Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 27181
MIM: 605639
HGNC: 10877
Ensembl: ENSG00000105366
Variants:
dbSNP: 27181
ClinVar: 27181
TCGA: ENSG00000105366
COSMIC: SIGLEC8
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000105366 | ENST00000321424 | Q9NYZ4 |
| ENSG00000105366 | ENST00000340550 | Q9NYZ4 |
| ENSG00000105366 | ENST00000430817 | C9JT30 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Adaptive Immune System | REACTOME | R-HSA-1280218 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | REACTOME | R-HSA-198933 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33670444 | 2021 | First Evidence for a Role of Siglec-8 in Breast Cancer. | 3 |
| 33755113 | 2021 | Induction of the endogenous sialoglycan ligand for eosinophil death receptor Siglec-8 in chronic rhinosinusitis with hyperplastic nasal polyposis. | 5 |
| 33670444 | 2021 | First Evidence for a Role of Siglec-8 in Breast Cancer. | 3 |
| 33755113 | 2021 | Induction of the endogenous sialoglycan ligand for eosinophil death receptor Siglec-8 in chronic rhinosinusitis with hyperplastic nasal polyposis. | 5 |
| 32077788 | 2020 | Promoter region single nucleotide polymorphism of siglec-8 gene associates with susceptibility to allergic asthma. | 4 |
| 32077788 | 2020 | Promoter region single nucleotide polymorphism of siglec-8 gene associates with susceptibility to allergic asthma. | 4 |
| 30543818 | 2019 | Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies. | 24 |
| 30543818 | 2019 | Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies. | 24 |
| 28734845 | 2018 | Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells. | 31 |
| 28888781 | 2018 | Sialic acid-binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β(2)-integrin-dependent function in human eosinophils. | 29 |
| 28734845 | 2018 | Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells. | 31 |
| 28888781 | 2018 | Sialic acid-binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β(2)-integrin-dependent function in human eosinophils. | 29 |
| 26694037 | 2016 | Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression. | 15 |
| 26883254 | 2016 | Decreased expression of Siglec-8 associates with poor prognosis in patients with gastric cancer after surgical resection. | 5 |
| 27154355 | 2016 | Olig2 is expressed late in human eosinophil development and controls Siglec-8 expression. | 10 |
Citation
Dessen P
SIGLEC8 (sialic acid binding Ig like lectin 8)
Atlas Genet Cytogenet Oncol Haematol. 2012-04-01
Online version: http://atlasgeneticsoncology.org/gene/52676/siglec8
