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SIRT4 (sirtuin 4)

Identity

Alias_namessirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4
sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)
Alias_symbol (synonym)SIR2L4
Other alias
HGNC (Hugo) SIRT4
LocusID (NCBI) 23409
Atlas_Id 53767
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 120302321 and ends at 120313242 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIRT4   14932
Cards
Entrez_Gene (NCBI)SIRT4  23409  sirtuin 4
AliasesSIR2L4
GeneCards (Weizmann)SIRT4
Ensembl hg19 (Hinxton)ENSG00000089163 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000089163 [Gene_View]  ENSG00000089163 [Sequence]  chr12:120302321-120313242 [Contig_View]  SIRT4 [Vega]
ICGC DataPortalENSG00000089163
TCGA cBioPortalSIRT4
AceView (NCBI)SIRT4
Genatlas (Paris)SIRT4
WikiGenes23409
SOURCE (Princeton)SIRT4
Genetics Home Reference (NIH)SIRT4
Genomic and cartography
GoldenPath hg38 (UCSC)SIRT4  -     chr12:120302321-120313242 +  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIRT4  -     12q24.31   [Description]    (hg19-Feb_2009)
EnsemblSIRT4 - 12q24.31 [CytoView hg19]  SIRT4 - 12q24.31 [CytoView hg38]
Mapping of homologs : NCBISIRT4 [Mapview hg19]  SIRT4 [Mapview hg38]
OMIM604482   
Gene and transcription
Genbank (Entrez)AF083109 BC034736 BC109319 BC109320 BP232525
RefSeq transcript (Entrez)NM_012240
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIRT4
Cluster EST : UnigeneHs.50861 [ NCBI ]
CGAP (NCI)Hs.50861
Alternative Splicing GalleryENSG00000089163
Gene ExpressionSIRT4 [ NCBI-GEO ]   SIRT4 [ EBI - ARRAY_EXPRESS ]   SIRT4 [ SEEK ]   SIRT4 [ MEM ]
Gene Expression Viewer (FireBrowse)SIRT4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23409
GTEX Portal (Tissue expression)SIRT4
Human Protein AtlasENSG00000089163-SIRT4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6E7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6E7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6E7
Splice isoforms : SwissVarQ9Y6E7
PhosPhoSitePlusQ9Y6E7
Domaine pattern : Prosite (Expaxy)SIRTUIN (PS50305)   
Domains : Interpro (EBI)DHS-like_NAD/FAD-binding_dom    Sirtuin    Sirtuin_cat_small_dom_sf    Sirtuin_class_II    Ssirtuin_cat_dom   
Domain families : Pfam (Sanger)SIR2 (PF02146)   
Domain families : Pfam (NCBI)pfam02146   
Conserved Domain (NCBI)SIRT4
DMDM Disease mutations23409
Blocks (Seattle)SIRT4
SuperfamilyQ9Y6E7
Human Protein Atlas [tissue]ENSG00000089163-SIRT4 [tissue]
Peptide AtlasQ9Y6E7
HPRD06837
IPIIPI00305620   IPI01015838   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6E7
IntAct (EBI)Q9Y6E7
FunCoupENSG00000089163
BioGRIDSIRT4
STRING (EMBL)SIRT4
ZODIACSIRT4
Ontologies - Pathways
QuickGOQ9Y6E7
Ontology : AmiGOregulation of glutamine family amino acid metabolic process  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  mitochondrial matrix  chromatin silencing  protein ADP-ribosylation  protein ADP-ribosylation  glutamine metabolic process  cellular response to DNA damage stimulus  mitochondrion organization  zinc ion binding  negative regulation of cardiac muscle cell apoptotic process  NAD-dependent protein deacetylase activity  peptidyl-lysine deacetylation  negative regulation of fatty acid oxidation  negative regulation of fatty acid oxidation  negative regulation of insulin secretion  positive regulation of lipid biosynthetic process  biotinidase activity  lipoamidase activity  NAD+ binding  cellular response to hypoxia  tricarboxylic acid metabolic process  negative regulation of protein processing involved in protein targeting to mitochondrion  regulation of pyruvate dehydrogenase activity  
Ontology : EGO-EBIregulation of glutamine family amino acid metabolic process  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  mitochondrial matrix  chromatin silencing  protein ADP-ribosylation  protein ADP-ribosylation  glutamine metabolic process  cellular response to DNA damage stimulus  mitochondrion organization  zinc ion binding  negative regulation of cardiac muscle cell apoptotic process  NAD-dependent protein deacetylase activity  peptidyl-lysine deacetylation  negative regulation of fatty acid oxidation  negative regulation of fatty acid oxidation  negative regulation of insulin secretion  positive regulation of lipid biosynthetic process  biotinidase activity  lipoamidase activity  NAD+ binding  cellular response to hypoxia  tricarboxylic acid metabolic process  negative regulation of protein processing involved in protein targeting to mitochondrion  regulation of pyruvate dehydrogenase activity  
NDEx NetworkSIRT4
Atlas of Cancer Signalling NetworkSIRT4
Wikipedia pathwaysSIRT4
Orthology - Evolution
OrthoDB23409
GeneTree (enSembl)ENSG00000089163
Phylogenetic Trees/Animal Genes : TreeFamSIRT4
HOVERGENQ9Y6E7
HOGENOMQ9Y6E7
Homologs : HomoloGeneSIRT4
Homology/Alignments : Family Browser (UCSC)SIRT4
Gene fusions - Rearrangements
Fusion : QuiverSIRT4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIRT4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIRT4
dbVarSIRT4
ClinVarSIRT4
1000_GenomesSIRT4 
Exome Variant ServerSIRT4
ExAC (Exome Aggregation Consortium)ENSG00000089163
GNOMAD BrowserENSG00000089163
Varsome BrowserSIRT4
Genetic variants : HAPMAP23409
Genomic Variants (DGV)SIRT4 [DGVbeta]
DECIPHERSIRT4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIRT4 
Mutations
ICGC Data PortalSIRT4 
TCGA Data PortalSIRT4 
Broad Tumor PortalSIRT4
OASIS PortalSIRT4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIRT4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIRT4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIRT4
DgiDB (Drug Gene Interaction Database)SIRT4
DoCM (Curated mutations)SIRT4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIRT4 (select a term)
intoGenSIRT4
Cancer3DSIRT4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604482   
Orphanet
DisGeNETSIRT4
MedgenSIRT4
Genetic Testing Registry SIRT4
NextProtQ9Y6E7 [Medical]
TSGene23409
GENETestsSIRT4
Target ValidationSIRT4
Huge Navigator SIRT4 [HugePedia]
snp3D : Map Gene to Disease23409
BioCentury BCIQSIRT4
ClinGenSIRT4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23409
Chemical/Pharm GKB GenePA37937
Clinical trialSIRT4
Miscellaneous
canSAR (ICR)SIRT4 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIRT4
EVEXSIRT4
GoPubMedSIRT4
iHOPSIRT4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:39:11 CET 2018

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