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SHLD3 (shieldin complex subunit 3)

Identity

Alias (NCBI)CTC-534A2.2
RINN1
HGNC (Hugo) SHLD3
HGNC Alias symbAC008560.1
FLJ26957
CTC-534A2.2
RINN1
LocusID (NCBI) 112441434
Atlas_Id 57724
Location 5q12.3  [Link to chromosome band 5q12]
Location_base_pair Starts at 65625027 and ends at 65630928 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)SHLD3   53826
Cards
Entrez_Gene (NCBI)SHLD3    shieldin complex subunit 3
AliasesCTC-534A2.2; RINN1
GeneCards (Weizmann)SHLD3
Ensembl hg19 (Hinxton)ENSG00000253251 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000253251 [Gene_View]  ENSG00000253251 [Sequence]  chr5:65625027-65630928 [Contig_View]  SHLD3 [Vega]
ICGC DataPortalENSG00000253251
TCGA cBioPortalSHLD3
AceView (NCBI)SHLD3
Genatlas (Paris)SHLD3
SOURCE (Princeton)SHLD3
Genetics Home Reference (NIH)SHLD3
Genomic and cartography
GoldenPath hg38 (UCSC)SHLD3  -     chr5:65625027-65630928 +  5q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SHLD3  -     5q12.3   [Description]    (hg19-Feb_2009)
GoldenPathSHLD3 - 5q12.3 [CytoView hg19]  SHLD3 - 5q12.3 [CytoView hg38]
ImmunoBaseENSG00000253251
Genome Data Viewer NCBISHLD3 [Mapview hg19]  
OMIM618030   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_001365341
Consensus coding sequences : CCDS (NCBI)SHLD3
Gene ExpressionSHLD3 [ NCBI-GEO ]   SHLD3 [ EBI - ARRAY_EXPRESS ]   SHLD3 [ SEEK ]   SHLD3 [ MEM ]
Gene Expression Viewer (FireBrowse)SHLD3 [ Firebrowse - Broad ]
GenevisibleExpression of SHLD3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)112441434
GTEX Portal (Tissue expression)SHLD3
Human Protein AtlasENSG00000253251-SHLD3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZNX1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZNX1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZNX1
PhosPhoSitePlusQ6ZNX1
Domains : Interpro (EBI)Shieldin_RINN1   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)SHLD3
PDB (RSDB)6K07    6K08    6KTO   
PDB Europe6K07    6K08    6KTO   
PDB (PDBSum)6K07    6K08    6KTO   
PDB (IMB)6K07    6K08    6KTO   
Structural Biology KnowledgeBase6K07    6K08    6KTO   
SCOP (Structural Classification of Proteins)6K07    6K08    6KTO   
CATH (Classification of proteins structures)6K07    6K08    6KTO   
SuperfamilyQ6ZNX1
AlphaFold pdb e-kbQ6ZNX1   
Human Protein Atlas [tissue]ENSG00000253251-SHLD3 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q6ZNX1
IntAct (EBI)Q6ZNX1
BioGRIDSHLD3
STRING (EMBL)SHLD3
ZODIACSHLD3
Ontologies - Pathways
QuickGOQ6ZNX1
Ontology : AmiGOprotein binding  chromosome  DNA repair  site of double-strand break  positive regulation of isotype switching  positive regulation of isotype switching  negative regulation of double-strand break repair via homologous recombination  negative regulation of double-strand break repair via homologous recombination  positive regulation of double-strand break repair via nonhomologous end joining  positive regulation of double-strand break repair via nonhomologous end joining  
Ontology : EGO-EBIprotein binding  chromosome  DNA repair  site of double-strand break  positive regulation of isotype switching  positive regulation of isotype switching  negative regulation of double-strand break repair via homologous recombination  negative regulation of double-strand break repair via homologous recombination  positive regulation of double-strand break repair via nonhomologous end joining  positive regulation of double-strand break repair via nonhomologous end joining  
NDEx NetworkSHLD3
Atlas of Cancer Signalling NetworkSHLD3
Wikipedia pathwaysSHLD3
Orthology - Evolution
OrthoDB112441434
GeneTree (enSembl)ENSG00000253251
Phylogenetic Trees/Animal Genes : TreeFamSHLD3
Homologs : HomoloGeneSHLD3
Homology/Alignments : Family Browser (UCSC)SHLD3
Gene fusions - Rearrangements
Fusion : QuiverSHLD3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSHLD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SHLD3
dbVarSHLD3
ClinVarSHLD3
MonarchSHLD3
1000_GenomesSHLD3 
Exome Variant ServerSHLD3
GNOMAD BrowserENSG00000253251
Varsome BrowserSHLD3
ACMGSHLD3 variants
VarityQ6ZNX1
Genomic Variants (DGV)SHLD3 [DGVbeta]
DECIPHERSHLD3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSHLD3 
Mutations
ICGC Data PortalSHLD3 
TCGA Data PortalSHLD3 
Broad Tumor PortalSHLD3
OASIS PortalSHLD3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSHLD3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSHLD3
Mutations and Diseases : HGMDSHLD3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSHLD3
DgiDB (Drug Gene Interaction Database)SHLD3
DoCM (Curated mutations)SHLD3
CIViC (Clinical Interpretations of Variants in Cancer)SHLD3
Cancer3DSHLD3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618030   
Orphanet
DisGeNETSHLD3
MedgenSHLD3
Genetic Testing Registry SHLD3
NextProtQ6ZNX1 [Medical]
GENETestsSHLD3
Target ValidationSHLD3
Huge Navigator SHLD3 [HugePedia]
ClinGenSHLD3
Clinical trials, drugs, therapy
MyCancerGenomeSHLD3
Protein Interactions : CTDSHLD3
Pharm GKB GenePA166181636
PharosQ6ZNX1
Clinical trialSHLD3
Miscellaneous
canSAR (ICR)SHLD3
HarmonizomeSHLD3
DataMed IndexSHLD3
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSHLD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:31:06 CEST 2021

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