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SIRPA (signal regulatory protein alpha)

Identity

Alias_namesPTPNS1
protein tyrosine phosphatase, non-receptor type substrate 1
signal-regulatory protein alpha
Alias_symbol (synonym)SHPS1
SIRP
MYD-1
BIT
P84
SHPS-1
SIRPalpha
CD172a
SIRPalpha2
MFR
SIRP-ALPHA-1
Other aliasCD172A
HGNC (Hugo) SIRPA
LocusID (NCBI) 140885
Atlas_Id 45658
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 1894779 and ends at 1939894 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SIRPA (20p13) / HNRNPUL2 (11q12.3)USP11 (Xp11.23) / SIRPA (20p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIRPA   9662
Cards
Entrez_Gene (NCBI)SIRPA  140885  signal regulatory protein alpha
AliasesBIT; CD172A; MFR; MYD-1; 
P84; PTPNS1; SHPS1; SIRP
GeneCards (Weizmann)SIRPA
Ensembl hg19 (Hinxton)ENSG00000198053 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198053 [Gene_View]  ENSG00000198053 [Sequence]  chr20:1894779-1939894 [Contig_View]  SIRPA [Vega]
ICGC DataPortalENSG00000198053
TCGA cBioPortalSIRPA
AceView (NCBI)SIRPA
Genatlas (Paris)SIRPA
WikiGenes140885
SOURCE (Princeton)SIRPA
Genetics Home Reference (NIH)SIRPA
Genomic and cartography
GoldenPath hg38 (UCSC)SIRPA  -     chr20:1894779-1939894 +  20p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIRPA  -     20p13   [Description]    (hg19-Feb_2009)
EnsemblSIRPA - 20p13 [CytoView hg19]  SIRPA - 20p13 [CytoView hg38]
Mapping of homologs : NCBISIRPA [Mapview hg19]  SIRPA [Mapview hg38]
OMIM602461   
Gene and transcription
Genbank (Entrez)AB023430 AK290776 AK298243 AK312521 BC026692
RefSeq transcript (Entrez)NM_001040022 NM_001040023 NM_001330728 NM_080792
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIRPA
Cluster EST : UnigeneHs.581021 [ NCBI ]
CGAP (NCI)Hs.581021
Alternative Splicing GalleryENSG00000198053
Gene ExpressionSIRPA [ NCBI-GEO ]   SIRPA [ EBI - ARRAY_EXPRESS ]   SIRPA [ SEEK ]   SIRPA [ MEM ]
Gene Expression Viewer (FireBrowse)SIRPA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)140885
GTEX Portal (Tissue expression)SIRPA
Human Protein AtlasENSG00000198053-SIRPA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78324   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78324  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78324
Splice isoforms : SwissVarP78324
PhosPhoSitePlusP78324
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_C1-set    Ig_sub    Ig_V-set   
Domain families : Pfam (Sanger)C1-set (PF07654)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07654    pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGc1 (SM00407)  IGv (SM00406)  
Conserved Domain (NCBI)SIRPA
DMDM Disease mutations140885
Blocks (Seattle)SIRPA
PDB (SRS)2JJS    2JJT    2UV3    2WNG    4CMM    6BIT   
PDB (PDBSum)2JJS    2JJT    2UV3    2WNG    4CMM    6BIT   
PDB (IMB)2JJS    2JJT    2UV3    2WNG    4CMM    6BIT   
PDB (RSDB)2JJS    2JJT    2UV3    2WNG    4CMM    6BIT   
Structural Biology KnowledgeBase2JJS    2JJT    2UV3    2WNG    4CMM    6BIT   
SCOP (Structural Classification of Proteins)2JJS    2JJT    2UV3    2WNG    4CMM    6BIT   
CATH (Classification of proteins structures)2JJS    2JJT    2UV3    2WNG    4CMM    6BIT   
SuperfamilyP78324
Human Protein Atlas [tissue]ENSG00000198053-SIRPA [tissue]
Peptide AtlasP78324
HPRD03912
IPIIPI00656087   IPI00848309   IPI01008905   IPI00232311   IPI00976836   
Protein Interaction databases
DIP (DOE-UCLA)P78324
IntAct (EBI)P78324
FunCoupENSG00000198053
BioGRIDSIRPA
STRING (EMBL)SIRPA
ZODIACSIRPA
Ontologies - Pathways
QuickGOP78324
Ontology : AmiGOnegative regulation of protein phosphorylation  plasma membrane  plasma membrane  integral component of plasma membrane  cell adhesion  cell surface  cell surface  cell surface  regulation of gene expression  membrane  cell migration  SH3 domain binding  protein phosphatase binding  positive regulation of cell-cell adhesion  GTPase regulator activity  regulation of interferon-gamma production  regulation of interleukin-1 beta production  regulation of interleukin-6 production  regulation of tumor necrosis factor production  regulation of tumor necrosis factor production  negative regulation of interferon-beta production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  heterotypic cell-cell adhesion  monocyte extravasation  neutrophil degranulation  negative regulation of nitric oxide biosynthetic process  regulation of nitric oxide biosynthetic process  negative regulation of JNK cascade  negative regulation of inflammatory response  negative regulation of phagocytosis  positive regulation of phagocytosis  regulation of catalytic