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SIGLEC6 (sialic acid binding Ig like lectin 6)

Identity

Alias (NCBI)CD327
CD33L
CD33L1
CD33L2
CDW327
OBBP1
HGNC (Hugo) SIGLEC6
HGNC Alias symbOB-BP1
SIGLEC-6
CD327
HGNC Previous nameCD33L
 CD33L1
HGNC Previous namesialic acid binding Ig-like lectin 6
LocusID (NCBI) 946
Atlas_Id 56555
Location 19q13.41  [Link to chromosome band 19q13]
Location_base_pair Starts at 51517819 and ends at 51531670 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SIGLEC6   10875
Cards
Entrez_Gene (NCBI)SIGLEC6    sialic acid binding Ig like lectin 6
AliasesCD327; CD33L; CD33L1; CD33L2; 
CDW327; OBBP1
GeneCards (Weizmann)SIGLEC6
Ensembl hg19 (Hinxton)ENSG00000105492 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105492 [Gene_View]  ENSG00000105492 [Sequence]  chr19:51517819-51531670 [Contig_View]  SIGLEC6 [Vega]
ICGC DataPortalENSG00000105492
TCGA cBioPortalSIGLEC6
AceView (NCBI)SIGLEC6
Genatlas (Paris)SIGLEC6
SOURCE (Princeton)SIGLEC6
Genetics Home Reference (NIH)SIGLEC6
Genomic and cartography
GoldenPath hg38 (UCSC)SIGLEC6  -     chr19:51517819-51531670 -  19q13.41   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIGLEC6  -     19q13.41   [Description]    (hg19-Feb_2009)
GoldenPathSIGLEC6 - 19q13.41 [CytoView hg19]  SIGLEC6 - 19q13.41 [CytoView hg38]
ImmunoBaseENSG00000105492
Genome Data Viewer NCBISIGLEC6 [Mapview hg19]  
OMIM604405   
Gene and transcription
Genbank (Entrez)AK300170 AK300182 AK308174 AK309903 AU138048
RefSeq transcript (Entrez)NM_001177547 NM_001177548 NM_001177549 NM_001245 NM_198845 NM_198846
Consensus coding sequences : CCDS (NCBI)SIGLEC6
Gene ExpressionSIGLEC6 [ NCBI-GEO ]   SIGLEC6 [ EBI - ARRAY_EXPRESS ]   SIGLEC6 [ SEEK ]   SIGLEC6 [ MEM ]
Gene Expression Viewer (FireBrowse)SIGLEC6 [ Firebrowse - Broad ]
GenevisibleExpression of SIGLEC6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)946
GTEX Portal (Tissue expression)SIGLEC6
Human Protein AtlasENSG00000105492-SIGLEC6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43699   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43699  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43699
PhosPhoSitePlusO43699
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig/MHC_CS    Ig_I-set    Ig_sub    Ig_sub2    Ig_V-set    Immunoglobulin   
Domain families : Pfam (Sanger)I-set (PF07679)    ig (PF00047)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07679    pfam00047    pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)SIGLEC6
SuperfamilyO43699
AlphaFold pdb e-kbO43699   
Human Protein Atlas [tissue]ENSG00000105492-SIGLEC6 [tissue]
HPRD16058
Protein Interaction databases
DIP (DOE-UCLA)O43699
IntAct (EBI)O43699
BioGRIDSIGLEC6
STRING (EMBL)SIGLEC6
ZODIACSIGLEC6
Ontologies - Pathways
QuickGOO43699
Ontology : AmiGOprotein binding  extracellular region  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  cell adhesion  cell-cell signaling  membrane  carbohydrate binding  sialic acid binding  
Ontology : EGO-EBIprotein binding  extracellular region  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  cell adhesion  cell-cell signaling  membrane  carbohydrate binding  sialic acid binding  
NDEx NetworkSIGLEC6
Atlas of Cancer Signalling NetworkSIGLEC6
Wikipedia pathwaysSIGLEC6
Orthology - Evolution
OrthoDB946
GeneTree (enSembl)ENSG00000105492
Phylogenetic Trees/Animal Genes : TreeFamSIGLEC6
Homologs : HomoloGeneSIGLEC6
Homology/Alignments : Family Browser (UCSC)SIGLEC6
Gene fusions - Rearrangements
Fusion : QuiverSIGLEC6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIGLEC6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIGLEC6
dbVarSIGLEC6
ClinVarSIGLEC6
MonarchSIGLEC6
1000_GenomesSIGLEC6 
Exome Variant ServerSIGLEC6
GNOMAD BrowserENSG00000105492
Varsome BrowserSIGLEC6
ACMGSIGLEC6 variants
VarityO43699
Genomic Variants (DGV)SIGLEC6 [DGVbeta]
DECIPHERSIGLEC6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIGLEC6 
Mutations
ICGC Data PortalSIGLEC6 
TCGA Data PortalSIGLEC6 
Broad Tumor PortalSIGLEC6
OASIS PortalSIGLEC6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIGLEC6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSIGLEC6
Mutations and Diseases : HGMDSIGLEC6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSIGLEC6
DgiDB (Drug Gene Interaction Database)SIGLEC6
DoCM (Curated mutations)SIGLEC6
CIViC (Clinical Interpretations of Variants in Cancer)SIGLEC6
Cancer3DSIGLEC6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604405   
Orphanet
DisGeNETSIGLEC6
MedgenSIGLEC6
Genetic Testing Registry SIGLEC6
NextProtO43699 [Medical]
GENETestsSIGLEC6
Target ValidationSIGLEC6
Huge Navigator SIGLEC6 [HugePedia]
ClinGenSIGLEC6
Clinical trials, drugs, therapy
MyCancerGenomeSIGLEC6
Protein Interactions : CTDSIGLEC6
Pharm GKB GenePA35776
PharosO43699
Clinical trialSIGLEC6
Miscellaneous
canSAR (ICR)SIGLEC6
HarmonizomeSIGLEC6
ARCHS4SIGLEC6
DataMed IndexSIGLEC6
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSIGLEC6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:33:30 CET 2022

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