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SHC3 (SHC adaptor protein 3)

Identity

Alias (NCBI)N-Shc
NSHC
RAI
SHCC
HGNC (Hugo) SHC3
HGNC Alias symbN-Shc
NSHC
SHCC
HGNC Previous namesrc homology 2 domain containing transforming protein C3
 SHC (Src homology 2 domain containing) transforming protein 3
LocusID (NCBI) 53358
Atlas_Id 42290
Location 9q22.1  [Link to chromosome band 9q22]
Location_base_pair Starts at 89005771 and ends at 89178818 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ORC5 (7q22.1)::SHC3 (9q22.1)SHC3 (9q22.1)::KRT7 (12q13.13)UBQLN1 (9q21.32)::SHC3 (9q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SHC3   18181
Cards
Entrez_Gene (NCBI)SHC3    SHC adaptor protein 3
AliasesN-Shc; NSHC; RAI; SHCC
GeneCards (Weizmann)SHC3
Ensembl hg19 (Hinxton)ENSG00000148082 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148082 [Gene_View]  ENSG00000148082 [Sequence]  chr9:89005771-89178818 [Contig_View]  SHC3 [Vega]
ICGC DataPortalENSG00000148082
TCGA cBioPortalSHC3
AceView (NCBI)SHC3
Genatlas (Paris)SHC3
SOURCE (Princeton)SHC3
Genetics Home Reference (NIH)SHC3
Genomic and cartography
GoldenPath hg38 (UCSC)SHC3  -     chr9:89005771-89178818 -  9q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SHC3  -     9q22.1   [Description]    (hg19-Feb_2009)
GoldenPathSHC3 - 9q22.1 [CytoView hg19]  SHC3 - 9q22.1 [CytoView hg38]
ImmunoBaseENSG00000148082
Genome Data Viewer NCBISHC3 [Mapview hg19]  
OMIM605263   
Gene and transcription
Genbank (Entrez)AK127258 BC026314 BC042431 BX538228 BX641139
RefSeq transcript (Entrez)NM_016848
Consensus coding sequences : CCDS (NCBI)SHC3
Gene ExpressionSHC3 [ NCBI-GEO ]   SHC3 [ EBI - ARRAY_EXPRESS ]   SHC3 [ SEEK ]   SHC3 [ MEM ]
Gene Expression Viewer (FireBrowse)SHC3 [ Firebrowse - Broad ]
GenevisibleExpression of SHC3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53358
GTEX Portal (Tissue expression)SHC3
Human Protein AtlasENSG00000148082-SHC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92529   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92529  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92529
PhosPhoSitePlusQ92529
Domaine pattern : Prosite (Expaxy)PID (PS01179)    SH2 (PS50001)   
Domains : Interpro (EBI)PH-like_dom_sf    PID_Shc-like    PTB/PI_dom    SH2    SH2_dom_sf    Shc3/ShcC/N-Shc    SHC_SH2   
Domain families : Pfam (Sanger)PID (PF00640)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00640    pfam00017   
Domain families : Smart (EMBL)PTB (SM00462)  SH2 (SM00252)  
Conserved Domain (NCBI)SHC3
SuperfamilyQ92529
AlphaFold pdb e-kbQ92529   
Human Protein Atlas [tissue]ENSG00000148082-SHC3 [tissue]
HPRD12005
Protein Interaction databases
DIP (DOE-UCLA)Q92529
IntAct (EBI)Q92529
BioGRIDSHC3
STRING (EMBL)SHC3
ZODIACSHC3
Ontologies - Pathways
QuickGOQ92529
Ontology : AmiGOphosphotyrosine residue binding  protein binding  cellular_component  cytosol  plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  epidermal growth factor receptor signaling pathway  central nervous system development  protein kinase binding  receptor tyrosine kinase binding  intracellular signal transduction  
Ontology : EGO-EBIphosphotyrosine residue binding  protein binding  cellular_component  cytosol  plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  epidermal growth factor receptor signaling pathway  central nervous system development  protein kinase binding  receptor tyrosine kinase binding  intracellular signal transduction  
Pathways : KEGGKEGG_ERBB_SIGNALING    KEGG_CHEMOKINE_SIGNALING    KEGG_FOCAL_ADHESION    KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY    KEGG_NEUROTROPHIN_SIGNALING    KEGG_INSULIN_SIGNALING    KEGG_GLIOMA    KEGG_CHRONIC_MYELOID_LEUKEMIA   
NDEx NetworkSHC3
Atlas of Cancer Signalling NetworkSHC3
Wikipedia pathwaysSHC3
Orthology - Evolution
OrthoDB53358
GeneTree (enSembl)ENSG00000148082
Phylogenetic Trees/Animal Genes : TreeFamSHC3
Homologs : HomoloGeneSHC3
Homology/Alignments : Family Browser (UCSC)SHC3
Gene fusions - Rearrangements
Fusion : QuiverSHC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSHC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SHC3
dbVarSHC3
ClinVarSHC3
MonarchSHC3
1000_GenomesSHC3 
Exome Variant ServerSHC3
GNOMAD BrowserENSG00000148082
Varsome BrowserSHC3
ACMGSHC3 variants
VarityQ92529
Genomic Variants (DGV)SHC3 [DGVbeta]
DECIPHERSHC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSHC3 
Mutations
ICGC Data PortalSHC3 
TCGA Data PortalSHC3 
Broad Tumor PortalSHC3
OASIS PortalSHC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSHC3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSHC3
Mutations and Diseases : HGMDSHC3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSHC3
DgiDB (Drug Gene Interaction Database)SHC3
DoCM (Curated mutations)SHC3
CIViC (Clinical Interpretations of Variants in Cancer)SHC3
Cancer3DSHC3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605263   
Orphanet
DisGeNETSHC3
MedgenSHC3
Genetic Testing Registry SHC3
NextProtQ92529 [Medical]
GENETestsSHC3
Target ValidationSHC3
Huge Navigator SHC3 [HugePedia]
ClinGenSHC3
Clinical trials, drugs, therapy
MyCancerGenomeSHC3
Protein Interactions : CTDSHC3
Pharm GKB GenePA134913435
Pharm GKB PathwaysPA162356267   
PharosQ92529
Clinical trialSHC3
Miscellaneous
canSAR (ICR)SHC3
HarmonizomeSHC3
ARCHS4SHC3
DataMed IndexSHC3
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSHC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:58:29 CET 2022

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