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SIRT6 (sirtuin 6)

Identity

Alias_namessirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6
sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
Other aliasSIR2L6
HGNC (Hugo) SIRT6
LocusID (NCBI) 51548
Atlas_Id 47142
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 4174109 and ends at 4182604 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SIRT6 (19p13.3) / CERS4 (19p13.2)SIRT6 (19p13.3) / SDC3 (1p35.2)SIRT6 19p13.3 / CERS4 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIRT6   14934
Cards
Entrez_Gene (NCBI)SIRT6  51548  sirtuin 6
AliasesSIR2L6
GeneCards (Weizmann)SIRT6
Ensembl hg19 (Hinxton)ENSG00000077463 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000077463 [Gene_View]  chr19:4174109-4182604 [Contig_View]  SIRT6 [Vega]
ICGC DataPortalENSG00000077463
TCGA cBioPortalSIRT6
AceView (NCBI)SIRT6
Genatlas (Paris)SIRT6
WikiGenes51548
SOURCE (Princeton)SIRT6
Genetics Home Reference (NIH)SIRT6
Genomic and cartography
GoldenPath hg38 (UCSC)SIRT6  -     chr19:4174109-4182604 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIRT6  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblSIRT6 - 19p13.3 [CytoView hg19]  SIRT6 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBISIRT6 [Mapview hg19]  SIRT6 [Mapview hg38]
OMIM606211   
Gene and transcription
Genbank (Entrez)AF233396 AK074810 AK225567 AK293348 AK299420
RefSeq transcript (Entrez)NM_001193285 NM_001321058 NM_001321059 NM_001321060 NM_001321061 NM_001321062 NM_001321063 NM_001321064 NM_016539
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIRT6
Cluster EST : UnigeneHs.423756 [ NCBI ]
CGAP (NCI)Hs.423756
Alternative Splicing GalleryENSG00000077463
Gene ExpressionSIRT6 [ NCBI-GEO ]   SIRT6 [ EBI - ARRAY_EXPRESS ]   SIRT6 [ SEEK ]   SIRT6 [ MEM ]
Gene Expression Viewer (FireBrowse)SIRT6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51548
GTEX Portal (Tissue expression)SIRT6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N6T7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N6T7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N6T7
Splice isoforms : SwissVarQ8N6T7
Catalytic activity : Enzyme3.5.1.- [ Enzyme-Expasy ]   3.5.1.-3.5.1.- [ IntEnz-EBI ]   3.5.1.- [ BRENDA ]   3.5.1.- [ KEGG ]   
PhosPhoSitePlusQ8N6T7
Domaine pattern : Prosite (Expaxy)SIRTUIN (PS50305)   
Domains : Interpro (EBI)DHS-like_NAD/FAD-binding_dom    Sirtuin    Ssirtuin_cat_dom   
Domain families : Pfam (Sanger)SIR2 (PF02146)   
Domain families : Pfam (NCBI)pfam02146   
Conserved Domain (NCBI)SIRT6
DMDM Disease mutations51548
Blocks (Seattle)SIRT6
PDB (SRS)3K35    3PKI    3PKJ    3ZG6    5MF6    5MFP    5MFZ    5MGN   
PDB (PDBSum)3K35    3PKI    3PKJ    3ZG6    5MF6    5MFP    5MFZ    5MGN   
PDB (IMB)3K35    3PKI    3PKJ    3ZG6    5MF6    5MFP    5MFZ    5MGN   
PDB (RSDB)3K35    3PKI    3PKJ    3ZG6    5MF6    5MFP    5MFZ    5MGN   
Structural Biology KnowledgeBase3K35    3PKI    3PKJ    3ZG6    5MF6    5MFP    5MFZ    5MGN   
SCOP (Structural Classification of Proteins)3K35    3PKI    3PKJ    3ZG6    5MF6    5MFP    5MFZ    5MGN   
CATH (Classification of proteins structures)3K35    3PKI    3PKJ    3ZG6    5MF6    5MFP    5MFZ    5MGN   
SuperfamilyQ8N6T7
Human Protein AtlasENSG00000077463
Peptide AtlasQ8N6T7
HPRD12093
IPIIPI00383640   IPI00396170   IPI00556638   IPI01014474   IPI00332636   
Protein Interaction databases
DIP (DOE-UCLA)Q8N6T7
IntAct (EBI)Q8N6T7
FunCoupENSG00000077463
BioGRIDSIRT6
STRING (EMBL)SIRT6
ZODIACSIRT6
Ontologies - Pathways
QuickGOQ8N6T7
