Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SHCBP1 (SHC binding and spindle associated 1)

Identity

Alias_namesSHC SH2-domain binding protein 1
Alias_symbol (synonym)FLJ22009
PAL
Other alias
HGNC (Hugo) SHCBP1
LocusID (NCBI) 79801
Atlas_Id 56561
Location 16q11.2  [Link to chromosome band 16q11]
Location_base_pair Starts at 46580556 and ends at 46621399 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NRIP1 (21q11.2) / SHCBP1 (16q11.2)SHCBP1 (16q11.2) / JCHAIN (4q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(16;21)(q11;q21) NRIP1/SHCBP1

External links

Nomenclature
HGNC (Hugo)SHCBP1   29547
Cards
Entrez_Gene (NCBI)SHCBP1  79801  SHC binding and spindle associated 1
AliasesPAL
GeneCards (Weizmann)SHCBP1
Ensembl hg19 (Hinxton)ENSG00000171241 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171241 [Gene_View]  ENSG00000171241 [Sequence]  chr16:46580556-46621399 [Contig_View]  SHCBP1 [Vega]
ICGC DataPortalENSG00000171241
TCGA cBioPortalSHCBP1
AceView (NCBI)SHCBP1
Genatlas (Paris)SHCBP1
WikiGenes79801
SOURCE (Princeton)SHCBP1
Genetics Home Reference (NIH)SHCBP1
Genomic and cartography
GoldenPath hg38 (UCSC)SHCBP1  -     chr16:46580556-46621399 -  16q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SHCBP1  -     16q11.2   [Description]    (hg19-Feb_2009)
GoldenPathSHCBP1 - 16q11.2 [CytoView hg19]  SHCBP1 - 16q11.2 [CytoView hg38]
ImmunoBaseENSG00000171241
Mapping of homologs : NCBISHCBP1 [Mapview hg19]  SHCBP1 [Mapview hg38]
OMIM611027   
Gene and transcription
Genbank (Entrez)AA401234 AK025662 AK055931 AK225315 AK292164
RefSeq transcript (Entrez)NM_001324318 NM_001324319 NM_024745
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SHCBP1
Cluster EST : UnigeneHs.123253 [ NCBI ]
CGAP (NCI)Hs.123253
Alternative Splicing GalleryENSG00000171241
Gene ExpressionSHCBP1 [ NCBI-GEO ]   SHCBP1 [ EBI - ARRAY_EXPRESS ]   SHCBP1 [ SEEK ]   SHCBP1 [ MEM ]
Gene Expression Viewer (FireBrowse)SHCBP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79801
GTEX Portal (Tissue expression)SHCBP1
Human Protein AtlasENSG00000171241-SHCBP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NEM2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NEM2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NEM2
Splice isoforms : SwissVarQ8NEM2
PhosPhoSitePlusQ8NEM2
Domains : Interpro (EBI)PbH1    Pectin_lyas_fold    Pectin_lyase_fold/virulence   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)PbH1 (SM00710)  
Conserved Domain (NCBI)SHCBP1
DMDM Disease mutations79801
Blocks (Seattle)SHCBP1
SuperfamilyQ8NEM2
Human Protein Atlas [tissue]ENSG00000171241-SHCBP1 [tissue]
Peptide AtlasQ8NEM2
HPRD11557
IPIIPI00168691   
Protein Interaction databases
DIP (DOE-UCLA)Q8NEM2
IntAct (EBI)Q8NEM2
FunCoupENSG00000171241
BioGRIDSHCBP1
STRING (EMBL)SHCBP1
ZODIACSHCBP1
Ontologies - Pathways
QuickGOQ8NEM2
Ontology : AmiGOprotein binding  cytoplasm  spindle  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  midbody  SH2 domain binding  regulation of neural precursor cell proliferation  
Ontology : EGO-EBIprotein binding  cytoplasm  spindle  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  midbody  SH2 domain binding  regulation of neural precursor cell proliferation  
NDEx NetworkSHCBP1
Atlas of Cancer Signalling NetworkSHCBP1
Wikipedia pathwaysSHCBP1
Orthology - Evolution
OrthoDB79801
GeneTree (enSembl)ENSG00000171241
Phylogenetic Trees/Animal Genes : TreeFamSHCBP1
HOGENOMQ8NEM2
Homologs : HomoloGeneSHCBP1
Homology/Alignments : Family Browser (UCSC)SHCBP1
Gene fusions - Rearrangements
Fusion : QuiverSHCBP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSHCBP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SHCBP1
dbVarSHCBP1
ClinVarSHCBP1
1000_GenomesSHCBP1 
Exome Variant ServerSHCBP1
ExAC (Exome Aggregation Consortium)ENSG00000171241
GNOMAD BrowserENSG00000171241
Varsome BrowserSHCBP1
Genetic variants : HAPMAP79801
Genomic Variants (DGV)SHCBP1 [DGVbeta]
DECIPHERSHCBP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSHCBP1 
Mutations
ICGC Data PortalSHCBP1 
TCGA Data PortalSHCBP1 
Broad Tumor PortalSHCBP1
OASIS PortalSHCBP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSHCBP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSHCBP1
Mutations and Diseases : HGMDSHCBP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SHCBP1
DgiDB (Drug Gene Interaction Database)SHCBP1
DoCM (Curated mutations)SHCBP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SHCBP1 (select a term)
intoGenSHCBP1
Cancer3DSHCBP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611027   
Orphanet
DisGeNETSHCBP1
MedgenSHCBP1
Genetic Testing Registry SHCBP1
NextProtQ8NEM2 [Medical]
TSGene79801
GENETestsSHCBP1
Target ValidationSHCBP1
Huge Navigator SHCBP1 [HugePedia]
snp3D : Map Gene to Disease79801
BioCentury BCIQSHCBP1
ClinGenSHCBP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79801
Chemical/Pharm GKB GenePA134931125
Clinical trialSHCBP1
Miscellaneous
canSAR (ICR)SHCBP1 (select the gene name)
DataMed IndexSHCBP1
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSHCBP1
EVEXSHCBP1
GoPubMedSHCBP1
iHOPSHCBP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:07:19 CET 2019
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