Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SH3YL1 (SH3 and SYLF domain containing 1)

Identity

Alias_namesSH3 domain containing
Alias_symbol (synonym)Ray
DKFZP586F1318
Other aliasRAY
HGNC (Hugo) SH3YL1
LocusID (NCBI) 26751
Atlas_Id 54618
Location 2p25.3  [Link to chromosome band 2p25]
Location_base_pair Starts at 218136 and ends at 264097 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CPSF6 (12q15) / SH3YL1 (2p25.3)ROCK2 (2p25.1) / SH3YL1 (2p25.3)SH3YL1 (2p25.3) / SH3YL1 (2p25.3)
cytochrome_b () / SH3YL1 (2p25.3)CPSF6 12q15 / SH3YL1 2p25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)SH3YL1   29546
Cards
Entrez_Gene (NCBI)SH3YL1  26751  SH3 and SYLF domain containing 1
AliasesRAY
GeneCards (Weizmann)SH3YL1
Ensembl hg19 (Hinxton)ENSG00000035115 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000035115 [Gene_View]  chr2:218136-264097 [Contig_View]  SH3YL1 [Vega]
ICGC DataPortalENSG00000035115
TCGA cBioPortalSH3YL1
AceView (NCBI)SH3YL1
Genatlas (Paris)SH3YL1
WikiGenes26751
SOURCE (Princeton)SH3YL1
Genetics Home Reference (NIH)SH3YL1
Genomic and cartography
GoldenPath hg38 (UCSC)SH3YL1  -     chr2:218136-264097 -  2p25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SH3YL1  -     2p25.3   [Description]    (hg19-Feb_2009)
EnsemblSH3YL1 - 2p25.3 [CytoView hg19]  SH3YL1 - 2p25.3 [CytoView hg38]
Mapping of homologs : NCBISH3YL1 [Mapview hg19]  SH3YL1 [Mapview hg38]
OMIM617314   
Gene and transcription
Genbank (Entrez)AK026507 AK026586 AK055801 AK096440 AK123829
RefSeq transcript (Entrez)NM_001159597 NM_001282682 NM_001282687 NM_015677
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SH3YL1
Cluster EST : UnigeneHs.731436 [ NCBI ]
CGAP (NCI)Hs.731436
Alternative Splicing GalleryENSG00000035115
Gene ExpressionSH3YL1 [ NCBI-GEO ]   SH3YL1 [ EBI - ARRAY_EXPRESS ]   SH3YL1 [ SEEK ]   SH3YL1 [ MEM ]
Gene Expression Viewer (FireBrowse)SH3YL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26751
GTEX Portal (Tissue expression)SH3YL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96HL8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96HL8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96HL8
Splice isoforms : SwissVarQ96HL8
PhosPhoSitePlusQ96HL8
Domaine pattern : Prosite (Expaxy)SH3 (PS50002)   
Domains : Interpro (EBI)SH3_domain    SYLF_SH3YL1-like    Ysc84_actin-binding   
Domain families : Pfam (Sanger)SH3_1 (PF00018)    Ysc84 (PF04366)   
Domain families : Pfam (NCBI)pfam00018    pfam04366   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)SH3YL1
DMDM Disease mutations26751
Blocks (Seattle)SH3YL1
PDB (SRS)2D8H   
PDB (PDBSum)2D8H   
PDB (IMB)2D8H   
PDB (RSDB)2D8H   
Structural Biology KnowledgeBase2D8H   
SCOP (Structural Classification of Proteins)2D8H   
CATH (Classification of proteins structures)2D8H   
SuperfamilyQ96HL8
Human Protein AtlasENSG00000035115
Peptide AtlasQ96HL8
HPRD15336
IPIIPI00395699   IPI00893448   IPI00872745   IPI00892785   IPI00182774   IPI00969575   IPI00892546   IPI00892861   IPI00892986   IPI01010719   
Protein Interaction databases
DIP (DOE-UCLA)Q96HL8
IntAct (EBI)Q96HL8
FunCoupENSG00000035115
BioGRIDSH3YL1
STRING (EMBL)SH3YL1
ZODIACSH3YL1
Ontologies - Pathways
QuickGOQ96HL8
Ontology : AmiGOprotein binding  phosphatidylinositol biosynthetic process  phosphatase binding  ruffle membrane  phosphatidylinositol binding  regulation of ruffle assembly  
Ontology : EGO-EBIprotein binding  phosphatidylinositol biosynthetic process  phosphatase binding  ruffle membrane  phosphatidylinositol binding  regulation of ruffle assembly  
NDEx NetworkSH3YL1
Atlas of Cancer Signalling NetworkSH3YL1
Wikipedia pathwaysSH3YL1
Orthology - Evolution
OrthoDB26751
GeneTree (enSembl)ENSG00000035115
Phylogenetic Trees/Animal Genes : TreeFamSH3YL1
HOVERGENQ96HL8
HOGENOMQ96HL8
Homologs : HomoloGeneSH3YL1
Homology/Alignments : Family Browser (UCSC)SH3YL1
Gene fusions - Rearrangements
Fusion : MitelmanCPSF6/SH3YL1 [12q15/2p25.3]  [t(2;12)(p25;q15)]  
Fusion : MitelmanROCK2/SH3YL1 [2p25.1/2p25.3]  [t(2;2)(p25;p25)]  
Fusion: TCGACPSF6 12q15 SH3YL1 2p25.3 LUAD
Fusion Cancer (Beijing)cytochrome_b [SH3YL1]  -  2p25.3 [FUSC002938]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSH3YL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SH3YL1
dbVarSH3YL1
ClinVarSH3YL1
1000_GenomesSH3YL1 
Exome Variant ServerSH3YL1
ExAC (Exome Aggregation Consortium)SH3YL1 (select the gene name)
Genetic variants : HAPMAP26751
Genomic Variants (DGV)SH3YL1 [DGVbeta]
DECIPHERSH3YL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSH3YL1 
Mutations
ICGC Data PortalSH3YL1 
TCGA Data PortalSH3YL1 
Broad Tumor PortalSH3YL1
OASIS PortalSH3YL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSH3YL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSH3YL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SH3YL1
DgiDB (Drug Gene Interaction Database)SH3YL1
DoCM (Curated mutations)SH3YL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SH3YL1 (select a term)
intoGenSH3YL1
Cancer3DSH3YL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617314   
Orphanet
MedgenSH3YL1
Genetic Testing Registry SH3YL1
NextProtQ96HL8 [Medical]
TSGene26751
GENETestsSH3YL1
Target ValidationSH3YL1
Huge Navigator SH3YL1 [HugePedia]
snp3D : Map Gene to Disease26751
BioCentury BCIQSH3YL1
ClinGenSH3YL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26751
Chemical/Pharm GKB GenePA128394643
Clinical trialSH3YL1
Miscellaneous
canSAR (ICR)SH3YL1 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSH3YL1
EVEXSH3YL1
GoPubMedSH3YL1
iHOPSH3YL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:30:57 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.