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SIGLEC8 (sialic acid binding Ig like lectin 8)

Identity

Alias_namessialic acid binding Ig-like lectin 8
Alias_symbol (synonym)SIGLEC-8
SAF2
SIGLEC8L
MGC59785
Other alias
HGNC (Hugo) SIGLEC8
LocusID (NCBI) 27181
Atlas_Id 52676
Location 19q13.41  [Link to chromosome band 19q13]
Location_base_pair Starts at 51450997 and ends at 51458454 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIGLEC8   10877
Cards
Entrez_Gene (NCBI)SIGLEC8  27181  sialic acid binding Ig like lectin 8
AliasesSAF2; SIGLEC-8; SIGLEC8L
GeneCards (Weizmann)SIGLEC8
Ensembl hg19 (Hinxton)ENSG00000105366 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105366 [Gene_View]  chr19:51450997-51458454 [Contig_View]  SIGLEC8 [Vega]
ICGC DataPortalENSG00000105366
TCGA cBioPortalSIGLEC8
AceView (NCBI)SIGLEC8
Genatlas (Paris)SIGLEC8
WikiGenes27181
SOURCE (Princeton)SIGLEC8
Genetics Home Reference (NIH)SIGLEC8
Genomic and cartography
GoldenPath hg38 (UCSC)SIGLEC8  -     chr19:51450997-51458454 -  19q13.41   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIGLEC8  -     19q13.41   [Description]    (hg19-Feb_2009)
EnsemblSIGLEC8 - 19q13.41 [CytoView hg19]  SIGLEC8 - 19q13.41 [CytoView hg38]
Mapping of homologs : NCBISIGLEC8 [Mapview hg19]  SIGLEC8 [Mapview hg38]
OMIM605639   
Gene and transcription
Genbank (Entrez)AF195092 AF223403 AF310234 AK290149 AK290412
RefSeq transcript (Entrez)NM_014442
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIGLEC8
Cluster EST : UnigeneHs.447899 [ NCBI ]
CGAP (NCI)Hs.447899
Alternative Splicing GalleryENSG00000105366
Gene ExpressionSIGLEC8 [ NCBI-GEO ]   SIGLEC8 [ EBI - ARRAY_EXPRESS ]   SIGLEC8 [ SEEK ]   SIGLEC8 [ MEM ]
Gene Expression Viewer (FireBrowse)SIGLEC8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27181
GTEX Portal (Tissue expression)SIGLEC8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYZ4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYZ4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYZ4
Splice isoforms : SwissVarQ9NYZ4
PhosPhoSitePlusQ9NYZ4
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    Ig_sub2    Ig_V-set   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)SIGLEC8
DMDM Disease mutations27181
Blocks (Seattle)SIGLEC8
PDB (SRS)2N7A    2N7B   
PDB (PDBSum)2N7A    2N7B   
PDB (IMB)2N7A    2N7B   
PDB (RSDB)2N7A    2N7B   
Structural Biology KnowledgeBase2N7A    2N7B   
SCOP (Structural Classification of Proteins)2N7A    2N7B   
CATH (Classification of proteins structures)2N7A    2N7B   
SuperfamilyQ9NYZ4
Human Protein AtlasENSG00000105366
Peptide AtlasQ9NYZ4
HPRD16132
IPIIPI00171647   IPI00220653   IPI00220654   IPI00943199   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYZ4
IntAct (EBI)Q9NYZ4
FunCoupENSG00000105366
BioGRIDSIGLEC8
STRING (EMBL)SIGLEC8
ZODIACSIGLEC8
Ontologies - Pathways
QuickGOQ9NYZ4
Ontology : AmiGOtransmembrane signaling receptor activity  protein binding  cell adhesion  signal transduction  integral component of membrane  carbohydrate binding  
Ontology : EGO-EBItransmembrane signaling receptor activity  protein binding  cell adhesion  signal transduction  integral component of membrane  carbohydrate binding  
NDEx NetworkSIGLEC8
Atlas of Cancer Signalling NetworkSIGLEC8
Wikipedia pathwaysSIGLEC8
Orthology - Evolution
OrthoDB27181
GeneTree (enSembl)ENSG00000105366
Phylogenetic Trees/Animal Genes : TreeFamSIGLEC8
HOVERGENQ9NYZ4
HOGENOMQ9NYZ4
Homologs : HomoloGeneSIGLEC8
Homology/Alignments : Family Browser (UCSC)SIGLEC8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIGLEC8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIGLEC8
dbVarSIGLEC8
ClinVarSIGLEC8
1000_GenomesSIGLEC8 
Exome Variant ServerSIGLEC8
ExAC (Exome Aggregation Consortium)SIGLEC8 (select the gene name)
Genetic variants : HAPMAP27181
Genomic Variants (DGV)SIGLEC8 [DGVbeta]
DECIPHERSIGLEC8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIGLEC8 
Mutations
ICGC Data PortalSIGLEC8 
TCGA Data PortalSIGLEC8 
Broad Tumor PortalSIGLEC8
OASIS PortalSIGLEC8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIGLEC8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIGLEC8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIGLEC8
DgiDB (Drug Gene Interaction Database)SIGLEC8
DoCM (Curated mutations)SIGLEC8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIGLEC8 (select a term)
intoGenSIGLEC8
Cancer3DSIGLEC8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605639   
Orphanet
MedgenSIGLEC8
Genetic Testing Registry SIGLEC8
NextProtQ9NYZ4 [Medical]
TSGene27181
GENETestsSIGLEC8
Target ValidationSIGLEC8
Huge Navigator SIGLEC8 [HugePedia]
snp3D : Map Gene to Disease27181
BioCentury BCIQSIGLEC8
ClinGenSIGLEC8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27181
Chemical/Pharm GKB GenePA35778
Clinical trialSIGLEC8
Miscellaneous
canSAR (ICR)SIGLEC8 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIGLEC8
EVEXSIGLEC8
GoPubMedSIGLEC8
iHOPSIGLEC8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:07:17 CEST 2017

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