Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SIRT3 (sirtuin 3)

Identity

Alias_namessirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3
sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)
Alias_symbol (synonym)SIR2L3
Other alias
HGNC (Hugo) SIRT3
LocusID (NCBI) 23410
Atlas_Id 51385
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 215030 and ends at 236362 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP2B4 (1q32.1) / SIRT3 (11p15.5)CCPG1 (15q21.3) / SIRT3 (11p15.5)SIRT3 (11p15.5) / MED25 (19q13.33)
SPON1 (11p15.2) / SIRT3 (11p15.5)SPON1 11p15.2 / SIRT3 11p15.5

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  SPON1/SIRT3 (11p15)

External links

Nomenclature
HGNC (Hugo)SIRT3   14931
Cards
Entrez_Gene (NCBI)SIRT3  23410  sirtuin 3
AliasesSIR2L3
GeneCards (Weizmann)SIRT3
Ensembl hg19 (Hinxton)ENSG00000142082 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142082 [Gene_View]  ENSG00000142082 [Sequence]  chr11:215030-236362 [Contig_View]  SIRT3 [Vega]
ICGC DataPortalENSG00000142082
TCGA cBioPortalSIRT3
AceView (NCBI)SIRT3
Genatlas (Paris)SIRT3
WikiGenes23410
SOURCE (Princeton)SIRT3
Genetics Home Reference (NIH)SIRT3
Genomic and cartography
GoldenPath hg38 (UCSC)SIRT3  -     chr11:215030-236362 -  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIRT3  -     11p15.5   [Description]    (hg19-Feb_2009)
EnsemblSIRT3 - 11p15.5 [CytoView hg19]  SIRT3 - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBISIRT3 [Mapview hg19]  SIRT3 [Mapview hg38]
OMIM604481   
Gene and transcription
Genbank (Entrez)AA279020 AF083108 AI091200 AK074992 AK298572
RefSeq transcript (Entrez)NM_001017524 NM_012239
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIRT3
Cluster EST : UnigeneHs.716456 [ NCBI ]
CGAP (NCI)Hs.716456
Alternative Splicing GalleryENSG00000142082
Gene ExpressionSIRT3 [ NCBI-GEO ]   SIRT3 [ EBI - ARRAY_EXPRESS ]   SIRT3 [ SEEK ]   SIRT3 [ MEM ]
Gene Expression Viewer (FireBrowse)SIRT3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23410
GTEX Portal (Tissue expression)SIRT3
Human Protein AtlasENSG00000142082-SIRT3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NTG7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NTG7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NTG7
Splice isoforms : SwissVarQ9NTG7
Catalytic activity : Enzyme3.5.1.- [ Enzyme-Expasy ]   3.5.1.-3.5.1.- [ IntEnz-EBI ]   3.5.1.- [ BRENDA ]   3.5.1.- [ KEGG ]   
PhosPhoSitePlusQ9NTG7
Domaine pattern : Prosite (Expaxy)SIRTUIN (PS50305)   
Domains : Interpro (EBI)DHS-like_NAD/FAD-binding_dom    Sirtuin    Sirtuin_cat_small_dom_sf    Sirtuin_class_I    Ssirtuin_cat_dom   
Domain families : Pfam (Sanger)SIR2 (PF02146)   
Domain families : Pfam (NCBI)pfam02146   
Conserved Domain (NCBI)SIRT3
DMDM Disease mutations23410
Blocks (Seattle)SIRT3
PDB (SRS)3GLR    3GLS    3GLT    3GLU    4BN4    4BN5    4BV3    4BVB    4BVE    4BVF    4BVG    4BVH    4C78    4C7B    4FVT    4FZ3    4HD8    4JSR    4JT8    4JT9    4O8Z    4V1C    5BWN    5BWO    5D7N    5H4D    5YTK   
PDB (PDBSum)3GLR    3GLS    3GLT    3GLU    4BN4    4BN5    4BV3    4BVB    4BVE    4BVF    4BVG    4BVH    4C78    4C7B    4FVT    4FZ3    4HD8    4JSR    4JT8    4JT9    4O8Z    4V1C    5BWN    5BWO    5D7N    5H4D    5YTK   
PDB (IMB)3GLR    3GLS    3GLT    3GLU    4BN4    4BN5    4BV3    4BVB    4BVE    4BVF    4BVG    4BVH    4C78    4C7B    4FVT    4FZ3    4HD8    4JSR    4JT8    4JT9    4O8Z    4V1C    5BWN    5BWO    5D7N    5H4D    5YTK   
PDB (RSDB)3GLR    3GLS    3GLT    3GLU    4BN4    4BN5    4BV3    4BVB    4BVE    4BVF    4BVG    4BVH    4C78    4C7B    4FVT    4FZ3    4HD8    4JSR    4JT8    4JT9    4O8Z    4V1C    5BWN    5BWO    5D7N    5H4D    5YTK   
Structural Biology KnowledgeBase3GLR    3GLS    3GLT    3GLU    4BN4    4BN5    4BV3    4BVB    4BVE    4BVF    4BVG    4BVH    4C78    4C7B    4FVT    4FZ3    4HD8    4JSR    4JT8    4JT9    4O8Z    4V1C    5BWN    5BWO    5D7N    5H4D    5YTK   
SCOP (Structural Classification of Proteins)3GLR    3GLS    3GLT    3GLU    4BN4    4BN5    4BV3    4BVB    4BVE    4BVF    4BVG    4BVH    4C78    4C7B    4FVT    4FZ3    4HD8    4JSR    4JT8    4JT9    4O8Z    4V1C    5BWN    5BWO    5D7N    5H4D    5YTK   
