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SIRT7 (sirtuin 7)

Identity

Alias (NCBI)SIR2L7
HGNC (Hugo) SIRT7
HGNC Previous namesirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7
 sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
LocusID (NCBI) 51547
Atlas_Id 46278
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 81911939 and ends at 81918176 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NPLOC4 (17q25.3)::SIRT7 (17q25.3)SIRT7 (17q25.3)::CCDC57 (17q25.3)SIRT7 (17q25.3)::LOC100130950 (17p13.2)
SIRT7 17q25.3::CCDC57 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SIRT7   14935
Cards
Entrez_Gene (NCBI)SIRT7    sirtuin 7
AliasesSIR2L7
GeneCards (Weizmann)SIRT7
Ensembl hg19 (Hinxton)ENSG00000187531 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187531 [Gene_View]  ENSG00000187531 [Sequence]  chr17:81911939-81918176 [Contig_View]  SIRT7 [Vega]
ICGC DataPortalENSG00000187531
TCGA cBioPortalSIRT7
AceView (NCBI)SIRT7
Genatlas (Paris)SIRT7
SOURCE (Princeton)SIRT7
Genetics Home Reference (NIH)SIRT7
Genomic and cartography
GoldenPath hg38 (UCSC)SIRT7  -     chr17:81911939-81918176 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIRT7  -     17q25.3   [Description]    (hg19-Feb_2009)
GoldenPathSIRT7 - 17q25.3 [CytoView hg19]  SIRT7 - 17q25.3 [CytoView hg38]
ImmunoBaseENSG00000187531
Genome Data Viewer NCBISIRT7 [Mapview hg19]  
OMIM606212   
Gene and transcription
Genbank (Entrez)AF233395 AK002027 AK094326 AK131437 AK131484
RefSeq transcript (Entrez)NM_016538
Consensus coding sequences : CCDS (NCBI)SIRT7
Gene ExpressionSIRT7 [ NCBI-GEO ]   SIRT7 [ EBI - ARRAY_EXPRESS ]   SIRT7 [ SEEK ]   SIRT7 [ MEM ]
Gene Expression Viewer (FireBrowse)SIRT7 [ Firebrowse - Broad ]
GenevisibleExpression of SIRT7 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51547
GTEX Portal (Tissue expression)SIRT7
Human Protein AtlasENSG00000187531-SIRT7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRC8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRC8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRC8
PhosPhoSitePlusQ9NRC8
Domaine pattern : Prosite (Expaxy)SIRTUIN (PS50305)   
Domains : Interpro (EBI)DHS-like_NAD/FAD-binding_dom    Sirtuin    Ssirtuin_cat_dom   
Domain families : Pfam (Sanger)SIR2 (PF02146)   
Domain families : Pfam (NCBI)pfam02146   
Conserved Domain (NCBI)SIRT7
PDB (RSDB)5IQZ    6G0S   
PDB Europe5IQZ    6G0S   
PDB (PDBSum)5IQZ    6G0S   
PDB (IMB)5IQZ    6G0S   
Structural Biology KnowledgeBase5IQZ    6G0S   
SCOP (Structural Classification of Proteins)5IQZ    6G0S   
CATH (Classification of proteins structures)5IQZ    6G0S   
SuperfamilyQ9NRC8
AlphaFold pdb e-kbQ9NRC8   
Human Protein Atlas [tissue]ENSG00000187531-SIRT7 [tissue]
HPRD12094
Protein Interaction databases
DIP (DOE-UCLA)Q9NRC8
IntAct (EBI)Q9NRC8
BioGRIDSIRT7
STRING (EMBL)SIRT7
ZODIACSIRT7
Ontologies - Pathways
QuickGOQ9NRC8
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  chromatin  osteoblast differentiation  chromatin binding  transcription corepressor activity  histone deacetylase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  nucleolus organizer region  cytoplasm  regulation of gluconeogenesis  DNA repair  regulation of DNA repair  protein deacetylation  cellular response to DNA damage stimulus  positive regulation of transcription involved in exit from mitosis  homologous chromosome pairing at meiosis  rRNA transcription  negative regulation of transposition  regulation of mitochondrion organization  regulation of mitochondrion organization  histone modification  nuclear speck  deacetylase activity  negative regulation of protein ubiquitination  NAD-dependent protein deacetylase activity  site of double-strand break  peptidyl-lysine desuccinylation  protein-succinyllysine desuccinylase activity  positive regulation of transcription by RNA polymerase II  regulation of protein export from nucleus  metal ion binding  protein-glutaryllysine deglutarylase activity  protein deglutarylation  peptidyl-lysine deglutarylation  R-loop disassembly  NAD+ binding  histone H3 