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SIRT7 (sirtuin 7)

Identity

Alias_namessirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7
sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
Other aliasSIR2L7
HGNC (Hugo) SIRT7
LocusID (NCBI) 51547
Atlas_Id 46278
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 81911939 and ends at 81918182 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NPLOC4 (17q25.3) / SIRT7 (17q25.3)SIRT7 (17q25.3) / CCDC57 (17q25.3)SIRT7 (17q25.3) / LOC100130950 (17p13.2)
SIRT7 17q25.3 / CCDC57 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIRT7   14935
Cards
Entrez_Gene (NCBI)SIRT7  51547  sirtuin 7
AliasesSIR2L7
GeneCards (Weizmann)SIRT7
Ensembl hg19 (Hinxton)ENSG00000187531 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187531 [Gene_View]  chr17:81911939-81918182 [Contig_View]  SIRT7 [Vega]
ICGC DataPortalENSG00000187531
TCGA cBioPortalSIRT7
AceView (NCBI)SIRT7
Genatlas (Paris)SIRT7
WikiGenes51547
SOURCE (Princeton)SIRT7
Genetics Home Reference (NIH)SIRT7
Genomic and cartography
GoldenPath hg38 (UCSC)SIRT7  -     chr17:81911939-81918182 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIRT7  -     17q25.3   [Description]    (hg19-Feb_2009)
EnsemblSIRT7 - 17q25.3 [CytoView hg19]  SIRT7 - 17q25.3 [CytoView hg38]
Mapping of homologs : NCBISIRT7 [Mapview hg19]  SIRT7 [Mapview hg38]
OMIM606212   
Gene and transcription
Genbank (Entrez)AF233395 AK002027 AK094326 AK131437 AK131484
RefSeq transcript (Entrez)NM_016538
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIRT7
Cluster EST : UnigeneHs.514636 [ NCBI ]
CGAP (NCI)Hs.514636
Alternative Splicing GalleryENSG00000187531
Gene ExpressionSIRT7 [ NCBI-GEO ]   SIRT7 [ EBI - ARRAY_EXPRESS ]   SIRT7 [ SEEK ]   SIRT7 [ MEM ]
Gene Expression Viewer (FireBrowse)SIRT7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51547
GTEX Portal (Tissue expression)SIRT7
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRC8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRC8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRC8
Splice isoforms : SwissVarQ9NRC8
Catalytic activity : Enzyme3.5.1.- [ Enzyme-Expasy ]   3.5.1.-3.5.1.- [ IntEnz-EBI ]   3.5.1.- [ BRENDA ]   3.5.1.- [ KEGG ]   
PhosPhoSitePlusQ9NRC8
Domaine pattern : Prosite (Expaxy)SIRTUIN (PS50305)   
Domains : Interpro (EBI)DHS-like_NAD/FAD-binding_dom    Sirtuin    Ssirtuin_cat_dom   
Domain families : Pfam (Sanger)SIR2 (PF02146)   
Domain families : Pfam (NCBI)pfam02146   
Conserved Domain (NCBI)SIRT7
DMDM Disease mutations51547
Blocks (Seattle)SIRT7
SuperfamilyQ9NRC8
Human Protein AtlasENSG00000187531
Peptide AtlasQ9NRC8
HPRD12094
IPIIPI00334648   IPI00383601   IPI01015878   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRC8
IntAct (EBI)Q9NRC8
FunCoupENSG00000187531
BioGRIDSIRT7
STRING (EMBL)SIRT7
ZODIACSIRT7
Ontologies - Pathways
QuickGOQ9NRC8
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  chromatin binding  protein binding  nucleolus  nucleolus organizer region  cytoplasm  positive regulation of transcription involved in exit from mitosis  rRNA transcription  metal ion binding  NAD+ binding  histone H3 deacetylation  histone H4 deacetylation  NAD-dependent histone deacetylase activity (H3-K18 specific)  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  chromatin binding  protein binding  nucleolus  nucleolus organizer region  cytoplasm  positive regulation of transcription involved in exit from mitosis  rRNA transcription  metal ion binding  NAD+ binding  histone H3 deacetylation  histone H4 deacetylation  NAD-dependent histone deacetylase activity (H3-K18 specific)  
NDEx NetworkSIRT7
Atlas of Cancer Signalling NetworkSIRT7
Wikipedia pathwaysSIRT7
Orthology - Evolution
OrthoDB51547
GeneTree (enSembl)ENSG00000187531
Phylogenetic Trees/Animal Genes : TreeFamSIRT7
HOVERGENQ9NRC8
HOGENOMQ9NRC8
Homologs : HomoloGeneSIRT7
Homology/Alignments : Family Browser (UCSC)SIRT7
Gene fusions - Rearrangements
Fusion : MitelmanNPLOC4/SIRT7 [17q25.3/17q25.3]  [dup(17)(q25q25)]  
Fusion : MitelmanSIRT7/CCDC57 [17q25.3/17q25.3]  [t(17;17)(q25;q25)]  
Fusion: TCGASIRT7 17q25.3 CCDC57 17q25.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIRT7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIRT7
dbVarSIRT7
ClinVarSIRT7
1000_GenomesSIRT7 
Exome Variant ServerSIRT7
ExAC (Exome Aggregation Consortium)SIRT7 (select the gene name)
Genetic variants : HAPMAP51547
Genomic Variants (DGV)SIRT7 [DGVbeta]
DECIPHERSIRT7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIRT7 
Mutations
ICGC Data PortalSIRT7 
TCGA Data PortalSIRT7 
Broad Tumor PortalSIRT7
OASIS PortalSIRT7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIRT7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIRT7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIRT7
DgiDB (Drug Gene Interaction Database)SIRT7
DoCM (Curated mutations)SIRT7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIRT7 (select a term)
intoGenSIRT7
Cancer3DSIRT7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606212   
Orphanet
MedgenSIRT7
Genetic Testing Registry SIRT7
NextProtQ9NRC8 [Medical]
TSGene51547
GENETestsSIRT7
Target ValidationSIRT7
Huge Navigator SIRT7 [HugePedia]
snp3D : Map Gene to Disease51547
BioCentury BCIQSIRT7
ClinGenSIRT7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51547
Chemical/Pharm GKB GenePA37940
Clinical trialSIRT7
Miscellaneous
canSAR (ICR)SIRT7 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIRT7
EVEXSIRT7
GoPubMedSIRT7
iHOPSIRT7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:14:33 CEST 2017

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