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SIGLEC12 (sialic acid binding Ig like lectin 12 (gene/pseudogene))

Identity

Alias_namesSIGLECL1
SIGLEC-like 1
sialic acid binding Ig-like lectin 12
sialic acid binding Ig-like lectin 12 (gene/pseudogene)
Alias_symbol (synonym)SLG
S2V
Siglec-XII
Siglec-12
Siglec-L1
Other alias
HGNC (Hugo) SIGLEC12
LocusID (NCBI) 89858
Atlas_Id 52383
Location 19q13.41  [Link to chromosome band 19q13]
Location_base_pair Starts at 51491227 and ends at 51500393 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MED25 (19q13.33) / SIGLEC12 (19q13.41)MED25 19q13.33 / SIGLEC12 19q13.41

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIGLEC12   15482
Cards
Entrez_Gene (NCBI)SIGLEC12  89858  sialic acid binding Ig like lectin 12 (gene/pseudogene)
AliasesS2V; SIGLECL1; SLG; Siglec-XII
GeneCards (Weizmann)SIGLEC12
Ensembl hg19 (Hinxton)ENSG00000254521 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000254521 [Gene_View]  chr19:51491227-51500393 [Contig_View]  SIGLEC12 [Vega]
ICGC DataPortalENSG00000254521
TCGA cBioPortalSIGLEC12
AceView (NCBI)SIGLEC12
Genatlas (Paris)SIGLEC12
WikiGenes89858
SOURCE (Princeton)SIGLEC12
Genetics Home Reference (NIH)SIGLEC12
Genomic and cartography
GoldenPath hg38 (UCSC)SIGLEC12  -     chr19:51491227-51500393 -  19q13.41   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIGLEC12  -     19q13.41   [Description]    (hg19-Feb_2009)
EnsemblSIGLEC12 - 19q13.41 [CytoView hg19]  SIGLEC12 - 19q13.41 [CytoView hg38]
Mapping of homologs : NCBISIGLEC12 [Mapview hg19]  SIGLEC12 [Mapview hg38]
OMIM606094   
Gene and transcription
Genbank (Entrez)AF282256 AI132995 AK095919 AK225931 AY358140
RefSeq transcript (Entrez)NM_033329 NM_053003
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIGLEC12
Cluster EST : UnigeneHs.249741 [ NCBI ]
CGAP (NCI)Hs.249741
Alternative Splicing GalleryENSG00000254521
Gene ExpressionSIGLEC12 [ NCBI-GEO ]   SIGLEC12 [ EBI - ARRAY_EXPRESS ]   SIGLEC12 [ SEEK ]   SIGLEC12 [ MEM ]
Gene Expression Viewer (FireBrowse)SIGLEC12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89858
GTEX Portal (Tissue expression)SIGLEC12
Human Protein AtlasENSG00000254521-SIGLEC12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PQ1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PQ1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PQ1
Splice isoforms : SwissVarQ96PQ1
PhosPhoSitePlusQ96PQ1
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    Ig_sub2    Ig_V-set   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)SIGLEC12
DMDM Disease mutations89858
Blocks (Seattle)SIGLEC12
SuperfamilyQ96PQ1
Human Protein Atlas [tissue]ENSG00000254521-SIGLEC12 [tissue]
Peptide AtlasQ96PQ1
HPRD16195
IPIIPI00071204   IPI00071917   
Protein Interaction databases
DIP (DOE-UCLA)Q96PQ1
IntAct (EBI)Q96PQ1
FunCoupENSG00000254521
BioGRIDSIGLEC12
STRING (EMBL)SIGLEC12
ZODIACSIGLEC12
Ontologies - Pathways
QuickGOQ96PQ1
Ontology : AmiGOcell adhesion  integral component of membrane  carbohydrate binding  
Ontology : EGO-EBIcell adhesion  integral component of membrane  carbohydrate binding  
NDEx NetworkSIGLEC12
Atlas of Cancer Signalling NetworkSIGLEC12
Wikipedia pathwaysSIGLEC12
Orthology - Evolution
OrthoDB89858
GeneTree (enSembl)ENSG00000254521
Phylogenetic Trees/Animal Genes : TreeFamSIGLEC12
HOVERGENQ96PQ1
HOGENOMQ96PQ1
Homologs : HomoloGeneSIGLEC12
Homology/Alignments : Family Browser (UCSC)SIGLEC12
Gene fusions - Rearrangements
Fusion : MitelmanMED25/SIGLEC12 [19q13.33/19q13.41]  [t(19;19)(q13;q13)]  
Fusion: TCGA_MDACCMED25 19q13.33 SIGLEC12 19q13.41 LUAD
Tumor Fusion PortalSIGLEC12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIGLEC12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIGLEC12
dbVarSIGLEC12
ClinVarSIGLEC12
1000_GenomesSIGLEC12 
Exome Variant ServerSIGLEC12
ExAC (Exome Aggregation Consortium)ENSG00000254521
GNOMAD BrowserENSG00000254521
Genetic variants : HAPMAP89858
Genomic Variants (DGV)SIGLEC12 [DGVbeta]
DECIPHERSIGLEC12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIGLEC12 
Mutations
ICGC Data PortalSIGLEC12 
TCGA Data PortalSIGLEC12 
Broad Tumor PortalSIGLEC12
OASIS PortalSIGLEC12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIGLEC12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIGLEC12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIGLEC12
DgiDB (Drug Gene Interaction Database)SIGLEC12
DoCM (Curated mutations)SIGLEC12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIGLEC12 (select a term)
intoGenSIGLEC12
Cancer3DSIGLEC12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606094   
Orphanet
DisGeNETSIGLEC12
MedgenSIGLEC12
Genetic Testing Registry SIGLEC12
NextProtQ96PQ1 [Medical]
TSGene89858
GENETestsSIGLEC12
Target ValidationSIGLEC12
Huge Navigator SIGLEC12 [HugePedia]
snp3D : Map Gene to Disease89858
BioCentury BCIQSIGLEC12
ClinGenSIGLEC12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD89858
Chemical/Pharm GKB GenePA37966
Clinical trialSIGLEC12
Miscellaneous
canSAR (ICR)SIGLEC12 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIGLEC12
EVEXSIGLEC12
GoPubMedSIGLEC12
iHOPSIGLEC12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:34:36 CET 2017

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