deacetylation  histone H3 deacetylation  histone H4 deacetylation  NAD-dependent histone deacetylase activity (H3-K18 specific)  NAD-dependent histone deacetylase activity (H3-K18 specific)  protein depropionylation  protein-propionyllysine depropionylase activity  regulation of transcription of nucleolar large rRNA by RNA polymerase I  histone glutamine methylation  positive regulation of rRNA processing  regulation of double-strand break repair via nonhomologous end joining  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  chromatin  osteoblast differentiation  chromatin binding  transcription corepressor activity  histone deacetylase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  nucleolus organizer region  cytoplasm  regulation of gluconeogenesis  DNA repair  regulation of DNA repair  protein deacetylation  cellular response to DNA damage stimulus  positive regulation of transcription involved in exit from mitosis  homologous chromosome pairing at meiosis  rRNA transcription  negative regulation of transposition  regulation of mitochondrion organization  regulation of mitochondrion organization  histone modification  nuclear speck  deacetylase activity  negative regulation of protein ubiquitination  NAD-dependent protein deacetylase activity  site of double-strand break  peptidyl-lysine desuccinylation  protein-succinyllysine desuccinylase activity  positive regulation of transcription by RNA polymerase II  regulation of protein export from nucleus  metal ion binding  protein-glutaryllysine deglutarylase activity  protein deglutarylation  peptidyl-lysine deglutarylation  R-loop disassembly  NAD+ binding  histone H3 deacetylation  histone H3 deacetylation  histone H4 deacetylation  NAD-dependent histone deacetylase activity (H3-K18 specific)  NAD-dependent histone deacetylase activity (H3-K18 specific)  protein depropionylation  protein-propionyllysine depropionylase activity  regulation of transcription of nucleolar large rRNA by RNA polymerase I  histone glutamine methylation  positive regulation of rRNA processing  regulation of double-strand break repair via nonhomologous end joining  
NDEx NetworkSIRT7
Atlas of Cancer Signalling NetworkSIRT7
Wikipedia pathwaysSIRT7
Orthology - Evolution
OrthoDB51547
GeneTree (enSembl)ENSG00000187531
Phylogenetic Trees/Animal Genes : TreeFamSIRT7
Homologs : HomoloGeneSIRT7
Homology/Alignments : Family Browser (UCSC)SIRT7
Gene fusions - Rearrangements
Fusion : MitelmanNPLOC4::SIRT7 [17q25.3/17q25.3]  
Fusion : MitelmanSIRT7::CCDC57 [17q25.3/17q25.3]  
Fusion : QuiverSIRT7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIRT7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIRT7
dbVarSIRT7
ClinVarSIRT7
MonarchSIRT7
1000_GenomesSIRT7 
Exome Variant ServerSIRT7
GNOMAD BrowserENSG00000187531
Varsome BrowserSIRT7
ACMGSIRT7 variants
VarityQ9NRC8
Genomic Variants (DGV)SIRT7 [DGVbeta]
DECIPHERSIRT7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIRT7 
Mutations
ICGC Data PortalSIRT7 
TCGA Data PortalSIRT7 
Broad Tumor PortalSIRT7
OASIS PortalSIRT7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIRT7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSIRT7
Mutations and Diseases : HGMDSIRT7
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSIRT7
DgiDB (Drug Gene Interaction Database)SIRT7
DoCM (Curated mutations)SIRT7
CIViC (Clinical Interpretations of Variants in Cancer)SIRT7
Cancer3DSIRT7
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606212   
Orphanet
DisGeNETSIRT7
MedgenSIRT7
Genetic Testing Registry SIRT7
NextProtQ9NRC8 [Medical]
GENETestsSIRT7
Target ValidationSIRT7
Huge Navigator SIRT7 [HugePedia]
ClinGenSIRT7
Clinical trials, drugs, therapy
MyCancerGenomeSIRT7
Protein Interactions : CTDSIRT7
Pharm GKB GenePA37940
PharosQ9NRC8
Clinical trialSIRT7
Miscellaneous
canSAR (ICR)SIRT7
HarmonizomeSIRT7
ARCHS4SIRT7
DataMed IndexSIRT7
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSIRT7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Jan 16 18:33:36 CET 2022

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