SIGLEC7 (sialic acid binding Ig like lectin 7)

2007-02-01  

Identity

HGNC
LOCATION
19q13.41
LOCUSID
ALIAS
AIRM-1,AIRM1,CD328,CDw328,D-siglec,QA79,SIGLEC-7,SIGLEC19P,SIGLECP2,p75,p75/AIRM1

Other Information

Locus ID:

NCBI: 27036
MIM: 604410
HGNC: 10876
Ensembl: ENSG00000168995

Variants:

dbSNP: 27036
ClinVar: 27036
TCGA: ENSG00000168995
COSMIC: SIGLEC7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168995ENST00000305628Q9Y286
ENSG00000168995ENST00000317643Q9Y286
ENSG00000168995ENST00000536156Q9Y286
ENSG00000168995ENST00000600577Q9Y286
ENSG00000168995ENST00000601682M0QY65

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
245694532014Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.76
127784822003Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms.65
155571782004The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells.60
152922622004Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9.51
197105022009The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia.48
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
124383152003High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family.26
166236612006The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design.22
168288662007Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors.17
230292612012Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes.15

Citation

Dessen P

SIGLEC7 (sialic acid binding Ig like lectin 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45703/siglec7