Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SIK1 (salt inducible kinase 1)

Identity

Alias_namesSNF1LK
SNF1-like kinase
Alias_symbol (synonym)msk
Other aliasEIEE30
MSK
SIK
HGNC (Hugo) SIK1
LocusID (NCBI) 150094
Atlas_Id 43496
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 44834398 and ends at 44847002 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDH1 (16q22.1) / SIK1 (21q22.3)SIK1 (21q22.3) / FSCN1 (7p22.1)SIK1 (21q22.3) / HUNK (21q22.11)
ZEB1 (10p11.22) / SIK1 (21q22.3)SIK1 21q22.3 / HUNK 21q22.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIK1   11142
Cards
Entrez_Gene (NCBI)SIK1  150094  salt inducible kinase 1
AliasesEIEE30; MSK; SIK; SNF1LK
GeneCards (Weizmann)SIK1
Ensembl hg19 (Hinxton)ENSG00000142178 [Gene_View]  chr21:44834398-44847002 [Contig_View]  SIK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000142178 [Gene_View]  chr21:44834398-44847002 [Contig_View]  SIK1 [Vega]
ICGC DataPortalENSG00000142178
TCGA cBioPortalSIK1
AceView (NCBI)SIK1
Genatlas (Paris)SIK1
WikiGenes150094
SOURCE (Princeton)SIK1
Genetics Home Reference (NIH)SIK1
Genomic and cartography
GoldenPath hg19 (UCSC)SIK1  -     chr21:44834398-44847002 -  21q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SIK1  -     21q22.3   [Description]    (hg38-Dec_2013)
EnsemblSIK1 - 21q22.3 [CytoView hg19]  SIK1 - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBISIK1 [Mapview hg19]  SIK1 [Mapview hg38]
OMIM605705   616341   
Gene and transcription
Genbank (Entrez)AB047786 AI073528 BM840872 CF528907 DQ892466
RefSeq transcript (Entrez)NM_173354
RefSeq genomic (Entrez)NC_000021 NT_011512
Consensus coding sequences : CCDS (NCBI)SIK1
Cluster EST : UnigeneHs.700423 [ NCBI ]
CGAP (NCI)Hs.700423
Alternative Splicing GalleryENSG00000142178
Gene ExpressionSIK1 [ NCBI-GEO ]   SIK1 [ EBI - ARRAY_EXPRESS ]   SIK1 [ SEEK ]   SIK1 [ MEM ]
Gene Expression Viewer (FireBrowse)SIK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)150094
GTEX Portal (Tissue expression)SIK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57059   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57059  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57059
Splice isoforms : SwissVarP57059
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusP57059
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    UBA (PS50030)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS    Ser/Thr_kinase_SIK1/2    UBA   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  UBA (SM00165)  
Conserved Domain (NCBI)SIK1
DMDM Disease mutations150094
Blocks (Seattle)SIK1
SuperfamilyP57059
Human Protein AtlasENSG00000142178
Peptide AtlasP57059
HPRD09301
IPIIPI00025679   
Protein Interaction databases
DIP (DOE-UCLA)P57059
IntAct (EBI)P57059
FunCoupENSG00000142178
BioGRIDSIK1
STRING (EMBL)SIK1
ZODIACSIK1
Ontologies - Pathways
QuickGOP57059
Ontology : AmiGOmagnesium ion binding  magnesium ion binding  regulation of sodium ion transport  protein serine/threonine kinase activity  protein binding  ATP binding  ATP binding  nucleus  cytoplasm  cytoplasm  protein phosphorylation  protein phosphorylation  cell cycle  regulation of mitotic cell cycle  cAMP response element binding protein binding  regulation of myotube differentiation  negative regulation of triglyceride biosynthetic process  protein kinase binding  negative regulation of CREB transcription factor activity  cellular response to hormone stimulus  intracellular signal transduction  intracellular signal transduction  entrainment of circadian clock by photoperiod  regulation of cell differentiation  negative regulation of gluconeogenesis  protein autophosphorylation  rhythmic process  cardiac muscle cell differentiation  14-3-3 protein binding  positive regulation of anoikis  
Ontology : EGO-EBImagnesium ion binding  magnesium ion binding  regulation of sodium ion transport  protein serine/threonine kinase activity  protein binding  ATP binding  ATP binding  nucleus  cytoplasm  cytoplasm  protein phosphorylation  protein phosphorylation  cell cycle  regulation of mitotic cell cycle  cAMP response element binding protein binding  regulation of myotube differentiation  negative regulation of triglyceride biosynthetic process  protein kinase binding  negative regulation of CREB transcription factor activity  cellular response to hormone stimulus  intracellular signal transduction  intracellular signal transduction  entrainment of circadian clock by photoperiod  regulation of cell differentiation  negative regulation of gluconeogenesis  protein autophosphorylation  rhythmic process  cardiac muscle cell differentiation  14-3-3 protein binding  positive regulation of anoikis  
NDEx NetworkSIK1
Atlas of Cancer Signalling NetworkSIK1
Wikipedia pathwaysSIK1
Orthology - Evolution
OrthoDB150094
GeneTree (enSembl)ENSG00000142178
Phylogenetic Trees/Animal Genes : TreeFamSIK1
HOVERGENP57059
HOGENOMP57059
Homologs : HomoloGeneSIK1
Homology/Alignments : Family Browser (UCSC)SIK1
Gene fusions - Rearrangements
Fusion : MitelmanSIK1/HUNK [21q22.3/21q22.11]  
Fusion: TCGASIK1 21q22.3 HUNK 21q22.11 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIK1
dbVarSIK1
ClinVarSIK1
1000_GenomesSIK1 
Exome Variant ServerSIK1
ExAC (Exome Aggregation Consortium)SIK1 (select the gene name)
Genetic variants : HAPMAP150094
Genomic Variants (DGV)SIK1 [DGVbeta]
DECIPHER (Syndromes)21:44834398-44847002  ENSG00000142178
CONAN: Copy Number AnalysisSIK1 
Mutations
ICGC Data PortalSIK1 
TCGA Data PortalSIK1 
Broad Tumor PortalSIK1
OASIS PortalSIK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIK1
DgiDB (Drug Gene Interaction Database)SIK1
DoCM (Curated mutations)SIK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIK1 (select a term)
intoGenSIK1
Cancer3DSIK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605705    616341   
Orphanet889    890    894   
MedgenSIK1
Genetic Testing Registry SIK1
NextProtP57059 [Medical]
TSGene150094
GENETestsSIK1
Huge Navigator SIK1 [HugePedia]
snp3D : Map Gene to Disease150094
BioCentury BCIQSIK1
ClinGenSIK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD150094
Chemical/Pharm GKB GenePA164725717
Clinical trialSIK1
Miscellaneous
canSAR (ICR)SIK1 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIK1
EVEXSIK1
GoPubMedSIK1
iHOPSIK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:19:18 CEST 2017

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