SIM2 (SIM bHLH transcription factor 2)

2007-02-01  

Identity

HGNC
LOCATION
21q22.13
LOCUSID
ALIAS
HMC13F06,HMC29C01,SIM,bHLHe15
FUSION GENES

Other Information

Locus ID:

NCBI: 6493
MIM: 600892
HGNC: 10883
Ensembl: ENSG00000159263

Variants:

dbSNP: 6493
ClinVar: 6493
TCGA: ENSG00000159263
COSMIC: SIM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159263ENST00000290399Q14190
ENSG00000159263ENST00000431229H7BZX8
ENSG00000159263ENST00000483178V9GY04

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197379602009Identification of the transcription factor single-minded homologue 2 as a potential biomarker and immunotherapy target in prostate cancer.69
147017342004Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression.45
181607082008Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2.35
168404392007Inhibition of breast cancer growth and invasion by single-minded 2s.26
289103452017Circulating mRNAs and miRNAs as candidate markers for the diagnosis and prognosis of prostate cancer.20
196682302009The HIF1alpha-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element.18
227773542013Regulation of DCIS to invasive breast cancer progression by Singleminded-2s (SIM2s).17
161298202005Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells.16
191692762009Ha-Ras transformation of MCF10A cells leads to repression of Singleminded-2s through NOTCH and C/EBPbeta.16
126769912003Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors.15

Citation

Dessen P

SIM2 (SIM bHLH transcription factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45754/sim2