Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SIN3A (SIN3 transcription regulator family member A)

Identity

Alias_namesSIN3 homolog A, transcription regulator (yeast)
SIN3 transcription regulator homolog A (yeast)
Alias_symbol (synonym)KIAA0700
DKFZP434K2235
Other aliasWITKOS
HGNC (Hugo) SIN3A
LocusID (NCBI) 25942
Atlas_Id 42298
Location 15q24.2  [Link to chromosome band 15q24]
Location_base_pair Starts at 75369379 and ends at 75455783 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AFAP1 (4p16.1) / SIN3A (15q24.2)FIS1 (7q22.1) / SIN3A (15q24.2)MAN2C1 (15q24.2) / SIN3A (15q24.2)
SIN3A (15q24.2) / ANKRD18B (9p13.3)SIN3A (15q24.2) / DHODH (16q22.2)SIN3A (15q24.2) / NEO1 (15q24.1)
SIN3A (15q24.2) / PTPN9 (15q24.2)SIN3A (15q24.2) / SGCZ (8p22)SIN3A (15q24.2) / SIN3A (15q24.2)
SIN3A (15q24.2) / ZNF577 (19q13.41)SIN3A 15q24.2 / NEO1 15q24.1SIN3A 15q24.2 / PTPN9 15q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  ins(12;8)(p13;q11q21) ETV6/LYN
t(1;12)(p36;p13) ETV6/PRDM16
t(9;13)(p12;q21) PAX5/DACH1
t(9;17)(p13;p12) PAX5/NCOR1


