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SHC3 (SHC adaptor protein 3)

Identity

Alias_namessrc homology 2 domain containing transforming protein C3
SHC (Src homology 2 domain containing) transforming protein 3
Alias_symbol (synonym)N-Shc
NSHC
SHCC
Other aliasRAI
HGNC (Hugo) SHC3
LocusID (NCBI) 53358
Atlas_Id 42290
Location 9q22.1  [Link to chromosome band 9q22]
Location_base_pair Starts at 89005771 and ends at 89178767 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ORC5 (7q22.1) / SHC3 (9q22.1)SHC3 (9q22.1) / KRT7 (12q13.13)UBQLN1 (9q21.32) / SHC3 (9q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SHC3   18181
Cards
Entrez_Gene (NCBI)SHC3  53358  SHC adaptor protein 3
AliasesN-Shc; NSHC; RAI; SHCC
GeneCards (Weizmann)SHC3
Ensembl hg19 (Hinxton)ENSG00000148082 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148082 [Gene_View]  chr9:89005771-89178767 [Contig_View]  SHC3 [Vega]
ICGC DataPortalENSG00000148082
TCGA cBioPortalSHC3
AceView (NCBI)SHC3
Genatlas (Paris)SHC3
WikiGenes53358
SOURCE (Princeton)SHC3
Genetics Home Reference (NIH)SHC3
Genomic and cartography
GoldenPath hg38 (UCSC)SHC3  -     chr9:89005771-89178767 -  9q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SHC3  -     9q22.1   [Description]    (hg19-Feb_2009)
EnsemblSHC3 - 9q22.1 [CytoView hg19]  SHC3 - 9q22.1 [CytoView hg38]
Mapping of homologs : NCBISHC3 [Mapview hg19]  SHC3 [Mapview hg38]
OMIM605263   
Gene and transcription
Genbank (Entrez)AK127258 BC026314 BC042431 BX538228 BX641139
RefSeq transcript (Entrez)NM_016848
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SHC3
Cluster EST : UnigeneHs.292737 [ NCBI ]
CGAP (NCI)Hs.292737
Alternative Splicing GalleryENSG00000148082
Gene ExpressionSHC3 [ NCBI-GEO ]   SHC3 [ EBI - ARRAY_EXPRESS ]   SHC3 [ SEEK ]   SHC3 [ MEM ]
Gene Expression Viewer (FireBrowse)SHC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53358
GTEX Portal (Tissue expression)SHC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92529   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92529  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92529
Splice isoforms : SwissVarQ92529
PhosPhoSitePlusQ92529
Domaine pattern : Prosite (Expaxy)PID (PS01179)    SH2 (PS50001)   
Domains : Interpro (EBI)PH_dom-like    PID_Shc-like    PTB/PI_dom    SH2    Shc3/ShcC/N-Shc   
Domain families : Pfam (Sanger)PID (PF00640)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00640    pfam00017   
Domain families : Smart (EMBL)PTB (SM00462)  SH2 (SM00252)  
Conserved Domain (NCBI)SHC3
DMDM Disease mutations53358
Blocks (Seattle)SHC3
SuperfamilyQ92529
Human Protein AtlasENSG00000148082
Peptide AtlasQ92529
HPRD12005
IPIIPI00409679   IPI00410340   IPI00644234   
Protein Interaction databases
DIP (DOE-UCLA)Q92529
IntAct (EBI)Q92529
FunCoupENSG00000148082
BioGRIDSHC3
STRING (EMBL)SHC3
ZODIACSHC3
Ontologies - Pathways
QuickGOQ92529
Ontology : AmiGOMAPK cascade  phosphotyrosine binding  signal transducer activity  Ras guanyl-nucleotide exchange factor activity  protein binding  cellular_component  cytosol  plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  epidermal growth factor receptor signaling pathway  Ras protein signal transduction  axon guidance  central nervous system development  learning or memory  receptor tyrosine kinase binding  synaptic transmission, glutamatergic  positive regulation of GTPase activity  
Ontology : EGO-EBIMAPK cascade  phosphotyrosine binding  signal transducer activity  Ras guanyl-nucleotide exchange factor activity  protein binding  cellular_component  cytosol  plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  epidermal growth factor receptor signaling pathway  Ras protein signal transduction  axon guidance  central nervous system development  learning or memory  receptor tyrosine kinase binding  synaptic transmission, glutamatergic  positive regulation of GTPase activity  
Pathways : KEGG   
NDEx NetworkSHC3
Atlas of Cancer Signalling NetworkSHC3
Wikipedia pathwaysSHC3
Orthology - Evolution
OrthoDB53358
GeneTree (enSembl)ENSG00000148082
Phylogenetic Trees/Animal Genes : TreeFamSHC3
HOVERGENQ92529
HOGENOMQ92529
Homologs : HomoloGeneSHC3
Homology/Alignments : Family Browser (UCSC)SHC3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSHC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SHC3
dbVarSHC3
ClinVarSHC3
1000_GenomesSHC3 
Exome Variant ServerSHC3
ExAC (Exome Aggregation Consortium)SHC3 (select the gene name)
Genetic variants : HAPMAP53358
Genomic Variants (DGV)SHC3 [DGVbeta]
DECIPHERSHC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSHC3 
Mutations
ICGC Data PortalSHC3 
TCGA Data PortalSHC3 
Broad Tumor PortalSHC3
OASIS PortalSHC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSHC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSHC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SHC3
DgiDB (Drug Gene Interaction Database)SHC3
DoCM (Curated mutations)SHC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SHC3 (select a term)
intoGenSHC3
Cancer3DSHC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605263   
Orphanet
MedgenSHC3
Genetic Testing Registry SHC3
NextProtQ92529 [Medical]
TSGene53358
GENETestsSHC3
Target ValidationSHC3
Huge Navigator SHC3 [HugePedia]
snp3D : Map Gene to Disease53358
BioCentury BCIQSHC3
ClinGenSHC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD53358
Chemical/Pharm GKB GenePA134913435
Clinical trialSHC3
Miscellaneous
canSAR (ICR)SHC3 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSHC3
EVEXSHC3
GoPubMedSHC3
iHOPSHC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:55:25 CEST 2017

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