF1
DoCM (Curated mutations)SH3RF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SH3RF1 (select a term)
intoGenSH3RF1
Cancer3DSH3RF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenSH3RF1
Genetic Testing Registry SH3RF1
NextProtQ7Z6J0 [Medical]
TSGene57630
GENETestsSH3RF1
Target ValidationSH3RF1
Huge Navigator SH3RF1 [HugePedia]
snp3D : Map Gene to Disease57630
BioCentury BCIQSH3RF1
ClinGenSH3RF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57630
Chemical/Pharm GKB GenePA134915904
Clinical trialSH3RF1
Miscellaneous
canSAR (ICR)SH3RF1 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSH3RF1
EVEXSH3RF1
GoPubMedSH3RF1
iHOPSH3RF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:55:23 CEST 2017

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