Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SIRT5 (sirtuin 5)

Identity

Alias_namessirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 5
sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)
Other aliasSIR2L5
HGNC (Hugo) SIRT5
LocusID (NCBI) 23408
Atlas_Id 53478
Location 6p23  [Link to chromosome band 6p23]
Location_base_pair Starts at 13574529 and ends at 13605738 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIRT5   14933
Cards
Entrez_Gene (NCBI)SIRT5  23408  sirtuin 5
AliasesSIR2L5
GeneCards (Weizmann)SIRT5
Ensembl hg19 (Hinxton)ENSG00000124523 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124523 [Gene_View]  ENSG00000124523 [Sequence]  chr6:13574529-13605738 [Contig_View]  SIRT5 [Vega]
ICGC DataPortalENSG00000124523
TCGA cBioPortalSIRT5
AceView (NCBI)SIRT5
Genatlas (Paris)SIRT5
WikiGenes23408
SOURCE (Princeton)SIRT5
Genetics Home Reference (NIH)SIRT5
Genomic and cartography
GoldenPath hg38 (UCSC)SIRT5  -     chr6:13574529-13605738 +  6p23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIRT5  -     6p23   [Description]    (hg19-Feb_2009)
EnsemblSIRT5 - 6p23 [CytoView hg19]  SIRT5 - 6p23 [CytoView hg38]
Mapping of homologs : NCBISIRT5 [Mapview hg19]  SIRT5 [Mapview hg38]
OMIM604483   
Gene and transcription
Genbank (Entrez)AF083110 AI969140 AJ420496 AK000355 AK094269
RefSeq transcript (Entrez)NM_001193267 NM_001242827 NM_012241 NM_031244
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIRT5
Cluster EST : UnigeneHs.594133 [ NCBI ]
CGAP (NCI)Hs.594133
Alternative Splicing GalleryENSG00000124523
Gene ExpressionSIRT5 [ NCBI-GEO ]   SIRT5 [ EBI - ARRAY_EXPRESS ]   SIRT5 [ SEEK ]   SIRT5 [ MEM ]
Gene Expression Viewer (FireBrowse)SIRT5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23408
GTEX Portal (Tissue expression)SIRT5
Human Protein AtlasENSG00000124523-SIRT5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NXA8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NXA8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NXA8
Splice isoforms : SwissVarQ9NXA8
PhosPhoSitePlusQ9NXA8
Domaine pattern : Prosite (Expaxy)SIRTUIN (PS50305)   
Domains : Interpro (EBI)DHS-like_NAD/FAD-binding_dom    Sirtuin    Sirtuin_cat_small_dom_sf    Sirtuin_class_III    Ssirtuin_cat_dom   
Domain families : Pfam (Sanger)SIR2 (PF02146)   
Domain families : Pfam (NCBI)pfam02146   
Conserved Domain (NCBI)SIRT5
DMDM Disease mutations23408
Blocks (Seattle)SIRT5
PDB (SRS)2B4Y    2NYR    3RIG    3RIY    4F4U    4F56    4G1C    4HDA    5BWL    6EQS   
PDB (PDBSum)2B4Y    2NYR    3RIG    3RIY    4F4U    4F56    4G1C    4HDA    5BWL    6EQS   
PDB (IMB)2B4Y    2NYR    3RIG    3RIY    4F4U    4F56    4G1C    4HDA    5BWL    6EQS   
PDB (RSDB)2B4Y    2NYR    3RIG    3RIY    4F4U    4F56    4G1C    4HDA    5BWL    6EQS   
Structural Biology KnowledgeBase2B4Y    2NYR    3RIG    3RIY    4F4U    4F56    4G1C    4HDA    5BWL    6EQS   
SCOP (Structural Classification of Proteins)2B4Y    2NYR    3RIG    3RIY    4F4U    4F56    4G1C    4HDA    5BWL    6EQS   
CATH (Classification of proteins structures)2B4Y    2NYR    3RIG    3RIY    4F4U    4F56    4G1C    4HDA    5BWL    6EQS   
SuperfamilyQ9NXA8
Human Protein Atlas [tissue]ENSG00000124523-SIRT5 [tissue]
Peptide AtlasQ9NXA8
HPRD06838
IPIIPI00016807   IPI00010331   IPI01012048   IPI00844137   IPI00984913   
Protein Interaction databases
DIP (DOE-UCLA)Q9NXA8
IntAct (EBI)Q9NXA8
FunCoupENSG00000124523
BioGRIDSIRT5
STRING (EMBL)SIRT5
ZODIACSIRT5
Ontologies - Pathways
QuickGOQ9NXA8
