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SIGLEC5 (sialic acid binding Ig like lectin 5)

Identity

Alias_namesCD33L2
sialic acid binding Ig-like lectin 5
Alias_symbol (synonym)OB-BP2
SIGLEC-5
CD170
Other aliasOBBP2
HGNC (Hugo) SIGLEC5
LocusID (NCBI) 8778
Atlas_Id 56013
Location 19q13.41  [Link to chromosome band 19q13]
Location_base_pair Starts at 51611503 and ends at 51630474 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIGLEC5   10874
Cards
Entrez_Gene (NCBI)SIGLEC5  8778  sialic acid binding Ig like lectin 5
AliasesCD170; CD33L2; OB-BP2; OBBP2; 
SIGLEC-5
GeneCards (Weizmann)SIGLEC5
Ensembl hg19 (Hinxton)ENSG00000105501 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105501 [Gene_View]  chr19:51611503-51630474 [Contig_View]  SIGLEC5 [Vega]
ICGC DataPortalENSG00000105501
TCGA cBioPortalSIGLEC5
AceView (NCBI)SIGLEC5
Genatlas (Paris)SIGLEC5
WikiGenes8778
SOURCE (Princeton)SIGLEC5
Genetics Home Reference (NIH)SIGLEC5
Genomic and cartography
GoldenPath hg38 (UCSC)SIGLEC5  -     chr19:51611503-51630474 -  19q13.41   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIGLEC5  -     19q13.41   [Description]    (hg19-Feb_2009)
EnsemblSIGLEC5 - 19q13.41 [CytoView hg19]  SIGLEC5 - 19q13.41 [CytoView hg38]
Mapping of homologs : NCBISIGLEC5 [Mapview hg19]  SIGLEC5 [Mapview hg38]
OMIM604200   
Gene and transcription
Genbank (Entrez)AF170484 AK225753 BC029896 BX106622 DC324223
RefSeq transcript (Entrez)NM_003830
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIGLEC5
Cluster EST : UnigeneHs.310333 [ NCBI ]
CGAP (NCI)Hs.310333
Alternative Splicing GalleryENSG00000105501
Gene ExpressionSIGLEC5 [ NCBI-GEO ]   SIGLEC5 [ EBI - ARRAY_EXPRESS ]   SIGLEC5 [ SEEK ]   SIGLEC5 [ MEM ]
Gene Expression Viewer (FireBrowse)SIGLEC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8778
GTEX Portal (Tissue expression)SIGLEC5
Human Protein AtlasENSG00000105501-SIGLEC5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15389   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15389  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15389
Splice isoforms : SwissVarO15389
PhosPhoSitePlusO15389
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    Ig_sub2    Ig_V-set   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)SIGLEC5
DMDM Disease mutations8778
Blocks (Seattle)SIGLEC5
PDB (SRS)2ZG1    2ZG2    2ZG3   
PDB (PDBSum)2ZG1    2ZG2    2ZG3   
PDB (IMB)2ZG1    2ZG2    2ZG3   
PDB (RSDB)2ZG1    2ZG2    2ZG3   
Structural Biology KnowledgeBase2ZG1    2ZG2    2ZG3   
SCOP (Structural Classification of Proteins)2ZG1    2ZG2    2ZG3   
CATH (Classification of proteins structures)2ZG1    2ZG2    2ZG3   
SuperfamilyO15389
Human Protein Atlas [tissue]ENSG00000105501-SIGLEC5 [tissue]
Peptide AtlasO15389
HPRD05011
IPIIPI00021935   
Protein Interaction databases
DIP (DOE-UCLA)O15389
IntAct (EBI)O15389
FunCoupENSG00000105501
BioGRIDSIGLEC5
STRING (EMBL)SIGLEC5
ZODIACSIGLEC5
Ontologies - Pathways
QuickGOO15389
Ontology : AmiGOprotein binding  plasma membrane  cell adhesion  integral component of membrane  carbohydrate binding  secretory granule membrane  neutrophil degranulation  tertiary granule membrane  ficolin-1-rich granule membrane  
Ontology : EGO-EBIprotein binding  plasma membrane  cell adhesion  integral component of membrane  carbohydrate binding  secretory granule membrane  neutrophil degranulation  tertiary granule membrane  ficolin-1-rich granule membrane  
NDEx NetworkSIGLEC5
Atlas of Cancer Signalling NetworkSIGLEC5
Wikipedia pathwaysSIGLEC5
Orthology - Evolution
OrthoDB8778
GeneTree (enSembl)ENSG00000105501
Phylogenetic Trees/Animal Genes : TreeFamSIGLEC5
HOVERGENO15389
HOGENOMO15389
Homologs : HomoloGeneSIGLEC5
Homology/Alignments : Family Browser (UCSC)SIGLEC5
Gene fusions - Rearrangements
Tumor Fusion PortalSIGLEC5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIGLEC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIGLEC5
dbVarSIGLEC5
ClinVarSIGLEC5
1000_GenomesSIGLEC5 
Exome Variant ServerSIGLEC5
ExAC (Exome Aggregation Consortium)ENSG00000105501
GNOMAD BrowserENSG00000105501
Genetic variants : HAPMAP8778
Genomic Variants (DGV)SIGLEC5 [DGVbeta]
DECIPHERSIGLEC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIGLEC5 
Mutations
ICGC Data PortalSIGLEC5 
TCGA Data PortalSIGLEC5 
Broad Tumor PortalSIGLEC5
OASIS PortalSIGLEC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIGLEC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIGLEC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIGLEC5
DgiDB (Drug Gene Interaction Database)SIGLEC5
DoCM (Curated mutations)SIGLEC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIGLEC5 (select a term)
intoGenSIGLEC5
Cancer3DSIGLEC5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604200   
Orphanet
DisGeNETSIGLEC5
MedgenSIGLEC5
Genetic Testing Registry SIGLEC5
NextProtO15389 [Medical]
TSGene8778
GENETestsSIGLEC5
Target ValidationSIGLEC5
Huge Navigator SIGLEC5 [HugePedia]
snp3D : Map Gene to Disease8778
BioCentury BCIQSIGLEC5
ClinGenSIGLEC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8778
Chemical/Pharm GKB GenePA35775
Clinical trialSIGLEC5
Miscellaneous
canSAR (ICR)SIGLEC5 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIGLEC5
EVEXSIGLEC5
GoPubMedSIGLEC5
iHOPSIGLEC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:34:36 CET 2017

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