Identity
HGNC
LOCATION
20p13
LOCUSID
ALIAS
BIT,CD172A,MFR,MYD-1,P84,PTPNS1,SHPS1,SIRP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 140885
MIM: 602461
HGNC: 9662
Ensembl: ENSG00000198053
Variants:
dbSNP: 140885
ClinVar: 140885
TCGA: ENSG00000198053
COSMIC: SIRPA
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000198053 | ENST00000356025 | P78324 |
| ENSG00000198053 | ENST00000358771 | P78324 |
| ENSG00000198053 | ENST00000400068 | P78324 |
| ENSG00000198053 | ENST00000622179 | P78324 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38245585 | 2024 | Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα. | 1 |
| 38245585 | 2024 | Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα. | 1 |
| 35737088 | 2023 | Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma. | 2 |
| 36641515 | 2023 | Clinical Significance of Signal Regulatory Protein Alpha (SIRPα) Expression in Hepatocellular Carcinoma. | 0 |
| 36791324 | 2023 | Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata. | 3 |
| 37660478 | 2023 | A mAb to SIRPα downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia. | 0 |
| 37844448 | 2023 | SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer. | 0 |
| 38279488 | 2023 | Anti-tumor effect of PTEN and its effect on inhibition of the bone tumor through the CD47-SIRPα signaling pathway. | 0 |
| 35737088 | 2023 | Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma. | 2 |
| 36641515 | 2023 | Clinical Significance of Signal Regulatory Protein Alpha (SIRPα) Expression in Hepatocellular Carcinoma. | 0 |
| 36791324 | 2023 | Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata. | 3 |
| 37660478 | 2023 | A mAb to SIRPα downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia. | 0 |
| 37844448 | 2023 | SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer. | 0 |
| 38279488 | 2023 | Anti-tumor effect of PTEN and its effect on inhibition of the bone tumor through the CD47-SIRPα signaling pathway. | 0 |
| 34940829 | 2022 | Loss of myeloid cell-specific SIRPα, but not CD47, attenuates inflammation and suppresses atherosclerosis. | 13 |
Citation
Dessen P
SIRPA (signal regulatory protein alpha)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45658/sirpa
