Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SHC2 (SHC adaptor protein 2)

Identity

Alias (NCBI)SCK
SHCB
SLI
HGNC (Hugo) SHC2
HGNC Alias symbSLI
SCK
SHCB
HGNC Alias nameneuronal Shc adaptor homolog
HGNC Previous nameSHC (Src homology 2 domain containing) transforming protein 2
LocusID (NCBI) 25759
Atlas_Id 42289
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 416583 and ends at 460996 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SHC2 (19p13.3)::CREB3L3 (19p13.3)SHC2 (19p13.3)::RNF126 (19p13.3)SHC2 (19p13.3)::TJP3 (19p13.3)
TYK2 (19p13.2)::SHC2 (19p13.3)SHC2 19p13.3::CREB3L3 19p13.3SHC2 19p13.3::RNF126 19p13.3
SHC2 19p13.3::TJP3 19p13.3TYK2 19p13.2::SHC2 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)SHC2   29869
Cards
Entrez_Gene (NCBI)SHC2    SHC adaptor protein 2
AliasesSCK; SHCB; SLI
GeneCards (Weizmann)SHC2
Ensembl hg19 (Hinxton)ENSG00000129946 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129946 [Gene_View]  ENSG00000129946 [Sequence]  chr19:416583-460996 [Contig_View]  SHC2 [Vega]
ICGC DataPortalENSG00000129946
TCGA cBioPortalSHC2
AceView (NCBI)SHC2
Genatlas (Paris)SHC2
SOURCE (Princeton)SHC2
Genetics Home Reference (NIH)SHC2
Genomic and cartography
GoldenPath hg38 (UCSC)SHC2  -     chr19:416583-460996 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SHC2  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathSHC2 - 19p13.3 [CytoView hg19]  SHC2 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000129946
Genome Data Viewer NCBISHC2 [Mapview hg19]  
OMIM605217   
Gene and transcription
Genbank (Entrez)AB001451 AL134433 AL360254 BC030527 BC034544
RefSeq transcript (Entrez)NM_001387056 NM_012435
Consensus coding sequences : CCDS (NCBI)SHC2
Gene ExpressionSHC2 [ NCBI-GEO ]   SHC2 [ EBI - ARRAY_EXPRESS ]   SHC2 [ SEEK ]   SHC2 [ MEM ]
Gene Expression Viewer (FireBrowse)SHC2 [ Firebrowse - Broad ]
GenevisibleExpression of SHC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25759
GTEX Portal (Tissue expression)SHC2
Human Protein AtlasENSG00000129946-SHC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP98077   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP98077  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP98077
PhosPhoSitePlusP98077
Domaine pattern : Prosite (Expaxy)PID (PS01179)    SH2 (PS50001)   
Domains : Interpro (EBI)PH-like_dom_sf    PID_Shc-like    PTB/PI_dom    SH2    SH2_dom_sf    SHC2    SHC_SH2   
Domain families : Pfam (Sanger)PID (PF00640)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00640    pfam00017   
Domain families : Smart (EMBL)PTB (SM00462)  SH2 (SM00252)  
Conserved Domain (NCBI)SHC2
SuperfamilyP98077
AlphaFold pdb e-kbP98077   
Human Protein Atlas [tissue]ENSG00000129946-SHC2 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)P98077
IntAct (EBI)P98077
BioGRIDSHC2
STRING (EMBL)SHC2
ZODIACSHC2
Ontologies - Pathways
QuickGOP98077
Ontology : AmiGOprotein binding  cellular_component  cytosol  plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  protein kinase binding  receptor tyrosine kinase binding  intracellular signal transduction  positive regulation of MAPK cascade  
Ontology : EGO-EBIprotein binding  cellular_component  cytosol  plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  protein kinase binding  receptor tyrosine kinase binding  intracellular signal transduction  positive regulation of MAPK cascade  
Pathways : KEGGKEGG_ERBB_SIGNALING    KEGG_CHEMOKINE_SIGNALING    KEGG_VEGF_SIGNALING    KEGG_FOCAL_ADHESION    KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY    KEGG_NEUROTROPHIN_SIGNALING    KEGG_INSULIN_SIGNALING    KEGG_GLIOMA    KEGG_CHRONIC_MYELOID_LEUKEMIA   
NDEx NetworkSHC2
Atlas of Cancer Signalling NetworkSHC2
Wikipedia pathwaysSHC2
Orthology - Evolution
OrthoDB25759
GeneTree (enSembl)ENSG00000129946
Phylogenetic Trees/Animal Genes : TreeFamSHC2
Homologs : HomoloGeneSHC2
Homology/Alignments : Family Browser (UCSC)SHC2
Gene fusions - Rearrangements
Fusion : MitelmanSHC2::CREB3L3 [19p13.3/19p13.3]  
Fusion : MitelmanSHC2::RNF126 [19p13.3/19p13.3]  
Fusion : MitelmanSHC2::TJP3 [19p13.3/19p13.3]  
Fusion : MitelmanTYK2::SHC2 [19p13.2/19p13.3]  
Fusion : QuiverSHC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSHC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SHC2
dbVarSHC2
ClinVarSHC2
MonarchSHC2
1000_GenomesSHC2 
Exome Variant ServerSHC2
GNOMAD BrowserENSG00000129946
Varsome BrowserSHC2
ACMGSHC2 variants
VarityP98077
Genomic Variants (DGV)SHC2 [DGVbeta]
DECIPHERSHC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSHC2 
Mutations
ICGC Data PortalSHC2 
TCGA Data PortalSHC2 
Broad Tumor PortalSHC2
OASIS PortalSHC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSHC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSHC2
Mutations and Diseases : HGMDSHC2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSHC2
DgiDB (Drug Gene Interaction Database)SHC2
DoCM (Curated mutations)SHC2
CIViC (Clinical Interpretations of Variants in Cancer)SHC2
Cancer3DSHC2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605217   
Orphanet
DisGeNETSHC2
MedgenSHC2
Genetic Testing Registry SHC2
NextProtP98077 [Medical]
GENETestsSHC2
Target ValidationSHC2
Huge Navigator SHC2 [HugePedia]
ClinGenSHC2
Clinical trials, drugs, therapy
MyCancerGenomeSHC2
Protein Interactions : CTDSHC2
Pharm GKB GenePA134971076
Pharm GKB PathwaysPA162356267   
PharosP98077
Clinical trialSHC2
Miscellaneous
canSAR (ICR)SHC2
HarmonizomeSHC2
ARCHS4SHC2
DataMed IndexSHC2
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSHC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:58:29 CET 2022
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