SHB (SH2 domain containing adaptor protein B)

2016-10-01  

Identity

HGNC
LOCATION
9p13.1
LOCUSID
ALIAS
bA3J10.2
FUSION GENES

Other Information

Locus ID:

NCBI: 6461
MIM: 600314
HGNC: 10838
Ensembl: ENSG00000107338

Variants:

dbSNP: 6461
ClinVar: 6461
TCGA: ENSG00000107338
COSMIC: SHB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107338ENST00000377707Q15464

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
165696692006Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth.21
117865452002SH2-Bbeta is a Rac-binding protein that regulates cell motility.20
120840692002Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.8
264897642016The role of the Src Homology-2 domain containing protein B (SHB) in β cells.7
122001372002IL-2 receptor signaling through the Shb adapter protein in T and NK cells.6
166305612006SHB and angiogenic factors promote ES cell differentiation to insulin-producing cells.4
289823082017Tumor SHB gene expression affects disease characteristics in human acute myeloid leukemia.2
291944612017Evaluation and validation of commercial antibodies for the detection of Shb.1

Citation

Dessen P

SHB (SH2 domain containing adaptor protein B)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56141/shb