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SIPA1L2 (signal induced proliferation associated 1 like 2)

Identity

Alias_namessignal-induced proliferation-associated 1 like 2
Alias_symbol (synonym)KIAA1389
Other aliasSPAL2
HGNC (Hugo) SIPA1L2
LocusID (NCBI) 57568
Atlas_Id 42299
Location 1q42.2  [Link to chromosome band 1q42]
Location_base_pair Starts at 232397966 and ends at 232515608 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SIPA1L2 (1q42.2) / SIPA1L2 (1q42.2)SIPA1L2 (1q42.2) / TRIM11 (1q42.13)SIPA1L2 (1q42.2) / ZNF252P (8q24.3)
SIPA1L2 (1q42.2) / ZNF41 (Xp11.23)SIPA1L2 1q42.2 / TRIM11 1q42.13SIPA1L2 1q42.2 ZNF252

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIPA1L2   23800
Cards
Entrez_Gene (NCBI)SIPA1L2  57568  signal induced proliferation associated 1 like 2
AliasesSPAL2
GeneCards (Weizmann)SIPA1L2
Ensembl hg19 (Hinxton)ENSG00000116991 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116991 [Gene_View]  chr1:232397966-232515608 [Contig_View]  SIPA1L2 [Vega]
ICGC DataPortalENSG00000116991
TCGA cBioPortalSIPA1L2
AceView (NCBI)SIPA1L2
Genatlas (Paris)SIPA1L2
WikiGenes57568
SOURCE (Princeton)SIPA1L2
Genetics Home Reference (NIH)SIPA1L2
Genomic and cartography
GoldenPath hg38 (UCSC)SIPA1L2  -     chr1:232397966-232515608 -  1q42.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIPA1L2  -     1q42.2   [Description]    (hg19-Feb_2009)
EnsemblSIPA1L2 - 1q42.2 [CytoView hg19]  SIPA1L2 - 1q42.2 [CytoView hg38]
Mapping of homologs : NCBISIPA1L2 [Mapview hg19]  SIPA1L2 [Mapview hg38]
OMIM611609   
Gene and transcription
Genbank (Entrez)AB037810 AK022852 AK026779 AK074212 AK093191
RefSeq transcript (Entrez)NM_020808
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIPA1L2
Cluster EST : UnigeneHs.745009 [ NCBI ]
CGAP (NCI)Hs.745009
Alternative Splicing GalleryENSG00000116991
Gene ExpressionSIPA1L2 [ NCBI-GEO ]   SIPA1L2 [ EBI - ARRAY_EXPRESS ]   SIPA1L2 [ SEEK ]   SIPA1L2 [ MEM ]
Gene Expression Viewer (FireBrowse)SIPA1L2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57568
GTEX Portal (Tissue expression)SIPA1L2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2F8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2F8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2F8
Splice isoforms : SwissVarQ9P2F8
PhosPhoSitePlusQ9P2F8
Domaine pattern : Prosite (Expaxy)PDZ (PS50106)    RAPGAP (PS50085)   
Domains : Interpro (EBI)PDZ    Rap_GAP_dom    SIPA1L2    SIPA1L_C   
Domain families : Pfam (Sanger)Rap_GAP (PF02145)    SPAR_C (PF11881)   
Domain families : Pfam (NCBI)pfam02145    pfam11881   
Domain families : Smart (EMBL)PDZ (SM00228)  
Conserved Domain (NCBI)SIPA1L2
DMDM Disease mutations57568
Blocks (Seattle)SIPA1L2
SuperfamilyQ9P2F8
Human Protein AtlasENSG00000116991
Peptide AtlasQ9P2F8
HPRD15346
IPIIPI00444572   IPI00444573   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2F8
IntAct (EBI)Q9P2F8
FunCoupENSG00000116991
BioGRIDSIPA1L2
STRING (EMBL)SIPA1L2
ZODIACSIPA1L2
Ontologies - Pathways
QuickGOQ9P2F8
Ontology : AmiGOGTPase activator activity  cellular_component  biological_process  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIGTPase activator activity  cellular_component  biological_process  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
Pathways : KEGGRap1 signaling pathway   
NDEx NetworkSIPA1L2
Atlas of Cancer Signalling NetworkSIPA1L2
Wikipedia pathwaysSIPA1L2
Orthology - Evolution
OrthoDB57568
GeneTree (enSembl)ENSG00000116991
Phylogenetic Trees/Animal Genes : TreeFamSIPA1L2
HOVERGENQ9P2F8
HOGENOMQ9P2F8
Homologs : HomoloGeneSIPA1L2
Homology/Alignments : Family Browser (UCSC)SIPA1L2
Gene fusions - Rearrangements
Fusion : MitelmanSIPA1L2/TRIM11 [1q42.2/1q42.13]  
Fusion : MitelmanSIPA1L2/ZNF252P [1q42.2/8q24.3]  [t(1;8)(q42;q24)]  
Fusion: TCGASIPA1L2 1q42.2 TRIM11 1q42.13 PRAD
Fusion: TCGASIPA1L2 1q42.2 ZNF252 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIPA1L2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIPA1L2
dbVarSIPA1L2
ClinVarSIPA1L2
1000_GenomesSIPA1L2 
Exome Variant ServerSIPA1L2
ExAC (Exome Aggregation Consortium)SIPA1L2 (select the gene name)
Genetic variants : HAPMAP57568
Genomic Variants (DGV)SIPA1L2 [DGVbeta]
DECIPHERSIPA1L2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIPA1L2 
Mutations
ICGC Data PortalSIPA1L2 
TCGA Data PortalSIPA1L2 
Broad Tumor PortalSIPA1L2
OASIS PortalSIPA1L2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIPA1L2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIPA1L2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIPA1L2
DgiDB (Drug Gene Interaction Database)SIPA1L2
DoCM (Curated mutations)SIPA1L2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIPA1L2 (select a term)
intoGenSIPA1L2
Cancer3DSIPA1L2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611609   
Orphanet
MedgenSIPA1L2
Genetic Testing Registry SIPA1L2
NextProtQ9P2F8 [Medical]
TSGene57568
GENETestsSIPA1L2
Target ValidationSIPA1L2
Huge Navigator SIPA1L2 [HugePedia]
snp3D : Map Gene to Disease57568
BioCentury BCIQSIPA1L2
ClinGenSIPA1L2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57568
Chemical/Pharm GKB GenePA134933243
Clinical trialSIPA1L2
Miscellaneous
canSAR (ICR)SIPA1L2 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIPA1L2
EVEXSIPA1L2
GoPubMedSIPA1L2
iHOPSIPA1L2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:55:33 CEST 2017

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