SIGLEC6 (sialic acid binding Ig like lectin 6)

2016-10-01  

Identity

HGNC
LOCATION
19q13.41
LOCUSID
ALIAS
CD327,CD33L,CD33L1,CD33L2,CDW327,OBBP1

Other Information

Locus ID:

NCBI: 946
MIM: 604405
HGNC: 10875
Ensembl: ENSG00000105492

Variants:

dbSNP: 946
ClinVar: 946
TCGA: ENSG00000105492
COSMIC: SIGLEC6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105492ENST00000343300O43699
ENSG00000105492ENST00000346477O43699
ENSG00000105492ENST00000359982O43699
ENSG00000105492ENST00000391797O43699
ENSG00000105492ENST00000425629O43699
ENSG00000105492ENST00000425629A0A024R4K4
ENSG00000105492ENST00000436458O43699

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188182962009Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2.62
175803162007Human-specific expression of Siglec-6 in the placenta.42
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
218807222011Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway.11
230891402012Siglec-6 is expressed in gestational trophoblastic disease and affects proliferation, apoptosis and invasion.5
231716842013Siglec-6 expression is increased in placentas from pregnancies complicated by preterm preeclampsia.4
302943272018Functional Inhibitory Siglec-6 Is Upregulated in Human Colorectal Cancer-Associated Mast Cells.2

Citation

Dessen P

SIGLEC6 (sialic acid binding Ig like lectin 6)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56555/siglec6