SIGLEC15 (sialic acid binding Ig like lectin 15)

2013-07-01 Affiliation

Identity

HGNC

SIGLEC15

LOCATION

18q12.3

LOCUSID

284266

ALIAS

CD33L3,HsT1361,SIGLEC-15

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 284266
MIM: 618105
HGNC: 27596
Ensembl: ENSG00000197046

Variants:

dbSNP: 284266
ClinVar: 284266
TCGA: ENSG00000197046
COSMIC: SIGLEC15

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000197046	ENST00000389474	Q6ZMC9
ENSG00000197046	ENST00000546268	Q6ZMC9
ENSG00000197046	ENST00000587418	K7EN40

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127

References

Pubmed ID	Year	Title
23035012	2013	The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.
30833750	2019	Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy.
31900164	2020	Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases.

Citation

Dessen P

SIGLEC15 (sialic acid binding Ig like lectin 15)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53430/siglec15