SIGLEC12 (sialic acid binding Ig like lectin 12)

2011-09-01  

Identity

HGNC
LOCATION
19q13.41
LOCUSID
ALIAS
S2V,SIGLECL1,SLG,Siglec-XII
FUSION GENES

Other Information

Locus ID:

NCBI: 89858
MIM: 606094
HGNC: 15482
Ensembl: ENSG00000254521

Variants:

dbSNP: 89858
ClinVar: 89858
TCGA: ENSG00000254521
COSMIC: SIGLEC12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000254521ENST00000291707Q96PQ1
ENSG00000254521ENST00000596742M0QYF3
ENSG00000254521ENST00000598614Q96PQ1

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
215555172011SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.15
236903422013Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11

Citation

Dessen P

SIGLEC12 (sialic acid binding Ig like lectin 12)

Atlas Genet Cytogenet Oncol Haematol. 2011-09-01

Online version: http://atlasgeneticsoncology.org/gene/52383/siglec12