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SIGIRR (single Ig and TIR domain containing)

Identity

Alias_namessingle immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Alias_symbol (synonym)TIR8
IL-1R8
Other alias
HGNC (Hugo) SIGIRR
LocusID (NCBI) 59307
Atlas_Id 55686
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 405716 and ends at 417397 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HGS (17q25.3) / SIGIRR (11p15.5)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIGIRR   30575
Cards
Entrez_Gene (NCBI)SIGIRR  59307  single Ig and TIR domain containing
AliasesIL-1R8; TIR8
GeneCards (Weizmann)SIGIRR
Ensembl hg19 (Hinxton)ENSG00000185187 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185187 [Gene_View]  ENSG00000185187 [Sequence]  chr11:405716-417397 [Contig_View]  SIGIRR [Vega]
ICGC DataPortalENSG00000185187
TCGA cBioPortalSIGIRR
AceView (NCBI)SIGIRR
Genatlas (Paris)SIGIRR
WikiGenes59307
SOURCE (Princeton)SIGIRR
Genetics Home Reference (NIH)SIGIRR
Genomic and cartography
GoldenPath hg38 (UCSC)SIGIRR  -     chr11:405716-417397 -  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIGIRR  -     11q23.3   [Description]    (hg19-Feb_2009)
EnsemblSIGIRR - 11q23.3 [CytoView hg19]  SIGIRR - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBISIGIRR [Mapview hg19]  SIGIRR [Mapview hg38]
OMIM605478   
Gene and transcription
Genbank (Entrez)AK025099 AK093427 AK172830 AY358342 BC003591
RefSeq transcript (Entrez)NM_001135053 NM_001135054 NM_021805
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIGIRR
Cluster EST : UnigeneHs.501624 [ NCBI ]
CGAP (NCI)Hs.501624
Alternative Splicing GalleryENSG00000185187
Gene ExpressionSIGIRR [ NCBI-GEO ]   SIGIRR [ EBI - ARRAY_EXPRESS ]   SIGIRR [ SEEK ]   SIGIRR [ MEM ]
Gene Expression Viewer (FireBrowse)SIGIRR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)59307
GTEX Portal (Tissue expression)SIGIRR
Human Protein AtlasENSG00000185187-SIGIRR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6IA17   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6IA17  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6IA17
Splice isoforms : SwissVarQ6IA17
PhosPhoSitePlusQ6IA17
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    TIR (PS50104)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    IL-1_rcpt_fam    TIR_dom    Toll_tir_struct_dom_sf   
Domain families : Pfam (Sanger)TIR (PF01582)   
Domain families : Pfam (NCBI)pfam01582   
Domain families : Smart (EMBL)TIR (SM00255)  
Conserved Domain (NCBI)SIGIRR
DMDM Disease mutations59307
Blocks (Seattle)SIGIRR
SuperfamilyQ6IA17
Human Protein Atlas [tissue]ENSG00000185187-SIGIRR [tissue]
Peptide AtlasQ6IA17
HPRD12018
IPIIPI00029155   IPI00432567   IPI00984952   IPI00952672   IPI00976234   IPI00983266   IPI00982596   IPI00983948   IPI00984312   
Protein Interaction databases
DIP (DOE-UCLA)Q6IA17
IntAct (EBI)Q6IA17
FunCoupENSG00000185187
BioGRIDSIGIRR
STRING (EMBL)SIGIRR
ZODIACSIGIRR
Ontologies - Pathways
QuickGOQ6IA17
Ontology : AmiGOnegative regulation of cytokine-mediated signaling pathway  protein binding  plasma membrane  acute-phase response  signal transduction  membrane  integral component of membrane  negative regulation of lipopolysaccharide-mediated signaling pathway  negative regulation of DNA-binding transcription factor activity  negative regulation of chemokine biosynthetic process  cellular response to cytokine stimulus  
Ontology : EGO-EBInegative regulation of cytokine-mediated signaling pathway  protein binding  plasma membrane  acute-phase response  signal transduction  membrane  integral component of membrane  negative regulation of lipopolysaccharide-mediated signaling pathway  negative regulation of DNA-binding transcription factor activity  negative regulation of chemokine biosynthetic process  cellular response to cytokine stimulus  
NDEx NetworkSIGIRR
Atlas of Cancer Signalling NetworkSIGIRR
Wikipedia pathwaysSIGIRR
Orthology - Evolution
OrthoDB59307
GeneTree (enSembl)ENSG00000185187
Phylogenetic Trees/Animal Genes : TreeFamSIGIRR
HOVERGENQ6IA17
HOGENOMQ6IA17
Homologs : HomoloGeneSIGIRR
Homology/Alignments : Family Browser (UCSC)SIGIRR
Gene fusions - Rearrangements
Fusion : QuiverSIGIRR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIGIRR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIGIRR
dbVarSIGIRR
ClinVarSIGIRR
1000_GenomesSIGIRR 
Exome Variant ServerSIGIRR
ExAC (Exome Aggregation Consortium)ENSG00000185187
GNOMAD BrowserENSG00000185187
Varsome BrowserSIGIRR
Genetic variants : HAPMAP59307
Genomic Variants (DGV)SIGIRR [DGVbeta]
DECIPHERSIGIRR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIGIRR 
Mutations
ICGC Data PortalSIGIRR 
TCGA Data PortalSIGIRR 
Broad Tumor PortalSIGIRR
OASIS PortalSIGIRR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIGIRR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIGIRR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIGIRR
DgiDB (Drug Gene Interaction Database)SIGIRR
DoCM (Curated mutations)SIGIRR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIGIRR (select a term)
intoGenSIGIRR
Cancer3DSIGIRR(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605478   
Orphanet
DisGeNETSIGIRR
MedgenSIGIRR
Genetic Testing Registry SIGIRR
NextProtQ6IA17 [Medical]
TSGene59307
GENETestsSIGIRR
Target ValidationSIGIRR
Huge Navigator SIGIRR [HugePedia]
snp3D : Map Gene to Disease59307
BioCentury BCIQSIGIRR
ClinGenSIGIRR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD59307
Chemical/Pharm GKB GenePA142670915
Clinical trialSIGIRR
Miscellaneous
canSAR (ICR)SIGIRR (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIGIRR
EVEXSIGIRR
GoPubMedSIGIRR
iHOPSIGIRR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Aug 16 11:31:39 CEST 2018

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