Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SIK1 (salt inducible kinase 1)

Identity

Alias (NCBI)DEE30
MSK
SIK
SIK-1
SIK1B
SNF1LK
HGNC (Hugo) SIK1
HGNC Alias symbmsk
HGNC Alias namemyocardial SNF1-like kinase
HGNC Previous nameSNF1LK
HGNC Previous nameSNF1-like kinase
LocusID (NCBI) 150094
Atlas_Id 43496
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 43414483 and ends at 43427131 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDH1 (16q22.1) / SIK1 (21q22.3)SIK1 (21q22.3) / FSCN1 (7p22.1)SIK1 (21q22.3) / HUNK (21q22.11)
ZEB1 (10p11.22) / SIK1 (21q22.3)SIK1 21q22.3 / HUNK 21q22.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)SIK1   11142
Cards
Entrez_Gene (NCBI)SIK1    salt inducible kinase 1
AliasesDEE30; MSK; SIK; SIK-1; 
SIK1B; SNF1LK
GeneCards (Weizmann)SIK1
Ensembl hg19 (Hinxton)ENSG00000142178 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142178 [Gene_View]  ENSG00000142178 [Sequence]  chr21:43414483-43427131 [Contig_View]  SIK1 [Vega]
ICGC DataPortalENSG00000142178
TCGA cBioPortalSIK1
AceView (NCBI)SIK1
Genatlas (Paris)SIK1
SOURCE (Princeton)SIK1
Genetics Home Reference (NIH)SIK1
Genomic and cartography
GoldenPath hg38 (UCSC)SIK1  -     chr21:43414483-43427131 -  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIK1  -     21q22.3   [Description]    (hg19-Feb_2009)
GoldenPathSIK1 - 21q22.3 [CytoView hg19]  SIK1 - 21q22.3 [CytoView hg38]
ImmunoBaseENSG00000142178
Genome Data Viewer NCBISIK1 [Mapview hg19]  
OMIM605705   616341   
Gene and transcription
Genbank (Entrez)AB047786 AI073528 BM840872 CF528907 HY008464
RefSeq transcript (Entrez)NM_173354
Consensus coding sequences : CCDS (NCBI)SIK1
Gene ExpressionSIK1 [ NCBI-GEO ]   SIK1 [ EBI - ARRAY_EXPRESS ]   SIK1 [ SEEK ]   SIK1 [ MEM ]
Gene Expression Viewer (FireBrowse)SIK1 [ Firebrowse - Broad ]
GenevisibleExpression of SIK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)150094
GTEX Portal (Tissue expression)SIK1
Human Protein AtlasENSG00000142178-SIK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57059   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57059  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57059
PhosPhoSitePlusP57059
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    UBA (PS50030)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    Ser/Thr_kinase_SIK1/2    SIK    UBA   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)SIK1
SuperfamilyP57059
AlphaFold pdb e-kbP57059   
Human Protein Atlas [tissue]ENSG00000142178-SIK1 [tissue]
HPRD09301
Protein Interaction databases
DIP (DOE-UCLA)P57059
IntAct (EBI)P57059
BioGRIDSIK1
STRING (EMBL)SIK1
ZODIACSIK1
Ontologies - Pathways
QuickGOP57059
Ontology : AmiGOmagnesium ion binding  magnesium ion binding  regulation of sodium ion transport  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  ATP binding  nucleus  nucleus  cytoplasm  cytoplasm  cytoplasm  protein phosphorylation  protein phosphorylation  protein phosphorylation  cell cycle  regulation of mitotic cell cycle  cAMP response element binding protein binding  regulation of myotube differentiation  negative regulation of triglyceride biosynthetic process  protein kinase binding  negative regulation of CREB transcription factor activity  intracellular signal transduction  intracellular signal transduction  intracellular signal transduction  cellular response to glucose starvation  entrainment of circadian clock by photoperiod  regulation of cell differentiation  negative regulation of gluconeogenesis  protein autophosphorylation  rhythmic process  cardiac muscle cell differentiation  14-3-3 protein binding  protein serine kinase activity  protein threonine kinase activity  positive regulation of anoikis  
Ontology : EGO-EBImagnesium ion binding  magnesium ion binding  regulation of sodium ion transport  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  ATP binding  nucleus  nucleus  cytoplasm  cytoplasm  cytoplasm  protein phosphorylation  protein phosphorylation  protein phosphorylation  cell cycle  regulation of mitotic cell cycle  cAMP response element binding protein binding  regulation of myotube differentiation  negative regulation of triglyceride biosynthetic process  protein kinase binding  negative regulation of CREB transcription factor activity  intracellular signal transduction  intracellular signal transduction  intracellular signal transduction  cellular response to glucose starvation  entrainment of circadian clock by photoperiod  regulation of cell differentiation  negative regulation of gluconeogenesis  protein autophosphorylation  rhythmic process  cardiac muscle cell differentiation  14-3-3 protein binding  protein serine kinase activity  protein threonine kinase activity  positive regulation of anoikis  
NDEx NetworkSIK1
Atlas of Cancer Signalling NetworkSIK1
Wikipedia pathwaysSIK1
Orthology - Evolution
OrthoDB150094
GeneTree (enSembl)ENSG00000142178
Phylogenetic Trees/Animal Genes : TreeFamSIK1
Homologs : HomoloGeneSIK1
Homology/Alignments : Family Browser (UCSC)SIK1
Gene fusions - Rearrangements
Fusion : MitelmanSIK1/HUNK [21q22.3/21q22.11]  
Fusion : QuiverSIK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIK1
dbVarSIK1
ClinVarSIK1
MonarchSIK1
1000_GenomesSIK1 
Exome Variant ServerSIK1
GNOMAD BrowserENSG00000142178
Varsome BrowserSIK1
ACMGSIK1 variants
VarityP57059
Genomic Variants (DGV)SIK1 [DGVbeta]
DECIPHERSIK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIK1 
Mutations
ICGC Data PortalSIK1 
TCGA Data PortalSIK1 
Broad Tumor PortalSIK1
OASIS PortalSIK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSIK1
Mutations and Diseases : HGMDSIK1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSIK1
DgiDB (Drug Gene Interaction Database)SIK1
DoCM (Curated mutations)SIK1
CIViC (Clinical Interpretations of Variants in Cancer)SIK1
Cancer3DSIK1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605705    616341   
Orphanet889    890    894   
DisGeNETSIK1
MedgenSIK1
Genetic Testing Registry SIK1
NextProtP57059 [Medical]
GENETestsSIK1
Target ValidationSIK1
Huge Navigator SIK1 [HugePedia]
ClinGenSIK1
Clinical trials, drugs, therapy
MyCancerGenomeSIK1
Protein Interactions : CTDSIK1
Pharm GKB GenePA164725717
PharosP57059
Clinical trialSIK1
Miscellaneous
canSAR (ICR)SIK1
HarmonizomeSIK1
DataMed IndexSIK1
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSIK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:31:10 CEST 2021
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