Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SHC2 (SHC adaptor protein 2)

Identity

Alias_namesSHC (Src homology 2 domain containing) transforming protein 2
Alias_symbol (synonym)SLI
SCK
SHCB
Other alias
HGNC (Hugo) SHC2
LocusID (NCBI) 25759
Atlas_Id 42289
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 416583 and ends at 460996 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SHC2 (19p13.3) / CREB3L3 (19p13.3)SHC2 (19p13.3) / RNF126 (19p13.3)SHC2 (19p13.3) / TJP3 (19p13.3)
TYK2 (19p13.2) / SHC2 (19p13.3)SHC2 19p13.3 / CREB3L3 19p13.3SHC2 19p13.3 / RNF126 19p13.3
SHC2 19p13.3 / TJP3 19p13.3TYK2 19p13.2 / SHC2 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(19;19)(p13;p13) SHC2/TJP3
t(19;19)(p13;p13) TYK2/SHC2
t(19;19)(p13;p13) SHC2/CREB3L3
t(19;19)(p13;p13) SHC2/RNF126

External links

Nomenclature
HGNC (Hugo)SHC2   29869
Cards
Entrez_Gene (NCBI)SHC2  25759  SHC adaptor protein 2
AliasesSCK; SHCB; SLI
GeneCards (Weizmann)SHC2
Ensembl hg19 (Hinxton)ENSG00000129946 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129946 [Gene_View]  chr19:416583-460996 [Contig_View]  SHC2 [Vega]
ICGC DataPortalENSG00000129946
TCGA cBioPortalSHC2
AceView (NCBI)SHC2
Genatlas (Paris)SHC2
WikiGenes25759
SOURCE (Princeton)SHC2
Genetics Home Reference (NIH)SHC2
Genomic and cartography
GoldenPath hg38 (UCSC)SHC2  -     chr19:416583-460996 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SHC2  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblSHC2 - 19p13.3 [CytoView hg19]  SHC2 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBISHC2 [Mapview hg19]  SHC2 [Mapview hg38]
OMIM605217   
Gene and transcription
Genbank (Entrez)AB001451 AL134433 AL360254 BC030527 BC034544
RefSeq transcript (Entrez)NM_012435
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SHC2
Cluster EST : UnigeneHs.30965 [ NCBI ]
CGAP (NCI)Hs.30965
Alternative Splicing GalleryENSG00000129946
Gene ExpressionSHC2 [ NCBI-GEO ]   SHC2 [ EBI - ARRAY_EXPRESS ]   SHC2 [ SEEK ]   SHC2 [ MEM ]
Gene Expression Viewer (FireBrowse)SHC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25759
GTEX Portal (Tissue expression)SHC2
Human Protein AtlasENSG00000129946-SHC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP98077   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP98077  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP98077
Splice isoforms : SwissVarP98077
PhosPhoSitePlusP98077
Domaine pattern : Prosite (Expaxy)PID (PS01179)    SH2 (PS50001)   
Domains : Interpro (EBI)PH_dom-like    PID_Shc-like    PTB/PI_dom    SH2    SHC2   
Domain families : Pfam (Sanger)PID (PF00640)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00640    pfam00017   
Domain families : Smart (EMBL)PTB (SM00462)  SH2 (SM00252)  
Conserved Domain (NCBI)SHC2
DMDM Disease mutations25759
Blocks (Seattle)SHC2
SuperfamilyP98077
Human Protein Atlas [tissue]ENSG00000129946-SHC2 [tissue]
Peptide AtlasP98077
IPIIPI00786975   
Protein Interaction databases
DIP (DOE-UCLA)P98077
IntAct (EBI)P98077
FunCoupENSG00000129946
BioGRIDSHC2
STRING (EMBL)SHC2
ZODIACSHC2
Ontologies - Pathways
QuickGOP98077
Ontology : AmiGOMAPK cascade  activation of MAPK activity  Ras guanyl-nucleotide exchange factor activity  protein binding  cellular_component  cytosol  plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  Ras protein signal transduction  receptor tyrosine kinase binding  vascular endothelial growth factor receptor signaling pathway  
Ontology : EGO-EBIMAPK cascade  activation of MAPK activity  Ras guanyl-nucleotide exchange factor activity  protein binding  cellular_component  cytosol  plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  Ras protein signal transduction  receptor tyrosine kinase binding  vascular endothelial growth factor receptor signaling pathway  
Pathways : KEGGFocal adhesion    VEGF signaling pathway    Natural killer cell mediated cytotoxicity    Insulin signaling pathway   
NDEx NetworkSHC2
Atlas of Cancer Signalling NetworkSHC2
Wikipedia pathwaysSHC2
Orthology - Evolution
OrthoDB25759
GeneTree (enSembl)ENSG00000129946
Phylogenetic Trees/Animal Genes : TreeFamSHC2
HOVERGENP98077
HOGENOMP98077
Homologs : HomoloGeneSHC2
Homology/Alignments : Family Browser (UCSC)SHC2
Gene fusions - Rearrangements
Fusion : MitelmanSHC2/CREB3L3 [19p13.3/19p13.3]  
Fusion : MitelmanSHC2/RNF126 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion : MitelmanSHC2/TJP3 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion : MitelmanTYK2/SHC2 [19p13.2/19p13.3]  [t(19;19)(p13;p13)]  
Fusion: TCGA_MDACCSHC2 19p13.3 CREB3L3 19p13.3 LUAD
Fusion: TCGA_MDACCSHC2 19p13.3 RNF126 19p13.3 SKCM
Fusion: TCGA_MDACCSHC2 19p13.3 TJP3 19p13.3 LGG
Fusion: TCGA_MDACCTYK2 19p13.2 SHC2 19p13.3 BRCA
Fusion PortalSHC2 19p13.3 CREB3L3 19p13.3 LUAD
Fusion PortalSHC2 19p13.3 RNF126 19p13.3 SKCM
Fusion PortalSHC2 19p13.3 TJP3 19p13.3 LGG
Fusion PortalTYK2 19p13.2 SHC2 19p13.3 BRCA
Fusion : QuiverSHC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSHC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SHC2
dbVarSHC2
ClinVarSHC2
1000_GenomesSHC2 
Exome Variant ServerSHC2
ExAC (Exome Aggregation Consortium)ENSG00000129946
GNOMAD BrowserENSG00000129946
Genetic variants : HAPMAP25759
Genomic Variants (DGV)SHC2 [DGVbeta]
DECIPHERSHC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSHC2 
Mutations
ICGC Data PortalSHC2 
TCGA Data PortalSHC2 
Broad Tumor PortalSHC2
OASIS PortalSHC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSHC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSHC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SHC2
DgiDB (Drug Gene Interaction Database)SHC2
DoCM (Curated mutations)SHC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SHC2 (select a term)
intoGenSHC2
Cancer3DSHC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605217   
Orphanet
DisGeNETSHC2
MedgenSHC2
Genetic Testing Registry SHC2
NextProtP98077 [Medical]
TSGene25759
GENETestsSHC2
Target ValidationSHC2
Huge Navigator SHC2 [HugePedia]
snp3D : Map Gene to Disease25759
BioCentury BCIQSHC2
ClinGenSHC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25759
Chemical/Pharm GKB GenePA134971076
Clinical trialSHC2
Miscellaneous
canSAR (ICR)SHC2 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSHC2
EVEXSHC2
GoPubMedSHC2
iHOPSHC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:37:17 CET 2018
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