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SIPA1L2 (signal induced proliferation associated 1 like 2)

Identity

Alias (NCBI)SPAL2
SPAR2
HGNC (Hugo) SIPA1L2
HGNC Alias symbKIAA1389
SPAR2
HGNC Alias namespineā€associated RapGAP 2
HGNC Previous namesignal-induced proliferation-associated 1 like 2
LocusID (NCBI) 57568
Atlas_Id 42299
Location 1q42.2  [Link to chromosome band 1q42]
Location_base_pair Starts at 232397966 and ends at 232630133 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SIPA1L2 (1q42.2) / SIPA1L2 (1q42.2)SIPA1L2 (1q42.2) / TRIM11 (1q42.13)SIPA1L2 (1q42.2) / ZNF252P (8q24.3)
SIPA1L2 (1q42.2) / ZNF41 (Xp11.23)SIPA1L2 1q42.2 / TRIM11 1q42.13SIPA1L2 1q42.2 ZNF252

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SIPA1L2   23800
Cards
Entrez_Gene (NCBI)SIPA1L2    signal induced proliferation associated 1 like 2
AliasesSPAL2; SPAR2
GeneCards (Weizmann)SIPA1L2
Ensembl hg19 (Hinxton)ENSG00000116991 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116991 [Gene_View]  ENSG00000116991 [Sequence]  chr1:232397966-232630133 [Contig_View]  SIPA1L2 [Vega]
ICGC DataPortalENSG00000116991
TCGA cBioPortalSIPA1L2
AceView (NCBI)SIPA1L2
Genatlas (Paris)SIPA1L2
SOURCE (Princeton)SIPA1L2
Genetics Home Reference (NIH)SIPA1L2
Genomic and cartography
GoldenPath hg38 (UCSC)SIPA1L2  -     chr1:232397966-232630133 -  1q42.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIPA1L2  -     1q42.2   [Description]    (hg19-Feb_2009)
GoldenPathSIPA1L2 - 1q42.2 [CytoView hg19]  SIPA1L2 - 1q42.2 [CytoView hg38]
ImmunoBaseENSG00000116991
Genome Data Viewer NCBISIPA1L2 [Mapview hg19]  
OMIM611609   
Gene and transcription
Genbank (Entrez)AB037810 AK022852 AK026779 AK074212 AK093191
RefSeq transcript (Entrez)NM_001377488 NM_020808
Consensus coding sequences : CCDS (NCBI)SIPA1L2
Gene ExpressionSIPA1L2 [ NCBI-GEO ]   SIPA1L2 [ EBI - ARRAY_EXPRESS ]   SIPA1L2 [ SEEK ]   SIPA1L2 [ MEM ]
Gene Expression Viewer (FireBrowse)SIPA1L2 [ Firebrowse - Broad ]
GenevisibleExpression of SIPA1L2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57568
GTEX Portal (Tissue expression)SIPA1L2
Human Protein AtlasENSG00000116991-SIPA1L2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2F8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2F8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2F8
PhosPhoSitePlusQ9P2F8
Domaine pattern : Prosite (Expaxy)PDZ (PS50106)    RAPGAP (PS50085)   
Domains : Interpro (EBI)PDZ    PDZ_sf    Rap/Ran-GAP_sf    Rap_GAP_dom    SIPA1L2    SIPA1L_C   
Domain families : Pfam (Sanger)PDZ (PF00595)    Rap_GAP (PF02145)    SPAR_C (PF11881)   
Domain families : Pfam (NCBI)pfam00595    pfam02145    pfam11881   
Domain families : Smart (EMBL)PDZ (SM00228)  
Conserved Domain (NCBI)SIPA1L2
SuperfamilyQ9P2F8
AlphaFold pdb e-kbQ9P2F8   
Human Protein Atlas [tissue]ENSG00000116991-SIPA1L2 [tissue]
HPRD15346
Protein Interaction databases
DIP (DOE-UCLA)Q9P2F8
IntAct (EBI)Q9P2F8
BioGRIDSIPA1L2
STRING (EMBL)SIPA1L2
ZODIACSIPA1L2
Ontologies - Pathways
QuickGOQ9P2F8
Ontology : AmiGOGTPase activator activity  cellular_component  cytoplasm  biological_process  regulation of small GTPase mediated signal transduction  activation of GTPase activity  
Ontology : EGO-EBIGTPase activator activity  cellular_component  cytoplasm  biological_process  regulation of small GTPase mediated signal transduction  activation of GTPase activity  
Pathways : KEGGRap1 signaling pathway   
NDEx NetworkSIPA1L2
Atlas of Cancer Signalling NetworkSIPA1L2
Wikipedia pathwaysSIPA1L2
Orthology - Evolution
OrthoDB57568
GeneTree (enSembl)ENSG00000116991
Phylogenetic Trees/Animal Genes : TreeFamSIPA1L2
Homologs : HomoloGeneSIPA1L2
Homology/Alignments : Family Browser (UCSC)SIPA1L2
Gene fusions - Rearrangements
Fusion : MitelmanSIPA1L2/TRIM11 [1q42.2/1q42.13]  
Fusion : MitelmanSIPA1L2/ZNF252P [1q42.2/8q24.3]  
Fusion : QuiverSIPA1L2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIPA1L2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIPA1L2
dbVarSIPA1L2
ClinVarSIPA1L2
MonarchSIPA1L2
1000_GenomesSIPA1L2 
Exome Variant ServerSIPA1L2
GNOMAD BrowserENSG00000116991
Varsome BrowserSIPA1L2
ACMGSIPA1L2 variants
VarityQ9P2F8
Genomic Variants (DGV)SIPA1L2 [DGVbeta]
DECIPHERSIPA1L2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIPA1L2 
Mutations
ICGC Data PortalSIPA1L2 
TCGA Data PortalSIPA1L2 
Broad Tumor PortalSIPA1L2
OASIS PortalSIPA1L2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIPA1L2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSIPA1L2
Mutations and Diseases : HGMDSIPA1L2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSIPA1L2
DgiDB (Drug Gene Interaction Database)SIPA1L2
DoCM (Curated mutations)SIPA1L2
CIViC (Clinical Interpretations of Variants in Cancer)SIPA1L2
Cancer3DSIPA1L2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611609   
Orphanet
DisGeNETSIPA1L2
MedgenSIPA1L2
Genetic Testing Registry SIPA1L2
NextProtQ9P2F8 [Medical]
GENETestsSIPA1L2
Target ValidationSIPA1L2
Huge Navigator SIPA1L2 [HugePedia]
ClinGenSIPA1L2
Clinical trials, drugs, therapy
MyCancerGenomeSIPA1L2
Protein Interactions : CTDSIPA1L2
Pharm GKB GenePA134933243
PharosQ9P2F8
Clinical trialSIPA1L2
Miscellaneous
canSAR (ICR)SIPA1L2
HarmonizomeSIPA1L2
DataMed IndexSIPA1L2
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSIPA1L2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:31:13 CEST 2021

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