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SIN3B (SIN3 transcription regulator family member B)

Identity

Alias_namesSIN3 homolog B, transcription regulator (yeast)
SIN3 transcription regulator homolog B (yeast)
Alias_symbol (synonym)KIAA0700
Other alias-
HGNC (Hugo) SIN3B
LocusID (NCBI) 23309
Atlas_Id 47238
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at 16829387 and ends at 16880353 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SIN3B (19p13.11) / SIN3B (19p13.11)YEATS2 (3q27.1) / SIN3B (19p13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  ins(12;8)(p13;q11q21) ETV6/LYN
t(1;12)(p36;p13) ETV6/PRDM16
t(9;13)(p12;q21) PAX5/DACH1
t(9;17)(p13;p12) PAX5/NCOR1


External links

Nomenclature
HGNC (Hugo)SIN3B   19354
Cards
Entrez_Gene (NCBI)SIN3B  23309  SIN3 transcription regulator family member B
Aliases
GeneCards (Weizmann)SIN3B
Ensembl hg19 (Hinxton)ENSG00000127511 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127511 [Gene_View]  chr19:16829387-16880353 [Contig_View]  SIN3B [Vega]
ICGC DataPortalENSG00000127511
TCGA cBioPortalSIN3B
AceView (NCBI)SIN3B
Genatlas (Paris)SIN3B
WikiGenes23309
SOURCE (Princeton)SIN3B
Genetics Home Reference (NIH)SIN3B
Genomic and cartography
GoldenPath hg38 (UCSC)SIN3B  -     chr19:16829387-16880353 +  19p13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIN3B  -     19p13.11   [Description]    (hg19-Feb_2009)
EnsemblSIN3B - 19p13.11 [CytoView hg19]  SIN3B - 19p13.11 [CytoView hg38]
Mapping of homologs : NCBISIN3B [Mapview hg19]  SIN3B [Mapview hg38]
OMIM607777   
Gene and transcription
Genbank (Entrez)AB014600 AK001633 AK295618 AK311023 AY706204
RefSeq transcript (Entrez)NM_001297595 NM_001297597 NM_015260
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIN3B
Cluster EST : UnigeneHs.13999 [ NCBI ]
CGAP (NCI)Hs.13999
Alternative Splicing GalleryENSG00000127511
Gene ExpressionSIN3B [ NCBI-GEO ]   SIN3B [ EBI - ARRAY_EXPRESS ]   SIN3B [ SEEK ]   SIN3B [ MEM ]
Gene Expression Viewer (FireBrowse)SIN3B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23309
GTEX Portal (Tissue expression)SIN3B
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75182   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75182  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75182
Splice isoforms : SwissVarO75182
PhosPhoSitePlusO75182
Domaine pattern : Prosite (Expaxy)PAH (PS51477)   
Domains : Interpro (EBI)HDAC_interact_dom    PAH    Sin3_C   
Domain families : Pfam (Sanger)PAH (PF02671)    Sin3_corepress (PF08295)    Sin3a_C (PF16879)   
Domain families : Pfam (NCBI)pfam02671    pfam08295    pfam16879   
Domain families : Smart (EMBL)HDAC_interact (SM00761)  
Conserved Domain (NCBI)SIN3B
DMDM Disease mutations23309
Blocks (Seattle)SIN3B
SuperfamilyO75182
Human Protein AtlasENSG00000127511
Peptide AtlasO75182
HPRD09691
IPIIPI00464980   IPI00607589   IPI00607724   IPI00976382   
Protein Interaction databases
DIP (DOE-UCLA)O75182
IntAct (EBI)O75182
FunCoupENSG00000127511
BioGRIDSIN3B
STRING (EMBL)SIN3B
ZODIACSIN3B
Ontologies - Pathways
QuickGOO75182
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  X chromosome  Y chromosome  RNA polymerase II transcription corepressor activity  XY body  chromatin binding  histone deacetylase activity  protein binding  nucleus  nucleoplasm  cytoplasm  transcription, DNA-templated  histone deacetylation  Sin3 complex  autosome  cellular lipid metabolic process  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  X chromosome  Y chromosome  RNA polymerase II transcription corepressor activity  XY body  chromatin binding  histone deacetylase activity  protein binding  nucleus  nucleoplasm  cytoplasm  transcription, DNA-templated  histone deacetylation  Sin3 complex  autosome  cellular lipid metabolic process  
Pathways : BIOCARTAMETS affect on Macrophage Differentiation [Genes]   
NDEx NetworkSIN3B
Atlas of Cancer Signalling NetworkSIN3B
Wikipedia pathwaysSIN3B
Orthology - Evolution
OrthoDB23309
GeneTree (enSembl)ENSG00000127511
Phylogenetic Trees/Animal Genes : TreeFamSIN3B
HOVERGENO75182
HOGENOMO75182
Homologs : HomoloGeneSIN3B
Homology/Alignments : Family Browser (UCSC)SIN3B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIN3B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIN3B
dbVarSIN3B
ClinVarSIN3B
1000_GenomesSIN3B 
Exome Variant ServerSIN3B
ExAC (Exome Aggregation Consortium)SIN3B (select the gene name)
Genetic variants : HAPMAP23309
Genomic Variants (DGV)SIN3B [DGVbeta]
DECIPHERSIN3B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIN3B 
Mutations
ICGC Data PortalSIN3B 
TCGA Data PortalSIN3B 
Broad Tumor PortalSIN3B
OASIS PortalSIN3B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIN3B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIN3B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIN3B
DgiDB (Drug Gene Interaction Database)SIN3B
DoCM (Curated mutations)SIN3B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIN3B (select a term)
intoGenSIN3B
Cancer3DSIN3B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607777   
Orphanet
MedgenSIN3B
Genetic Testing Registry SIN3B
NextProtO75182 [Medical]
TSGene23309
GENETestsSIN3B
Target ValidationSIN3B
Huge Navigator SIN3B [HugePedia]
snp3D : Map Gene to Disease23309
BioCentury BCIQSIN3B
ClinGenSIN3B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23309
Chemical/Pharm GKB GenePA134909030
Clinical trialSIN3B
Miscellaneous
canSAR (ICR)SIN3B (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIN3B
EVEXSIN3B
GoPubMedSIN3B
iHOPSIN3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:55:32 CEST 2017

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