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SIRPA (signal regulatory protein alpha)

Identity

Alias_namesPTPNS1
protein tyrosine phosphatase, non-receptor type substrate 1
signal-regulatory protein alpha
Alias_symbol (synonym)SHPS1
SIRP
MYD-1
BIT
P84
SHPS-1
SIRPalpha
CD172a
SIRPalpha2
MFR
SIRP-ALPHA-1
Other aliasCD172A
HGNC (Hugo) SIRPA
LocusID (NCBI) 140885
Atlas_Id 45658
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 1874813 and ends at 1920540 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SIRPA (20p13) / HNRNPUL2 (11q12.3)USP11 (Xp11.23) / SIRPA (20p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIRPA   9662
Cards
Entrez_Gene (NCBI)SIRPA  140885  signal regulatory protein alpha
AliasesBIT; CD172A; MFR; MYD-1; 
P84; PTPNS1; SHPS1; SIRP
GeneCards (Weizmann)SIRPA
Ensembl hg19 (Hinxton)ENSG00000198053 [Gene_View]  chr20:1874813-1920540 [Contig_View]  SIRPA [Vega]
Ensembl hg38 (Hinxton)ENSG00000198053 [Gene_View]  chr20:1874813-1920540 [Contig_View]  SIRPA [Vega]
ICGC DataPortalENSG00000198053
TCGA cBioPortalSIRPA
AceView (NCBI)SIRPA
Genatlas (Paris)SIRPA
WikiGenes140885
SOURCE (Princeton)SIRPA
Genetics Home Reference (NIH)SIRPA
Genomic and cartography
GoldenPath hg19 (UCSC)SIRPA  -     chr20:1874813-1920540 +  20p13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SIRPA  -     20p13   [Description]    (hg38-Dec_2013)
EnsemblSIRPA - 20p13 [CytoView hg19]  SIRPA - 20p13 [CytoView hg38]
Mapping of homologs : NCBISIRPA [Mapview hg19]  SIRPA [Mapview hg38]
OMIM602461   
Gene and transcription
Genbank (Entrez)AB023430 AK290776 AK298243 AK312521 BC026692
RefSeq transcript (Entrez)NM_001040022 NM_001040023 NM_080792
RefSeq genomic (Entrez)NC_000020 NC_018931 NT_011387 NW_004929416
Consensus coding sequences : CCDS (NCBI)SIRPA
Cluster EST : UnigeneHs.581021 [ NCBI ]
CGAP (NCI)Hs.581021
Alternative Splicing GalleryENSG00000198053
Gene ExpressionSIRPA [ NCBI-GEO ]   SIRPA [ EBI - ARRAY_EXPRESS ]   SIRPA [ SEEK ]   SIRPA [ MEM ]
Gene Expression Viewer (FireBrowse)SIRPA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)140885
GTEX Portal (Tissue expression)SIRPA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78324   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78324  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78324
Splice isoforms : SwissVarP78324
PhosPhoSitePlusP78324
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_C1-set    Ig_sub    Ig_V-set   
Domain families : Pfam (Sanger)C1-set (PF07654)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07654    pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGc1 (SM00407)  
Conserved Domain (NCBI)SIRPA
DMDM Disease mutations140885
Blocks (Seattle)SIRPA
PDB (SRS)2JJS    2JJT    2UV3    2WNG    4CMM   
PDB (PDBSum)2JJS    2JJT    2UV3    2WNG    4CMM   
PDB (IMB)2JJS    2JJT    2UV3    2WNG    4CMM   
PDB (RSDB)2JJS    2JJT    2UV3    2WNG    4CMM   
Structural Biology KnowledgeBase2JJS    2JJT    2UV3    2WNG    4CMM   
SCOP (Structural Classification of Proteins)2JJS    2JJT    2UV3    2WNG    4CMM   
CATH (Classification of proteins structures)2JJS    2JJT    2UV3    2WNG    4CMM   
SuperfamilyP78324
Human Protein AtlasENSG00000198053
Peptide AtlasP78324
HPRD03912
IPIIPI00656087   IPI00848309   IPI01008905   IPI00232311   IPI00976836   
Protein Interaction databases
DIP (DOE-UCLA)P78324
IntAct (EBI)P78324
FunCoupENSG00000198053
BioGRIDSIRPA
STRING (EMBL)SIRPA
ZODIACSIRPA
Ontologies - Pathways
QuickGOP78324
Ontology : AmiGOplasma membrane  cell adhesion  membrane  integral component of membrane  SH3 domain binding  leukocyte migration  extracellular exosome  
Ontology : EGO-EBIplasma membrane  cell adhesion  membrane  integral component of membrane  SH3 domain binding  leukocyte migration  extracellular exosome  
Pathways : KEGGOsteoclast differentiation   
NDEx NetworkSIRPA
Atlas of Cancer Signalling NetworkSIRPA
Wikipedia pathwaysSIRPA
Orthology - Evolution
OrthoDB140885
GeneTree (enSembl)ENSG00000198053
Phylogenetic Trees/Animal Genes : TreeFamSIRPA
HOVERGENP78324
HOGENOMP78324
Homologs : HomoloGeneSIRPA
Homology/Alignments : Family Browser (UCSC)SIRPA
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIRPA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIRPA
dbVarSIRPA
ClinVarSIRPA
1000_GenomesSIRPA 
Exome Variant ServerSIRPA
ExAC (Exome Aggregation Consortium)SIRPA (select the gene name)
Genetic variants : HAPMAP140885
Genomic Variants (DGV)SIRPA [DGVbeta]
DECIPHER (Syndromes)20:1874813-1920540  ENSG00000198053
CONAN: Copy Number AnalysisSIRPA 
Mutations
ICGC Data PortalSIRPA 
TCGA Data PortalSIRPA 
Broad Tumor PortalSIRPA
OASIS PortalSIRPA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIRPA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIRPA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIRPA
DgiDB (Drug Gene Interaction Database)SIRPA
DoCM (Curated mutations)SIRPA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIRPA (select a term)
intoGenSIRPA
Cancer3DSIRPA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602461   
Orphanet
MedgenSIRPA
Genetic Testing Registry SIRPA
NextProtP78324 [Medical]
TSGene140885
GENETestsSIRPA
Huge Navigator SIRPA [HugePedia]
snp3D : Map Gene to Disease140885
BioCentury BCIQSIRPA
ClinGenSIRPA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD140885
Chemical/Pharm GKB GenePA34006
Clinical trialSIRPA
Miscellaneous
canSAR (ICR)SIRPA (select the gene name)
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIRPA
EVEXSIRPA
GoPubMedSIRPA
iHOPSIRPA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:27:20 CET 2017

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