SIRPA (signal regulatory protein alpha)

2007-02-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
BIT,CD172A,MFR,MYD-1,P84,PTPNS1,SHPS1,SIRP
FUSION GENES

Other Information

Locus ID:

NCBI: 140885
MIM: 602461
HGNC: 9662
Ensembl: ENSG00000198053

Variants:

dbSNP: 140885
ClinVar: 140885
TCGA: ENSG00000198053
COSMIC: SIRPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198053ENST00000356025P78324
ENSG00000198053ENST00000358771P78324
ENSG00000198053ENST00000400068P78324
ENSG00000198053ENST00000622179P78324

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Cell-Cell communicationREACTOMER-HSA-1500931
Signal regulatory protein (SIRP) family interactionsREACTOMER-HSA-391160
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
224519132012The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.352
173603802007Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages.100
217885092011Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.78
217885042011Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo.63
117926972002Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration.60
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
162915972006Species- and cell type-specific interactions between CD47 and human SIRPalpha.54
202992532010Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels.49
179545682007LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages.48
261162712015Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 "Don't Eat Me" Signals.40

Citation

Dessen P

SIRPA (signal regulatory protein alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45658/sirpa