Ontology : AmiGOpost-embryonic cardiac muscle cell growth involved in heart morphogenesis  chromatin binding  transcription corepressor activity  NAD+ ADP-ribosyltransferase activity  NAD(P)+-protein-arginine ADP-ribosyltransferase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nuclear telomeric heterochromatin  nucleolus  cytoplasm  base-excision repair  protein ADP-ribosylation  protein ADP-ribosylation  zinc ion binding  negative regulation of cell proliferation  regulation of double-strand break repair via homologous recombination  NAD-dependent histone deacetylase activity  protein destabilization  response to nutrient levels  positive regulation of chromatin silencing at telomere  positive regulation of telomere maintenance  NAD-dependent protein deacetylase activity  glucose homeostasis  negative regulation of glycolytic process  negative regulation of transcription, DNA-templated  negative regulation of glucose import  NAD-dependent histone deacetylase activity (H3-K9 specific)  positive regulation of fibroblast proliferation  histone H3-K9 modification  NAD+ binding  positive regulation of chondrocyte proliferation  positive regulation of telomeric heterochromatin assembly  positive regulation blood vessel branching  positive regulation of vascular endothelial cell proliferation  histone H3-K9 deacetylation  positive regulation of stem cell proliferation  
Ontology : EGO-EBIpost-embryonic cardiac muscle cell growth involved in heart morphogenesis  chromatin binding  transcription corepressor activity  NAD+ ADP-ribosyltransferase activity  NAD(P)+-protein-arginine ADP-ribosyltransferase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nuclear telomeric heterochromatin  nucleolus  cytoplasm  base-excision repair  protein ADP-ribosylation  protein ADP-ribosylation  zinc ion binding  negative regulation of cell proliferation  regulation of double-strand break repair via homologous recombination  NAD-dependent histone deacetylase activity  protein destabilization  response to nutrient levels  positive regulation of chromatin silencing at telomere  positive regulation of telomere maintenance  NAD-dependent protein deacetylase activity  glucose homeostasis  negative regulation of glycolytic process  negative regulation of transcription, DNA-templated  negative regulation of glucose import  NAD-dependent histone deacetylase activity (H3-K9 specific)  positive regulation of fibroblast proliferation  histone H3-K9 modification  NAD+ binding  positive regulation of chondrocyte proliferation  positive regulation of telomeric heterochromatin assembly  positive regulation blood vessel branching  positive regulation of vascular endothelial cell proliferation  histone H3-K9 deacetylation  positive regulation of stem cell proliferation  
NDEx NetworkSIRT6
Atlas of Cancer Signalling NetworkSIRT6
Wikipedia pathwaysSIRT6
Orthology - Evolution
OrthoDB51548
GeneTree (enSembl)ENSG00000077463
Phylogenetic Trees/Animal Genes : TreeFamSIRT6
HOVERGENQ8N6T7
HOGENOMQ8N6T7
Homologs : HomoloGeneSIRT6
Homology/Alignments : Family Browser (UCSC)SIRT6
Gene fusions - Rearrangements
Fusion : MitelmanSIRT6/CERS4 [19p13.3/19p13.2]  
Fusion: TCGASIRT6 19p13.3 CERS4 19p13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIRT6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIRT6
dbVarSIRT6
ClinVarSIRT6
1000_GenomesSIRT6 
Exome Variant ServerSIRT6
ExAC (Exome Aggregation Consortium)SIRT6 (select the gene name)
Genetic variants : HAPMAP51548
Genomic Variants (DGV)SIRT6 [DGVbeta]
DECIPHERSIRT6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIRT6 
Mutations
ICGC Data PortalSIRT6 
TCGA Data PortalSIRT6 
Broad Tumor PortalSIRT6
OASIS PortalSIRT6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIRT6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIRT6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIRT6
DgiDB (Drug Gene Interaction Database)SIRT6
DoCM (Curated mutations)SIRT6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIRT6 (select a term)
intoGenSIRT6
Cancer3DSIRT6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606211   
Orphanet
MedgenSIRT6
Genetic Testing Registry SIRT6
NextProtQ8N6T7 [Medical]
TSGene51548
GENETestsSIRT6
Target ValidationSIRT6
Huge Navigator SIRT6 [HugePedia]
snp3D : Map Gene to Disease51548
BioCentury BCIQSIRT6
ClinGenSIRT6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51548
Chemical/Pharm GKB GenePA37939
Clinical trialSIRT6
Miscellaneous
canSAR (ICR)SIRT6 (select the gene name)
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIRT6
EVEXSIRT6
GoPubMedSIRT6
iHOPSIRT6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:31:08 CEST 2017

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