Ontology : AmiGONAD+ ADP-ribosyltransferase activity  nucleus  mitochondrion  mitochondrial inner membrane  mitochondrial intermembrane space  mitochondrial matrix  mitochondrial matrix  cytosol  chromatin silencing  protein ADP-ribosylation  protein deacetylation  protein deacetylation  mitochondrion organization  zinc ion binding  regulation of ketone biosynthetic process  negative regulation of cardiac muscle cell apoptotic process  response to nutrient levels  NAD-dependent protein deacetylase activity  protein demalonylation  peptidyl-lysine demalonylation  protein desuccinylation  peptidyl-lysine desuccinylation  protein-malonyllysine demalonylase activity  protein-succinyllysine desuccinylase activity  protein-glutaryllysine deglutarylase activity  protein deglutarylation  peptidyl-lysine deglutarylation  NAD+ binding  negative regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBINAD+ ADP-ribosyltransferase activity  nucleus  mitochondrion  mitochondrial inner membrane  mitochondrial intermembrane space  mitochondrial matrix  mitochondrial matrix  cytosol  chromatin silencing  protein ADP-ribosylation  protein deacetylation  protein deacetylation  mitochondrion organization  zinc ion binding  regulation of ketone biosynthetic process  negative regulation of cardiac muscle cell apoptotic process  response to nutrient levels  NAD-dependent protein deacetylase activity  protein demalonylation  peptidyl-lysine demalonylation  protein desuccinylation  peptidyl-lysine desuccinylation  protein-malonyllysine demalonylase activity  protein-succinyllysine desuccinylase activity  protein-glutaryllysine deglutarylase activity  protein deglutarylation  peptidyl-lysine deglutarylation  NAD+ binding  negative regulation of reactive oxygen species metabolic process  
NDEx NetworkSIRT5
Atlas of Cancer Signalling NetworkSIRT5
Wikipedia pathwaysSIRT5
Orthology - Evolution
OrthoDB23408
GeneTree (enSembl)ENSG00000124523
Phylogenetic Trees/Animal Genes : TreeFamSIRT5
HOVERGENQ9NXA8
HOGENOMQ9NXA8
Homologs : HomoloGeneSIRT5
Homology/Alignments : Family Browser (UCSC)SIRT5
Gene fusions - Rearrangements
Fusion : QuiverSIRT5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIRT5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIRT5
dbVarSIRT5
ClinVarSIRT5
1000_GenomesSIRT5 
Exome Variant ServerSIRT5
ExAC (Exome Aggregation Consortium)ENSG00000124523
GNOMAD BrowserENSG00000124523
Varsome BrowserSIRT5
Genetic variants : HAPMAP23408
Genomic Variants (DGV)SIRT5 [DGVbeta]
DECIPHERSIRT5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIRT5 
Mutations
ICGC Data PortalSIRT5 
TCGA Data PortalSIRT5 
Broad Tumor PortalSIRT5
OASIS PortalSIRT5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIRT5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIRT5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch SIRT5
DgiDB (Drug Gene Interaction Database)SIRT5
DoCM (Curated mutations)SIRT5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIRT5 (select a term)
intoGenSIRT5
Cancer3DSIRT5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604483   
Orphanet
DisGeNETSIRT5
MedgenSIRT5
Genetic Testing Registry SIRT5
NextProtQ9NXA8 [Medical]
TSGene23408
GENETestsSIRT5
Target ValidationSIRT5
Huge Navigator SIRT5 [HugePedia]
snp3D : Map Gene to Disease23408
BioCentury BCIQSIRT5
ClinGenSIRT5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23408
Chemical/Pharm GKB GenePA37938
Clinical trialSIRT5
Miscellaneous
canSAR (ICR)SIRT5 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIRT5
EVEXSIRT5
GoPubMedSIRT5
iHOPSIRT5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:39:11 CET 2018

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