Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SIK3 (SIK family kinase 3)

Identity

Alias (NCBI)L19
QSK
SEMDK
SIK-3
HGNC (Hugo) SIK3
HGNC Alias symbFLJ12240
L19
KIAA0999
QSK
LocusID (NCBI) 23387
Atlas_Id 51135
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 116843410 and ends at 117098428 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKMY1 (2q37.3) / SIK3 (11q23.3)ARHGEF12 (11q23.3) / SIK3 (11q23.3)IQCA1 (2q37.2) / SIK3 (11q23.3)
NDFIP1 (5q31.3) / SIK3 (11q23.3)PPP2R1B (11q23.1) / SIK3 (11q23.3)SIK3 (11q23.3) / C11orf1 (11q23.1)
SIK3 (11q23.3) / CD3D (11q23.3)SIK3 (11q23.3) / GBP1 (1p22.2)SIK3 (11q23.3) / LOC550643 ()
SIK3 (11q23.3) / NBPF11 (1q21.1)SIK3 (11q23.3) / PCSK7 (11q23.3)SIK3 (11q23.3) / PPP1R1B (17q12)
SIK3 (11q23.3) / SFMBT2 (10p14)SIK3 (11q23.3) / SIK3 (11q23.3)SIK3 (11q23.3) / SPATS2L (2q33.1)
SIK3 (11q23.3) / TRIOBP (22q13.1)ARHGEF12 11q23.3 / SIK3 11q23.3SIK3 11q23.3 / C11orf1 11q23.1
SIK3 11q23.3 / CD3D 11q23.3SIK3 11q23.3 / PPP1R1B 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(5;11)(q11;q23) MTREX/SIK3
t(11;11)(q23;q23) C11orf1/SIK3
t(11;11)(q23;q23) PPP2R1B/SIK3
t(11;11)(q23;q23) SIK3/C11orf1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(1;11)(p36;q23) SIK3/CTNNBIP1
ARHGEF12/SIK3 (11q23)
SIK3/CD3D (11q23)
t(11;17)(q23;q12) SIK3/PPP1R1B

