SIRT6 (sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae))

Identity

Other names	SIR2L6
HGNC	SIRT6
Location	19p13.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	SIRT6   14934
Entrez_Gene	SIRT6  51548  sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
	Cards
GeneCards	SIRT6
Ensembl	SIRT6 [Search_View]   ENSG00000077463 [Gene_View]
Genatlas	SIRT6
GeneLynx	SIRT6
eGenome	SIRT6
euGene	51548
	Genomic and cartography
GoldenPath	SIRT6  -  19p13.3   chr19:4125106-4133596 -  19p13.3   [Description]    (hg18-March_2006)
Ensembl	SIRT6 - 19p13.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	SIRT6
	Gene and transcription
Genbank	AF233396 [ ENTREZ ]
Genbank	AK074810 [ ENTREZ ]
Genbank	AK225567 [ ENTREZ ]
Genbank	AK293348 [ ENTREZ ]
Genbank	AK315048 [ ENTREZ ]
RefSeq	NM_016539 [ SRS ]    NM_016539 [ ENTREZ ]
RefSeq	AC_000062 [ SRS ]    AC_000062 [ ENTREZ ]
RefSeq	AC_000151 [ SRS ]    AC_000151 [ ENTREZ ]
RefSeq	NC_000019 [ SRS ]    NC_000019 [ ENTREZ ]
RefSeq	NT_011255 [ SRS ]    NT_011255 [ ENTREZ ]
RefSeq	NW_001838477 [ SRS ]    NW_001838477 [ ENTREZ ]
RefSeq	NW_927173 [ SRS ]    NW_927173 [ ENTREZ ]
AceView	SIRT6 AceView - NCBI
Unigene	Hs.423756 [ SRS ]    Hs.423756 [ NCBI ]     HS423756 [ spliceNest ]
Fast-db	2470 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q8N6T7 [ SRS]    Q8N6T7 [ EXPASY ]     Q8N6T7 [ INTERPRO ]     Q8N6T7 [ UNIPROT ]
Prosite	PS50305 SIRTUIN [ SRS ]    PS50305 SIRTUIN [ Expasy ]
Interpro	IPR003000 NAD-dep_histone_deAcase_SIR2 [ SRS ]    IPR003000 NAD-dep_histone_deAcase_SIR2 [ EBI ]
CluSTr	Q8N6T7
Pfam	PF02146 SIR2 [ SRS ]    PF02146 SIR2 [ Sanger ]    pfam02146 [ NCBI-CDD ]
Blocks	Q8N6T7
HPRD	12093
	Protein Interaction databases
DIP	Q8N6T7
IntAct	Q8N6T7
	Polymorphism : SNP, mutations, diseases
OMIM	606211    [ map ]
GENECLINICS	606211
SNP	SIRT6 [dbSNP-NCBI]
SNP	NM_016539 [SNP-NCI]
SNP	SIRT6 [GeneSNPs - Utah]  SIRT6] [HGBASE - SRS]
HAPMAP	SIRT6 [HAPMAP]
COSMIC	SIRT6 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	SIRT6
	General knowledge
Family Browser	SIRT6 [UCSC Family Browser]
SOURCE	NM_016539
SMD	Hs.423756
SAGE	Hs.423756
Enzyme	2.4.2.31 [ Enzyme-Expasy ]   2.4.2.31 [ Enzyme-SRS ]   2.4.2.31 [ IntEnz-EBI ]   2.4.2.31 [ BRENDA ]   2.4.2.31 [ KEGG ]   2.4.2.31 [ WIT ]
GO	DNA binding [Amigo]  DNA binding
GO	NAD(P)+-protein-arginine ADP-ribosyltransferase activity [Amigo]  NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO	nucleus [Amigo]  nucleus
GO	chromatin silencing complex [Amigo]  chromatin silencing complex
GO	chromatin silencing [Amigo]  chromatin silencing
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	protein amino acid ADP-ribosylation [Amigo]  protein amino acid ADP-ribosylation
GO	protein amino acid deacetylation [Amigo]  protein amino acid deacetylation
GO	zinc ion binding [Amigo]  zinc ion binding
GO	transferase activity, transferring glycosyl groups [Amigo]  transferase activity, transferring glycosyl groups
GO	NAD-dependent histone deacetylase activity [Amigo]  NAD-dependent histone deacetylase activity
GO	metal ion binding [Amigo]  metal ion binding
GO	NAD binding [Amigo]  NAD binding
PubGene	SIRT6
TreeFam	SIRT6
CTD	51548 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	SIRT6 Related clones (RZPD - Berlin)
	PubMed
PubMed	12 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:31:53 2008