SIGLEC8 (sialic acid binding Ig like lectin 8)

2012-04-01  

Identity

HGNC
SIGLEC8
LOCATION
19q13.41
LOCUSID
27181
ALIAS
SAF2,SIGLEC-8,SIGLEC8L

Other Information

Locus ID:

NCBI: 27181
MIM: 605639
HGNC: 10877
Ensembl: ENSG00000105366

Variants:

dbSNP: 27181
ClinVar: 27181
TCGA: ENSG00000105366
COSMIC: SIGLEC8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105366ENST00000321424Q9NYZ4
ENSG00000105366ENST00000340550Q9NYZ4
ENSG00000105366ENST00000430817C9JT30

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
155634662005Glycan array screening reveals a candidate ligand for Siglec-8.91
126098312003Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis.88
191785372009Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors.58
180366502008Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement.40
176903262008Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathways.38
194581052009Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic Siglec-8 ligand, polymeric 6'-sulfated sialyl Lewis x.33
161573032005Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury.31
236840722013Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation.31
220793342012IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils.30
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27

Citation

Dessen P

SIGLEC8 (sialic acid binding Ig like lectin 8)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52676/siglec8