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SHLD2 (shieldin complex subunit 2)

Identity

Alias (NCBI)FAM35A
FAM35A1
RINN2
bA163M19.1
HGNC (Hugo) SHLD2
HGNC Alias symbMGC5560
bA163M19.1
FAM35A1
RINN2
HGNC Previous nameFAM35A
HGNC Previous namefamily with sequence similarity 35, member A
 family with sequence similarity 35 member A
LocusID (NCBI) 54537
Atlas_Id 57453
Location 10q23.2  [Link to chromosome band 10q23]
Location_base_pair Starts at 87095206 and ends at 87191465 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)SHLD2   28773
Cards
Entrez_Gene (NCBI)SHLD2    shieldin complex subunit 2
AliasesFAM35A; FAM35A1; RINN2; bA163M19.1
GeneCards (Weizmann)SHLD2
Ensembl hg19 (Hinxton)ENSG00000122376 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122376 [Gene_View]  ENSG00000122376 [Sequence]  chr10:87095206-87191465 [Contig_View]  SHLD2 [Vega]
ICGC DataPortalENSG00000122376
TCGA cBioPortalSHLD2
AceView (NCBI)SHLD2
Genatlas (Paris)SHLD2
SOURCE (Princeton)SHLD2
Genetics Home Reference (NIH)SHLD2
Genomic and cartography
GoldenPath hg38 (UCSC)SHLD2  -     chr10:87095206-87191465 +  10q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SHLD2  -     10q23.2   [Description]    (hg19-Feb_2009)
GoldenPathSHLD2 - 10q23.2 [CytoView hg19]  SHLD2 - 10q23.2 [CytoView hg38]
ImmunoBaseENSG00000122376
Genome Data Viewer NCBISHLD2 [Mapview hg19]  
OMIM618029   
Gene and transcription
Genbank (Entrez)AF131775 AK022978 AK025471 AK025606 BC051863
RefSeq transcript (Entrez)NM_001330112 NM_001377158 NM_001377159 NM_001377160 NM_001377161 NM_001377162 NM_001377163 NM_001377164 NM_001377165 NM_001377166 NM_001377167 NM_001377168 NM_001377169 NM_001377170 NM_001377171 NM_001377172 NM_019054
Consensus coding sequences : CCDS (NCBI)SHLD2
Gene ExpressionSHLD2 [ NCBI-GEO ]   SHLD2 [ EBI - ARRAY_EXPRESS ]   SHLD2 [ SEEK ]   SHLD2 [ MEM ]
Gene Expression Viewer (FireBrowse)SHLD2 [ Firebrowse - Broad ]
GenevisibleExpression of SHLD2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54537
GTEX Portal (Tissue expression)SHLD2
Human Protein AtlasENSG00000122376-SHLD2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86V20   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86V20  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86V20
PhosPhoSitePlusQ86V20
Domains : Interpro (EBI)FAM35A    FAM35A_C   
Domain families : Pfam (Sanger)FAM35_C (PF15793)   
Domain families : Pfam (NCBI)pfam15793   
Conserved Domain (NCBI)SHLD2
PDB (RSDB)6KTO   
PDB Europe6KTO   
PDB (PDBSum)6KTO   
PDB (IMB)6KTO   
Structural Biology KnowledgeBase6KTO   
SCOP (Structural Classification of Proteins)6KTO   
CATH (Classification of proteins structures)6KTO   
SuperfamilyQ86V20
AlphaFold pdb e-kbQ86V20   
Human Protein Atlas [tissue]ENSG00000122376-SHLD2 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q86V20
IntAct (EBI)Q86V20
BioGRIDSHLD2
STRING (EMBL)SHLD2
ZODIACSHLD2
Ontologies - Pathways
QuickGOQ86V20
Ontology : AmiGOprotein binding  nucleus  nucleus  chromosome  DNA repair  regulation of double-strand break repair via homologous recombination  site of double-strand break  site of double-strand break  positive regulation of isotype switching  negative regulation of double-strand break repair via homologous recombination  positive regulation of double-strand break repair via nonhomologous end joining  
Ontology : EGO-EBIprotein binding  nucleus  nucleus  chromosome  DNA repair  regulation of double-strand break repair via homologous recombination  site of double-strand break  site of double-strand break  positive regulation of isotype switching  negative regulation of double-strand break repair via homologous recombination  positive regulation of double-strand break repair via nonhomologous end joining  
NDEx NetworkSHLD2
Atlas of Cancer Signalling NetworkSHLD2
Wikipedia pathwaysSHLD2
Orthology - Evolution
OrthoDB54537
GeneTree (enSembl)ENSG00000122376
Phylogenetic Trees/Animal Genes : TreeFamSHLD2
Homologs : HomoloGeneSHLD2
Homology/Alignments : Family Browser (UCSC)SHLD2
Gene fusions - Rearrangements
Fusion : QuiverSHLD2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSHLD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SHLD2
dbVarSHLD2
ClinVarSHLD2
MonarchSHLD2
1000_GenomesSHLD2 
Exome Variant ServerSHLD2
GNOMAD BrowserENSG00000122376
Varsome BrowserSHLD2
ACMGSHLD2 variants
VarityQ86V20
Genomic Variants (DGV)SHLD2 [DGVbeta]
DECIPHERSHLD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSHLD2 
Mutations
ICGC Data PortalSHLD2 
TCGA Data PortalSHLD2 
Broad Tumor PortalSHLD2
OASIS PortalSHLD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSHLD2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSHLD2
Mutations and Diseases : HGMDSHLD2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSHLD2
DgiDB (Drug Gene Interaction Database)SHLD2
DoCM (Curated mutations)SHLD2
CIViC (Clinical Interpretations of Variants in Cancer)SHLD2
Cancer3DSHLD2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618029   
Orphanet
DisGeNETSHLD2
MedgenSHLD2
Genetic Testing Registry SHLD2
NextProtQ86V20 [Medical]
GENETestsSHLD2
Target ValidationSHLD2
Huge Navigator SHLD2 [HugePedia]
ClinGenSHLD2
Clinical trials, drugs, therapy
MyCancerGenomeSHLD2
Protein Interactions : CTDSHLD2
Pharm GKB GenePA134926879
PharosQ86V20
Clinical trialSHLD2
Miscellaneous
canSAR (ICR)SHLD2
HarmonizomeSHLD2
DataMed IndexSHLD2
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSHLD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:31:06 CEST 2021

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