activity  positive regulation of T cell activation  leukocyte migration  extracellular exosome  cellular response to hydrogen peroxide  negative regulation of ERK1 and ERK2 cascade  tertiary granule membrane  cellular response to lipopolysaccharide  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to interleukin-12  negative regulation of macrophage inflammatory protein 1 alpha production  negative regulation of chemokine (C-C motif) ligand 5 production  protein binding involved in heterotypic cell-cell adhesion  cell-cell adhesion mediator activity  ficolin-1-rich granule membrane  negative regulation of cytokine production involved in inflammatory response  negative regulation of I-kappaB phosphorylation  protein antigen binding  protein tyrosine kinase binding  
Ontology : EGO-EBInegative regulation of protein phosphorylation  plasma membrane  plasma membrane  integral component of plasma membrane  cell adhesion  cell surface  cell surface  cell surface  regulation of gene expression  membrane  cell migration  SH3 domain binding  protein phosphatase binding  positive regulation of cell-cell adhesion  GTPase regulator activity  regulation of interferon-gamma production  regulation of interleukin-1 beta production  regulation of interleukin-6 production  regulation of tumor necrosis factor production  regulation of tumor necrosis factor production  negative regulation of interferon-beta production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  heterotypic cell-cell adhesion  monocyte extravasation  neutrophil degranulation  negative regulation of nitric oxide biosynthetic process  regulation of nitric oxide biosynthetic process  negative regulation of JNK cascade  negative regulation of inflammatory response  negative regulation of phagocytosis  positive regulation of phagocytosis  regulation of catalytic activity  positive regulation of T cell activation  leukocyte migration  extracellular exosome  cellular response to hydrogen peroxide  negative regulation of ERK1 and ERK2 cascade  tertiary granule membrane  cellular response to lipopolysaccharide  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to interleukin-12  negative regulation of macrophage inflammatory protein 1 alpha production  negative regulation of chemokine (C-C motif) ligand 5 production  protein binding involved in heterotypic cell-cell adhesion  cell-cell adhesion mediator activity  ficolin-1-rich granule membrane  negative regulation of cytokine production involved in inflammatory response  negative regulation of I-kappaB phosphorylation  protein antigen binding  protein tyrosine kinase binding  
Pathways : KEGGOsteoclast differentiation   
NDEx NetworkSIRPA
Atlas of Cancer Signalling NetworkSIRPA
Wikipedia pathwaysSIRPA
Orthology - Evolution
OrthoDB140885
GeneTree (enSembl)ENSG00000198053
Phylogenetic Trees/Animal Genes : TreeFamSIRPA
HOVERGENP78324
HOGENOMP78324
Homologs : HomoloGeneSIRPA
Homology/Alignments : Family Browser (UCSC)SIRPA
Gene fusions - Rearrangements
Fusion : QuiverSIRPA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIRPA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIRPA
dbVarSIRPA
ClinVarSIRPA
1000_GenomesSIRPA 
Exome Variant ServerSIRPA
ExAC (Exome Aggregation Consortium)ENSG00000198053
GNOMAD BrowserENSG00000198053
Varsome BrowserSIRPA
Genetic variants : HAPMAP140885
Genomic Variants (DGV)SIRPA [DGVbeta]
DECIPHERSIRPA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIRPA 
Mutations
ICGC Data PortalSIRPA 
TCGA Data PortalSIRPA 
Broad Tumor PortalSIRPA
OASIS PortalSIRPA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIRPA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIRPA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIRPA
DgiDB (Drug Gene Interaction Database)SIRPA
DoCM (Curated mutations)SIRPA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIRPA (select a term)
intoGenSIRPA
Cancer3DSIRPA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602461   
Orphanet
DisGeNETSIRPA
MedgenSIRPA
Genetic Testing Registry SIRPA
NextProtP78324 [Medical]
TSGene140885
GENETestsSIRPA
Target ValidationSIRPA
Huge Navigator SIRPA [HugePedia]
snp3D : Map Gene to Disease140885
BioCentury BCIQSIRPA
ClinGenSIRPA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD140885
Chemical/Pharm GKB GenePA34006
Clinical trialSIRPA
Miscellaneous
canSAR (ICR)SIRPA (select the gene name)
Probes
Litterature
PubMed115 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIRPA
EVEXSIRPA
GoPubMedSIRPA
iHOPSIRPA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:39:09 CET 2018

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