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SHB (SH2 domain containing adaptor protein B)

Identity

Alias_namesSHB adaptor protein (a Src homology 2 protein)
SHB (Src homology 2 domain containing) adaptor protein B
Src homology 2 domain containing adaptor protein B
Other aliasbA3J10.2
HGNC (Hugo) SHB
LocusID (NCBI) 6461
Atlas_Id 56141
Location 9p13.1  [Link to chromosome band 9p13]
Location_base_pair Starts at 37915898 and ends at 38069213 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRYBB2 (22q11.23) / SHB (9p13.2)HNRNPA2B1 (7p15.2) / SHB (9p13.2)SHB (9p13.2) / AKR1C8P (10p15.1)
SHB (9p13.2) / CDH23 (10q22.1)SHB (9p13.2) / DDX6 (11q23.3)SHB (9p13.2) / GRIN2A (16p13.2)
SHB (9p13.2) / KIAA1522 (1p35.1)SHB (9p13.2) / PALM2-AKAP2 (9q31.3)SHB (9p13.2) / SLC28A3 (9q21.32)
SHB (9p13.2) / VPS53 (17p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SHB   10838
Cards
Entrez_Gene (NCBI)SHB  6461  SH2 domain containing adaptor protein B
AliasesbA3J10.2
GeneCards (Weizmann)SHB
Ensembl hg19 (Hinxton)ENSG00000107338 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107338 [Gene_View]  chr9:37915898-38069213 [Contig_View]  SHB [Vega]
ICGC DataPortalENSG00000107338
TCGA cBioPortalSHB
AceView (NCBI)SHB
Genatlas (Paris)SHB
WikiGenes6461
SOURCE (Princeton)SHB
Genetics Home Reference (NIH)SHB
Genomic and cartography
GoldenPath hg38 (UCSC)SHB  -     chr9:37915898-38069213 -  9p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SHB  -     9p13.1   [Description]    (hg19-Feb_2009)
EnsemblSHB - 9p13.1 [CytoView hg19]  SHB - 9p13.1 [CytoView hg38]
Mapping of homologs : NCBISHB [Mapview hg19]  SHB [Mapview hg38]
OMIM600314   
Gene and transcription
Genbank (Entrez)AK055947 AK096227 BC029953 BC136581 BC136582
RefSeq transcript (Entrez)NM_003028
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SHB
Cluster EST : UnigeneHs.521482 [ NCBI ]
CGAP (NCI)Hs.521482
Alternative Splicing GalleryENSG00000107338
Gene ExpressionSHB [ NCBI-GEO ]   SHB [ EBI - ARRAY_EXPRESS ]   SHB [ SEEK ]   SHB [ MEM ]
Gene Expression Viewer (FireBrowse)SHB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6461
GTEX Portal (Tissue expression)SHB
Human Protein AtlasENSG00000107338-SHB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15464   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15464  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15464
Splice isoforms : SwissVarQ15464
PhosPhoSitePlusQ15464
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)SH2   
Domain families : Pfam (Sanger)SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00017   
Domain families : Smart (EMBL)SH2 (SM00252)  
Conserved Domain (NCBI)SHB
DMDM Disease mutations6461
Blocks (Seattle)SHB
SuperfamilyQ15464
Human Protein Atlas [tissue]ENSG00000107338-SHB [tissue]
Peptide AtlasQ15464
HPRD02635
IPIIPI00604688   IPI00017578   
Protein Interaction databases
DIP (DOE-UCLA)Q15464
IntAct (EBI)Q15464
FunCoupENSG00000107338
BioGRIDSHB
STRING (EMBL)SHB
ZODIACSHB
Ontologies - Pathways
QuickGOQ15464
Ontology : AmiGOP-body  angiogenesis  phosphotyrosine binding  SH3/SH2 adaptor activity  protein binding  nucleoplasm  cytosol  cytosol  plasma membrane  apoptotic process  signal transduction  positive regulation of signal transduction  cell differentiation  vascular endothelial growth factor receptor signaling pathway  
Ontology : EGO-EBIP-body  angiogenesis  phosphotyrosine binding  SH3/SH2 adaptor activity  protein binding  nucleoplasm  cytosol  cytosol  plasma membrane  apoptotic process  signal transduction  positive regulation of signal transduction  cell differentiation  vascular endothelial growth factor receptor signaling pathway  
NDEx NetworkSHB
Atlas of Cancer Signalling NetworkSHB
Wikipedia pathwaysSHB
Orthology - Evolution
OrthoDB6461
GeneTree (enSembl)ENSG00000107338
Phylogenetic Trees/Animal Genes : TreeFamSHB
HOVERGENQ15464
HOGENOMQ15464
Homologs : HomoloGeneSHB
Homology/Alignments : Family Browser (UCSC)SHB
Gene fusions - Rearrangements
Tumor Fusion PortalSHB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSHB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SHB
dbVarSHB
ClinVarSHB
1000_GenomesSHB 
Exome Variant ServerSHB
ExAC (Exome Aggregation Consortium)ENSG00000107338
GNOMAD BrowserENSG00000107338
Genetic variants : HAPMAP6461
Genomic Variants (DGV)SHB [DGVbeta]
DECIPHERSHB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSHB 
Mutations
ICGC Data PortalSHB 
TCGA Data PortalSHB 
Broad Tumor PortalSHB
OASIS PortalSHB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSHB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSHB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SHB
DgiDB (Drug Gene Interaction Database)SHB
DoCM (Curated mutations)SHB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SHB (select a term)
intoGenSHB
Cancer3DSHB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600314   
Orphanet
DisGeNETSHB
MedgenSHB
Genetic Testing Registry SHB
NextProtQ15464 [Medical]
TSGene6461
GENETestsSHB
Target ValidationSHB
Huge Navigator SHB [HugePedia]
snp3D : Map Gene to Disease6461
BioCentury BCIQSHB
ClinGenSHB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6461
Chemical/Pharm GKB GenePA35744
Clinical trialSHB
Miscellaneous
canSAR (ICR)SHB (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSHB
EVEXSHB
GoPubMedSHB
iHOPSHB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:34:31 CET 2017

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