SHKBP1 (SH3KBP1 binding protein 1)

2012-02-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
PP203,Sb1

Other Information

Locus ID:

NCBI: 92799
MIM: 617322
HGNC: 19214
Ensembl: ENSG00000160410

Variants:

dbSNP: 92799
ClinVar: 92799
TCGA: ENSG00000160410
COSMIC: SHKBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160410ENST00000291842Q8TBC3
ENSG00000160410ENST00000593764M0R0E3
ENSG00000160410ENST00000594298M0R0K4
ENSG00000160410ENST00000594862M0R1G0
ENSG00000160410ENST00000595523M0QX42
ENSG00000160410ENST00000595631M0QXA4
ENSG00000160410ENST00000595726M0QZE8
ENSG00000160410ENST00000595803M0QZF2
ENSG00000160410ENST00000595945M0QYJ9
ENSG00000160410ENST00000596163M0R204
ENSG00000160410ENST00000597396M0R0S2
ENSG00000160410ENST00000599575M0R2U6
ENSG00000160410ENST00000600320M0QYB1
ENSG00000160410ENST00000600718M0R0S1
ENSG00000160410ENST00000600733M0R2P6
ENSG00000160410ENST00000602011M0QZF4

Expression (GTEx)

0
50
100
150
200
250
300
350

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
218302252011SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex.8
167338012006Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells.3
254573852015Genetic variant in the BCL11A (rs1427407), but not HBS1-MYB (rs6934903) loci associate with fetal hemoglobin levels in Indian sickle cell disease patients.3
311383182019The TGFβ-miR-499a-SHKBP1 pathway induces resistance to EGFR inhibitors in osteosarcoma cancer stem cell-like cells.2

Citation

Dessen P

SHKBP1 (SH3KBP1 binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52592/shkbp1