SIRT3 (sirtuin 3)

2010-03-01  

Identity

HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
SIR2L3
FUSION GENES

Other Information

Locus ID:

NCBI: 23410
MIM: 604481
HGNC: 14931
Ensembl: ENSG00000142082

Variants:

dbSNP: 23410
ClinVar: 23410
TCGA: ENSG00000142082
COSMIC: SIRT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142082ENST00000382743Q9NTG7
ENSG00000142082ENST00000524564E9PN58
ENSG00000142082ENST00000525237E9PR48
ENSG00000142082ENST00000525319E9PK80
ENSG00000142082ENST00000525776E9PM52
ENSG00000142082ENST00000526854E9PJS6
ENSG00000142082ENST00000528469E9PNA0
ENSG00000142082ENST00000529055E9PIT6
ENSG00000142082ENST00000529382Q9NTG7
ENSG00000142082ENST00000529937B7WNN4
ENSG00000142082ENST00000530067E9PIT6
ENSG00000142082ENST00000532837E9PIT6
ENSG00000142082ENST00000532956E9PM75

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
201292462010SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress.298
213978632011SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization.281
121868502002The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase.227
206614742010Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis.214
187109442008SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.200
215666442011Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS.192
186807532008Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.191
123748522002SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria.179
213586712011SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production.158
174379972007SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress.144

Citation

Dessen P

SIRT3 (sirtuin 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51385/sirt3