SIGLEC10 (sialic acid binding Ig like lectin 10)

2015-05-01  

Identity

HGNC
SIGLEC10
LOCATION
19q13.41
LOCUSID
89790
ALIAS
PRO940,SIGLEC-10,SLG2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 89790
MIM: 606091
HGNC: 15620
Ensembl: ENSG00000142512

Variants:

dbSNP: 89790
ClinVar: 89790
TCGA: ENSG00000142512
COSMIC: SIGLEC10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142512ENST00000339313Q96LC7
ENSG00000142512ENST00000353836Q96LC7
ENSG00000142512ENST00000436984Q96LC7
ENSG00000142512ENST00000439889Q96LC7
ENSG00000142512ENST00000441969Q96LC7
ENSG00000142512ENST00000442846Q96LC7
ENSG00000142512ENST00000525998E9PL79
ENSG00000142512ENST00000529627E9PKV9
ENSG00000142512ENST00000530476E9PJA1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
313670432019CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.40
198616822009Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate.30
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
176729182007Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.17
254505982015Siglec-10 is associated with survival and natural killer cell dysfunction in hepatocellular carcinoma.10
299971732018CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function.3

Citation

Dessen P

SIGLEC10 (sialic acid binding Ig like lectin 10)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55220/siglec10