SIRPG (signal regulatory protein gamma)

2009-10-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
CD172g,SIRP-B2,SIRPB2,SIRPgamma,bA77C3.1

Other Information

Locus ID:

NCBI: 55423
MIM: 605466
HGNC: 15757
Ensembl: ENSG00000089012

Variants:

dbSNP: 55423
ClinVar: 55423
TCGA: ENSG00000089012
COSMIC: SIRPG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089012ENST00000216927Q9P1W8
ENSG00000089012ENST00000303415Q9P1W8
ENSG00000089012ENST00000344103Q9P1W8
ENSG00000089012ENST00000381580Q9P1W8
ENSG00000089012ENST00000381583Q9P1W8

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Cell-Cell communicationREACTOMER-HSA-1500931
Signal regulatory protein (SIRP) family interactionsREACTOMER-HSA-391160

References

Pubmed IDYearTitleCitations
152949722004Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family.34
185249902008Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro.29
194735662009Changes in the gene expression of peripheral blood mononuclear cells during the menstrual cycle of females is associated with a gender bias in the incidence of systemic lupus erythematosus.5
241629482014Pathogenic variants screening in five non-obstructive azoospermia-associated genes.5
238267702013Crystal structure of signal regulatory protein gamma (SIRPγ) in complex with an antibody Fab fragment.1
303376752018An autoimmune disease risk SNP, rs2281808, in SIRPG is associated with reduced expression of SIRPγ and heightened effector state in human CD8 T-cells.1

Citation

Dessen P

SIRPG (signal regulatory protein gamma)

Atlas Genet Cytogenet Oncol Haematol. 2009-10-01

Online version: http://atlasgeneticsoncology.org/gene/51138/sirpg