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SIGIRR (single Ig and TIR domain containing)

Identity

Alias (NCBI)IL-1R8
TIR8
HGNC (Hugo) SIGIRR
HGNC Alias symbTIR8
IL-1R8
HGNC Alias namesingle immunoglobulin domain IL1R1 related
HGNC Previous namesingle immunoglobulin and toll-interleukin 1 receptor (TIR) domain
LocusID (NCBI) 59307
Atlas_Id 55686
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 405716 and ends at 417397 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HGS (17q25.3) / SIGIRR (11p15.5)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SIGIRR   30575
Cards
Entrez_Gene (NCBI)SIGIRR    single Ig and TIR domain containing
AliasesIL-1R8; TIR8
GeneCards (Weizmann)SIGIRR
Ensembl hg19 (Hinxton)ENSG00000185187 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185187 [Gene_View]  ENSG00000185187 [Sequence]  chr11:405716-417397 [Contig_View]  SIGIRR [Vega]
ICGC DataPortalENSG00000185187
TCGA cBioPortalSIGIRR
AceView (NCBI)SIGIRR
Genatlas (Paris)SIGIRR
SOURCE (Princeton)SIGIRR
Genetics Home Reference (NIH)SIGIRR
Genomic and cartography
GoldenPath hg38 (UCSC)SIGIRR  -     chr11:405716-417397 -  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIGIRR  -     11p15.5   [Description]    (hg19-Feb_2009)
GoldenPathSIGIRR - 11p15.5 [CytoView hg19]  SIGIRR - 11p15.5 [CytoView hg38]
ImmunoBaseENSG00000185187
Genome Data Viewer NCBISIGIRR [Mapview hg19]  
OMIM605478   
Gene and transcription
Genbank (Entrez)AK025099 AK093427 AK172830 AY358342 BC003591
RefSeq transcript (Entrez)NM_001135053 NM_001135054 NM_021805
Consensus coding sequences : CCDS (NCBI)SIGIRR
Gene ExpressionSIGIRR [ NCBI-GEO ]   SIGIRR [ EBI - ARRAY_EXPRESS ]   SIGIRR [ SEEK ]   SIGIRR [ MEM ]
Gene Expression Viewer (FireBrowse)SIGIRR [ Firebrowse - Broad ]
GenevisibleExpression of SIGIRR in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)59307
GTEX Portal (Tissue expression)SIGIRR
Human Protein AtlasENSG00000185187-SIGIRR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6IA17   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6IA17  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6IA17
PhosPhoSitePlusQ6IA17
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    TIR (PS50104)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    IL-1_rcpt_fam    TIR_dom    Toll_tir_struct_dom_sf   
Domain families : Pfam (Sanger)TIR (PF01582)   
Domain families : Pfam (NCBI)pfam01582   
Domain families : Smart (EMBL)TIR (SM00255)  
Conserved Domain (NCBI)SIGIRR
SuperfamilyQ6IA17
AlphaFold pdb e-kbQ6IA17   
Human Protein Atlas [tissue]ENSG00000185187-SIGIRR [tissue]
HPRD12018
Protein Interaction databases
DIP (DOE-UCLA)Q6IA17
IntAct (EBI)Q6IA17
BioGRIDSIGIRR
STRING (EMBL)SIGIRR
ZODIACSIGIRR
Ontologies - Pathways
QuickGOQ6IA17
Ontology : AmiGOnegative regulation of cytokine-mediated signaling pathway  protein binding  plasma membrane  acute-phase response  signal transduction  membrane  integral component of membrane  negative regulation of lipopolysaccharide-mediated signaling pathway  negative regulation of chemokine production  negative regulation of DNA-binding transcription factor activity  cellular response to cytokine stimulus  
Ontology : EGO-EBInegative regulation of cytokine-mediated signaling pathway  protein binding  plasma membrane  acute-phase response  signal transduction  membrane  integral component of membrane  negative regulation of lipopolysaccharide-mediated signaling pathway  negative regulation of chemokine production  negative regulation of DNA-binding transcription factor activity  cellular response to cytokine stimulus  
NDEx NetworkSIGIRR
Atlas of Cancer Signalling NetworkSIGIRR
Wikipedia pathwaysSIGIRR
Orthology - Evolution
OrthoDB59307
GeneTree (enSembl)ENSG00000185187
Phylogenetic Trees/Animal Genes : TreeFamSIGIRR
Homologs : HomoloGeneSIGIRR
Homology/Alignments : Family Browser (UCSC)SIGIRR
Gene fusions - Rearrangements
Fusion : QuiverSIGIRR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIGIRR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIGIRR
dbVarSIGIRR
ClinVarSIGIRR
MonarchSIGIRR
1000_GenomesSIGIRR 
Exome Variant ServerSIGIRR
GNOMAD BrowserENSG00000185187
Varsome BrowserSIGIRR
ACMGSIGIRR variants
VarityQ6IA17
Genomic Variants (DGV)SIGIRR [DGVbeta]
DECIPHERSIGIRR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIGIRR 
Mutations
ICGC Data PortalSIGIRR 
TCGA Data PortalSIGIRR 
Broad Tumor PortalSIGIRR
OASIS PortalSIGIRR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIGIRR  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSIGIRR
Mutations and Diseases : HGMDSIGIRR
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSIGIRR
DgiDB (Drug Gene Interaction Database)SIGIRR
DoCM (Curated mutations)SIGIRR
CIViC (Clinical Interpretations of Variants in Cancer)SIGIRR
Cancer3DSIGIRR
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605478   
Orphanet
DisGeNETSIGIRR
MedgenSIGIRR
Genetic Testing Registry SIGIRR
NextProtQ6IA17 [Medical]
GENETestsSIGIRR
Target ValidationSIGIRR
Huge Navigator SIGIRR [HugePedia]
ClinGenSIGIRR
Clinical trials, drugs, therapy
MyCancerGenomeSIGIRR
Protein Interactions : CTDSIGIRR
Pharm GKB GenePA142670915
PharosQ6IA17
Clinical trialSIGIRR
Miscellaneous
canSAR (ICR)SIGIRR
HarmonizomeSIGIRR
DataMed IndexSIGIRR
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSIGIRR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:31:08 CEST 2021

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