CATH (Classification of proteins structures)3GLR    3GLS    3GLT    3GLU    4BN4    4BN5    4BV3    4BVB    4BVE    4BVF    4BVG    4BVH    4C78    4C7B    4FVT    4FZ3    4HD8    4JSR    4JT8    4JT9    4O8Z    4V1C    5BWN    5BWO    5D7N    5H4D    5YTK   
SuperfamilyQ9NTG7
Human Protein Atlas [tissue]ENSG00000142082-SIRT3 [tissue]
Peptide AtlasQ9NTG7
HPRD06836
IPIIPI00183171   IPI00168319   IPI00984505   IPI00922710   IPI00922604   IPI00921854   IPI00980395   IPI00976754   IPI00982768   IPI00985084   IPI00978713   
Protein Interaction databases
DIP (DOE-UCLA)Q9NTG7
IntAct (EBI)Q9NTG7
FunCoupENSG00000142082
BioGRIDSIRT3
STRING (EMBL)SIRT3
ZODIACSIRT3
Ontologies - Pathways
QuickGOQ9NTG7
Ontology : AmiGONAD+ ADP-ribosyltransferase activity  protein binding  mitochondrion  mitochondrial matrix  mitochondrial matrix  protein ADP-ribosylation  protein deacetylation  mitochondrion organization  aging  zinc ion binding  aerobic respiration  histone deacetylation  NAD-dependent histone deacetylase activity  enzyme binding  positive regulation of insulin secretion  protein-containing complex  NAD-dependent protein deacetylase activity  peptidyl-lysine deacetylation  sequence-specific DNA binding  negative regulation of ERK1 and ERK2 cascade  NAD+ binding  negative regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBINAD+ ADP-ribosyltransferase activity  protein binding  mitochondrion  mitochondrial matrix  mitochondrial matrix  protein ADP-ribosylation  protein deacetylation  mitochondrion organization  aging  zinc ion binding  aerobic respiration  histone deacetylation  NAD-dependent histone deacetylase activity  enzyme binding  positive regulation of insulin secretion  protein-containing complex  NAD-dependent protein deacetylase activity  peptidyl-lysine deacetylation  sequence-specific DNA binding  negative regulation of ERK1 and ERK2 cascade  NAD+ binding  negative regulation of reactive oxygen species metabolic process  
NDEx NetworkSIRT3
Atlas of Cancer Signalling NetworkSIRT3
Wikipedia pathwaysSIRT3
Orthology - Evolution
OrthoDB23410
GeneTree (enSembl)ENSG00000142082
Phylogenetic Trees/Animal Genes : TreeFamSIRT3
HOVERGENQ9NTG7
HOGENOMQ9NTG7
Homologs : HomoloGeneSIRT3
Homology/Alignments : Family Browser (UCSC)SIRT3
Gene fusions - Rearrangements
Fusion : MitelmanSPON1/SIRT3 [11p15.2/11p15.5]  [t(11;11)(p15;p15)]  
Fusion PortalSPON1 11p15.2 SIRT3 11p15.5 LGG
Fusion : QuiverSIRT3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIRT3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIRT3
dbVarSIRT3
ClinVarSIRT3
1000_GenomesSIRT3 
Exome Variant ServerSIRT3
ExAC (Exome Aggregation Consortium)ENSG00000142082
GNOMAD BrowserENSG00000142082
Varsome BrowserSIRT3
Genetic variants : HAPMAP23410
Genomic Variants (DGV)SIRT3 [DGVbeta]
DECIPHERSIRT3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIRT3 
Mutations
ICGC Data PortalSIRT3 
TCGA Data PortalSIRT3 
Broad Tumor PortalSIRT3
OASIS PortalSIRT3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIRT3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIRT3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch SIRT3
DgiDB (Drug Gene Interaction Database)SIRT3
DoCM (Curated mutations)SIRT3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIRT3 (select a term)
intoGenSIRT3
Cancer3DSIRT3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604481   
Orphanet
DisGeNETSIRT3
MedgenSIRT3
Genetic Testing Registry SIRT3
NextProtQ9NTG7 [Medical]
TSGene23410
GENETestsSIRT3
Target ValidationSIRT3
Huge Navigator SIRT3 [HugePedia]
snp3D : Map Gene to Disease23410
BioCentury BCIQSIRT3
ClinGenSIRT3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23410
Chemical/Pharm GKB GenePA37936
Clinical trialSIRT3
Miscellaneous
canSAR (ICR)SIRT3 (select the gene name)
Probes
Litterature
PubMed193 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIRT3
EVEXSIRT3
GoPubMedSIRT3
iHOPSIRT3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:52:20 CEST 2018
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.