External links

Nomenclature
HGNC (Hugo)SIK3   29165
Cards
Entrez_Gene (NCBI)SIK3    SIK family kinase 3
AliasesL19; QSK; SEMDK; SIK-3
GeneCards (Weizmann)SIK3
Ensembl hg19 (Hinxton)ENSG00000160584 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160584 [Gene_View]  ENSG00000160584 [Sequence]  chr11:116843410-117098428 [Contig_View]  SIK3 [Vega]
ICGC DataPortalENSG00000160584
TCGA cBioPortalSIK3
AceView (NCBI)SIK3
Genatlas (Paris)SIK3
SOURCE (Princeton)SIK3
Genetics Home Reference (NIH)SIK3
Genomic and cartography
GoldenPath hg38 (UCSC)SIK3  -     chr11:116843410-117098428 -  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIK3  -     11q23.3   [Description]    (hg19-Feb_2009)
GoldenPathSIK3 - 11q23.3 [CytoView hg19]  SIK3 - 11q23.3 [CytoView hg38]
ImmunoBaseENSG00000160584
genome Data Viewer NCBISIK3 [Mapview hg19]  
OMIM614776   618162   
Gene and transcription
Genbank (Entrez)AA044062 AB209327 AI369377 AI479678 AI765994
RefSeq transcript (Entrez)NM_001281748 NM_001281749 NM_001366686 NM_001366687 NM_025164
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIK3
Alternative Splicing GalleryENSG00000160584
Gene ExpressionSIK3 [ NCBI-GEO ]   SIK3 [ EBI - ARRAY_EXPRESS ]   SIK3 [ SEEK ]   SIK3 [ MEM ]
Gene Expression Viewer (FireBrowse)SIK3 [ Firebrowse - Broad ]
GenevisibleExpression of SIK3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23387
GTEX Portal (Tissue expression)SIK3
Human Protein AtlasENSG00000160584-SIK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2K2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2K2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2K2
Splice isoforms : SwissVarQ9Y2K2
PhosPhoSitePlusQ9Y2K2
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    UBA (PS50030)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    SIK    UBA   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)SIK3
Blocks (Seattle)SIK3
SuperfamilyQ9Y2K2
Human Protein Atlas [tissue]ENSG00000160584-SIK3 [tissue]
Peptide AtlasQ9Y2K2
HPRD11121
IPIIPI00790605   IPI00657662   IPI01013522   IPI01011111   IPI00658144   IPI00032263   IPI00657720   IPI00879469   IPI00893836   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2K2
IntAct (EBI)Q9Y2K2
BioGRIDSIK3
STRING (EMBL)SIK3
ZODIACSIK3
Ontologies - Pathways
QuickGOQ9Y2K2
Ontology : AmiGOmicrotubule cytoskeleton organization  magnesium ion binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  intracellular signal transduction  tau-protein kinase activity  positive regulation of TORC1 signaling  positive regulation of TORC2 signaling  
Ontology : EGO-EBImicrotubule cytoskeleton organization  magnesium ion binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  intracellular signal transduction  tau-protein kinase activity  positive regulation of TORC1 signaling  positive regulation of TORC2 signaling  
NDEx NetworkSIK3
Atlas of Cancer Signalling NetworkSIK3
Wikipedia pathwaysSIK3
Orthology - Evolution
OrthoDB23387
GeneTree (enSembl)ENSG00000160584
Phylogenetic Trees/Animal Genes : TreeFamSIK3
HOGENOMQ9Y2K2
Homologs : HomoloGeneSIK3
Homology/Alignments : Family Browser (UCSC)SIK3
Gene fusions - Rearrangements
Fusion : MitelmanARHGEF12/SIK3 [11q23.3/11q23.3]  
Fusion : MitelmanPPP2R1B/SIK3 [11q23.1/11q23.3]  
Fusion : MitelmanSIK3/C11orf1 [11q23.3/11q23.1]  
Fusion : MitelmanSIK3/CD3D [11q23.3/11q23.3]  
Fusion : MitelmanSIK3/PPP1R1B [11q23.3/17q12]  
Fusion PortalARHGEF12 11q23.3 SIK3 11q23.3 BRCA
Fusion PortalSIK3 11q23.3 C11orf1 11q23.1 LAML
Fusion PortalSIK3 11q23.3 CD3D 11q23.3 LUAD
Fusion PortalSIK3 11q23.3 PPP1R1B 17q12 BRCA
Fusion : QuiverSIK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIK3 [hg38]
dbVarSIK3
ClinVarSIK3
MonarchSIK3
1000_GenomesSIK3 
Exome Variant ServerSIK3
GNOMAD BrowserENSG00000160584
Varsome BrowserSIK3
Genomic Variants (DGV)SIK3 [DGVbeta]
DECIPHERSIK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIK3 
Mutations
ICGC Data PortalSIK3 
TCGA Data PortalSIK3 
Broad Tumor PortalSIK3
OASIS PortalSIK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIK3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSIK3
Mutations and Diseases : HGMDSIK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIK3
DgiDB (Drug Gene Interaction Database)SIK3
DoCM (Curated mutations)SIK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIK3 (select a term)
intoGenSIK3
Cancer3DSIK3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614776    618162   
Orphanet
DisGeNETSIK3
MedgenSIK3
Genetic Testing Registry SIK3
NextProtQ9Y2K2 [Medical]
GENETestsSIK3
Target ValidationSIK3
Huge Navigator SIK3 [HugePedia]
ClinGenSIK3
Clinical trials, drugs, therapy
MyCancerGenomeSIK3
Protein Interactions : CTD
Pharm GKB GenePA165543631
PharosQ9Y2K2
Clinical trialSIK3
Miscellaneous
canSAR (ICR)SIK3 (select the gene name)
HarmonizomeSIK3
DataMed IndexSIK3
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSIK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:37:19 CET 2021
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