SIN3B (SIN3 transcription regulator family member B)

2007-04-01  

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 23309
MIM: 607777
HGNC: 19354
Ensembl: ENSG00000127511

Variants:

dbSNP: 23309
ClinVar: 23309
TCGA: ENSG00000127511
COSMIC: SIN3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127511ENST00000248054O75182
ENSG00000127511ENST00000379803O75182
ENSG00000127511ENST00000595541M0QYC5
ENSG00000127511ENST00000596638M0R271
ENSG00000127511ENST00000596802O75182

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
161666252005Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.41
210414822011A novel mammalian complex containing Sin3B mitigates histone acetylation and RNA polymerase II progression within transcribed loci.35
196543062009Sin3B expression is required for cellular senescence and is up-regulated upon oncogenic stress.23
246914452014Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression.21
205478422010Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells.18
220288232011Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
249515942014Sin3b interacts with Myc and decreases Myc levels.10
277809282016SIN3A and SIN3B differentially regulate breast cancer metastasis.9

Citation

Dessen P

SIN3B (SIN3 transcription regulator family member B)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47238/sin3b