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SHOC2 (SHOC2, leucine rich repeat scaffold protein)

Identity

Alias_namessoc-2 (suppressor of clear, C.elegans) homolog
soc-2 suppressor of clear homolog (C. elegans)
SHOC2 leucine-rich repeat scaffold protein
Alias_symbol (synonym)KIAA0862
SOC2
SUR-8
SOC-2
SUR8
Other aliasSIAA0862
HGNC (Hugo) SHOC2
LocusID (NCBI) 8036
Atlas_Id 51395
Location 10q25.2  [Link to chromosome band 10q25]
Location_base_pair Starts at 110919543 and ends at 111013667 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EGLN2 (19q13.2) / SHOC2 (10q25.2)NT5C2 (10q24.32) / SHOC2 (10q25.2)PTPN3 (9q31.3) / SHOC2 (10q25.2)
SHOC2 (10q25.2) / RBM20 (10q25.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)SHOC2   15454
LRG (Locus Reference Genomic)LRG_753
Cards
Entrez_Gene (NCBI)SHOC2  8036  SHOC2, leucine rich repeat scaffold protein
AliasesSIAA0862; SOC2; SUR8
GeneCards (Weizmann)SHOC2
Ensembl hg19 (Hinxton)ENSG00000108061 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108061 [Gene_View]  chr10:110919543-111013667 [Contig_View]  SHOC2 [Vega]
ICGC DataPortalENSG00000108061
TCGA cBioPortalSHOC2
AceView (NCBI)SHOC2
Genatlas (Paris)SHOC2
WikiGenes8036
SOURCE (Princeton)SHOC2
Genetics Home Reference (NIH)SHOC2
Genomic and cartography
GoldenPath hg38 (UCSC)SHOC2  -     chr10:110919543-111013667 +  10q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SHOC2  -     10q25.2   [Description]    (hg19-Feb_2009)
EnsemblSHOC2 - 10q25.2 [CytoView hg19]  SHOC2 - 10q25.2 [CytoView hg38]
Mapping of homologs : NCBISHOC2 [Mapview hg19]  SHOC2 [Mapview hg38]
OMIM602775   607721   
Gene and transcription
Genbank (Entrez)AB020669 AF054828 AF068920 AI202318 AK090820
RefSeq transcript (Entrez)NM_001269039 NM_001324336 NM_001324337 NM_007373
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SHOC2
Cluster EST : UnigeneHs.104315 [ NCBI ]
CGAP (NCI)Hs.104315
Alternative Splicing GalleryENSG00000108061
Gene ExpressionSHOC2 [ NCBI-GEO ]   SHOC2 [ EBI - ARRAY_EXPRESS ]   SHOC2 [ SEEK ]   SHOC2 [ MEM ]
Gene Expression Viewer (FireBrowse)SHOC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8036
GTEX Portal (Tissue expression)SHOC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UQ13   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UQ13  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UQ13
Splice isoforms : SwissVarQ9UQ13
PhosPhoSitePlusQ9UQ13
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp   
Domain families : Pfam (Sanger)LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam13855   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  
Conserved Domain (NCBI)SHOC2
DMDM Disease mutations8036
Blocks (Seattle)SHOC2
SuperfamilyQ9UQ13
Human Protein AtlasENSG00000108061
Peptide AtlasQ9UQ13
HPRD04144
IPIIPI00298928   IPI00479890   
Protein Interaction databases
DIP (DOE-UCLA)Q9UQ13
IntAct (EBI)Q9UQ13
FunCoupENSG00000108061
BioGRIDSHOC2
STRING (EMBL)SHOC2
ZODIACSHOC2
Ontologies - Pathways
QuickGOQ9UQ13
Ontology : AmiGOprotein phosphatase type 1 complex  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  Ras protein signal transduction  protein phosphatase 1 binding  fibroblast growth factor receptor signaling pathway  protein phosphatase regulator activity  protein phosphatase binding  positive regulation of Ras protein signal transduction  regulation of catalytic activity  
Ontology : EGO-EBIprotein phosphatase type 1 complex  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  Ras protein signal transduction  protein phosphatase 1 binding  fibroblast growth factor receptor signaling pathway  protein phosphatase regulator activity  protein phosphatase binding  positive regulation of Ras protein signal transduction  regulation of catalytic activity  
NDEx NetworkSHOC2
Atlas of Cancer Signalling NetworkSHOC2
Wikipedia pathwaysSHOC2
Orthology - Evolution
OrthoDB8036
GeneTree (enSembl)ENSG00000108061
Phylogenetic Trees/Animal Genes : TreeFamSHOC2
HOVERGENQ9UQ13
HOGENOMQ9UQ13
Homologs : HomoloGeneSHOC2
Homology/Alignments : Family Browser (UCSC)SHOC2
Gene fusions - Rearrangements
Fusion : MitelmanSHOC2/RBM20 [10q25.2/10q25.2]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSHOC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SHOC2
dbVarSHOC2
ClinVarSHOC2
1000_GenomesSHOC2 
Exome Variant ServerSHOC2
ExAC (Exome Aggregation Consortium)SHOC2 (select the gene name)
Genetic variants : HAPMAP8036
Genomic Variants (DGV)SHOC2 [DGVbeta]
DECIPHERSHOC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSHOC2 
Mutations
ICGC Data PortalSHOC2 
TCGA Data PortalSHOC2 
Broad Tumor PortalSHOC2
OASIS PortalSHOC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSHOC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSHOC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SHOC2
DgiDB (Drug Gene Interaction Database)SHOC2
DoCM (Curated mutations)SHOC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SHOC2 (select a term)
intoGenSHOC2
Cancer3DSHOC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602775    607721   
Orphanet2462   
MedgenSHOC2
Genetic Testing Registry SHOC2
NextProtQ9UQ13 [Medical]
TSGene8036
GENETestsSHOC2
Target ValidationSHOC2
Huge Navigator SHOC2 [HugePedia]
snp3D : Map Gene to Disease8036
BioCentury BCIQSHOC2
ClinGenSHOC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8036
Chemical/Pharm GKB GenePA37960
Clinical trialSHOC2
Miscellaneous
canSAR (ICR)SHOC2 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSHOC2
EVEXSHOC2
GoPubMedSHOC2
iHOPSHOC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:07:15 CEST 2017

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