External links

Nomenclature
HGNC (Hugo)SIN3A   19353
Cards
Entrez_Gene (NCBI)SIN3A  25942  SIN3 transcription regulator family member A
AliasesWITKOS
GeneCards (Weizmann)SIN3A
Ensembl hg19 (Hinxton)ENSG00000169375 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169375 [Gene_View]  chr15:75369379-75455783 [Contig_View]  SIN3A [Vega]
ICGC DataPortalENSG00000169375
TCGA cBioPortalSIN3A
AceView (NCBI)SIN3A
Genatlas (Paris)SIN3A
WikiGenes25942
SOURCE (Princeton)SIN3A
Genetics Home Reference (NIH)SIN3A
Genomic and cartography
GoldenPath hg38 (UCSC)SIN3A  -     chr15:75369379-75455783 -  15q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIN3A  -     15q24.2   [Description]    (hg19-Feb_2009)
EnsemblSIN3A - 15q24.2 [CytoView hg19]  SIN3A - 15q24.2 [CytoView hg38]
Mapping of homologs : NCBISIN3A [Mapview hg19]  SIN3A [Mapview hg38]
OMIM607776   613406   
Gene and transcription
Genbank (Entrez)AF418569 AK027559 AK074800 AK074903 AK096477
RefSeq transcript (Entrez)NM_001145357 NM_001145358 NM_015477
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIN3A
Cluster EST : UnigeneHs.513039 [ NCBI ]
CGAP (NCI)Hs.513039
Alternative Splicing GalleryENSG00000169375
Gene ExpressionSIN3A [ NCBI-GEO ]   SIN3A [ EBI - ARRAY_EXPRESS ]   SIN3A [ SEEK ]   SIN3A [ MEM ]
Gene Expression Viewer (FireBrowse)SIN3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25942
GTEX Portal (Tissue expression)SIN3A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96ST3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96ST3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96ST3
Splice isoforms : SwissVarQ96ST3
PhosPhoSitePlusQ96ST3
Domaine pattern : Prosite (Expaxy)PAH (PS51477)   
Domains : Interpro (EBI)HDAC_interact_dom    PAH    Sin3_C   
Domain families : Pfam (Sanger)PAH (PF02671)    Sin3_corepress (PF08295)    Sin3a_C (PF16879)   
Domain families : Pfam (NCBI)pfam02671    pfam08295    pfam16879   
Domain families : Smart (EMBL)HDAC_interact (SM00761)  
Conserved Domain (NCBI)SIN3A
DMDM Disease mutations25942
Blocks (Seattle)SIN3A
PDB (SRS)1PO4   
PDB (PDBSum)1PO4   
PDB (IMB)1PO4   
PDB (RSDB)1PO4   
Structural Biology KnowledgeBase1PO4   
SCOP (Structural Classification of Proteins)1PO4   
CATH (Classification of proteins structures)1PO4   
SuperfamilyQ96ST3
Human Protein AtlasENSG00000169375
Peptide AtlasQ96ST3
HPRD09690
IPIIPI00170596   IPI00981448   
Protein Interaction databases
DIP (DOE-UCLA)Q96ST3
IntAct (EBI)Q96ST3
FunCoupENSG00000169375
BioGRIDSIN3A
STRING (EMBL)SIN3A
ZODIACSIN3A
Ontologies - Pathways
QuickGOQ96ST3
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  kinetochore  transcription regulatory region sequence-specific DNA binding  RNA polymerase II activating transcription factor binding  RNA polymerase II repressing transcription factor binding  RNA polymerase II transcription corepressor activity  in utero embryonic development  activation of innate immune response  positive regulation of defense response to virus by host  hematopoietic progenitor cell differentiation  chromatin binding  transcription factor activity, sequence-specific DNA binding  RNA binding  histone deacetylase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  nucleolus  DNA replication  transcription, DNA-templated  protein deacetylation  aging  regulation of hormone levels  positive regulation of G2/M transition of mitotic cell cycle  histone deacetylation  Sin3 complex  Sin3 complex  transcriptional repressor complex  positive regulation of chromatin silencing  protein complex binding  protein deacetylase activity  cellular protein localization  negative regulation of circadian rhythm  negative regulation of apoptotic process  regulation of transcription from RNA polymerase II promoter in response to oxidative stress  cellular lipid metabolic process  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  rhythmic process  response to methylglyoxal  cellular response to glucose stimulus  negative regulation of protein localization to nucleus  negative regulation of histone H3-K27 acetylation  cellular response to dopamine  negative regulation of transcription regulatory region DNA binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  kinetochore  transcription regulatory region sequence-specific DNA binding  RNA polymerase II activating transcription factor binding  RNA polymerase II repressing transcription factor binding  RNA polymerase II transcription corepressor activity  in utero embryonic development  activation of innate immune response  positive regulation of defense response to virus by host  hematopoietic progenitor cell differentiation  chromatin binding  transcription factor activity, sequence-specific DNA binding  RNA binding  histone deacetylase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  nucleolus  DNA replication  transcription, DNA-templated  protein deacetylation  aging  regulation of hormone levels  positive regulation of G2/M transition of mitotic cell cycle  histone deacetylation  Sin3 complex  Sin3 complex  transcriptional repressor complex  positive regulation of chromatin silencing  protein complex binding  protein deacetylase activity  cellular protein localization  negative regulation of circadian rhythm  negative regulation of apoptotic process  regulation of transcription from RNA polymerase II promoter in response to oxidative stress  cellular lipid metabolic process  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  rhythmic process  response to methylglyoxal  cellular response to glucose stimulus  negative regulation of protein localization to nucleus  negative regulation of histone H3-K27 acetylation  cellular response to dopamine  negative regulation of transcription regulatory region DNA binding  
Pathways : BIOCARTAMETS affect on Macrophage Differentiation [Genes]   
Pathways : KEGGThyroid hormone signaling pathway    Huntington's disease    Transcriptional misregulation in cancer   
NDEx NetworkSIN3A
Atlas of Cancer Signalling NetworkSIN3A
Wikipedia pathwaysSIN3A
Orthology - Evolution
OrthoDB25942
GeneTree (enSembl)ENSG00000169375
Phylogenetic Trees/Animal Genes : TreeFamSIN3A
HOVERGENQ96ST3
HOGENOMQ96ST3
Homologs : HomoloGeneSIN3A
Homology/Alignments : Family Browser (UCSC)SIN3A
Gene fusions - Rearrangements
Fusion : MitelmanSIN3A/NEO1 [15q24.2/15q24.1]  
Fusion : MitelmanSIN3A/PTPN9 [15q24.2/15q24.2]  [t(15;15)(q24;q24)]  
Fusion: TCGASIN3A 15q24.2 NEO1 15q24.1 BRCA
Fusion: TCGASIN3A 15q24.2 PTPN9 15q24.2 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIN3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIN3A
dbVarSIN3A
ClinVarSIN3A
1000_GenomesSIN3A 
Exome Variant ServerSIN3A
ExAC (Exome Aggregation Consortium)SIN3A (select the gene name)
Genetic variants : HAPMAP25942
Genomic Variants (DGViSIN3A [DGVbeta]
DECIPHERSIN3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIN3A 
Mutations
ICGC Data PortalSIN3A 
TCGA Data PortalSIN3A 
Broad Tumor PortalSIN3A
OASIS PortalSIN3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIN3A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIN3A
intOGen PortalSIN3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIN3A
DgiDB (Drug Gene Interaction Database)SIN3A
DoCM (Curated mutations)SIN3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIN3A (select a term)
intoGenSIN3A
Cancer3DSIN3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607776    613406   
Orphanet
MedgenSIN3A
Genetic Testing Registry SIN3A
NextProtQ96ST3 [Medical]
TSGene25942
GENETestsSIN3A
Target ValidationSIN3A
Huge Navigator SIN3A [HugePedia]
snp3D : Map Gene to Disease25942
BioCentury BCIQSIN3A
ClinGenSIN3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25942
Chemical/Pharm GKB GenePA134993567
Clinical trialSIN3A
Miscellaneous
canSAR (ICR)SIN3A (select the gene name)
Probes
Litterature
PubMed252 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIN3A
EVEXSIN3A
GoPubMedSIN3A
iHOPSIN3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:31:06 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.