Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SIX4 (SIX homeobox 4)

Identity

Alias_namessine oculis homeobox (Drosophila) homolog 4
sine oculis homeobox homolog 4 (Drosophila)
Alias_symbol (synonym)AREC3
Other alias
HGNC (Hugo) SIX4
LocusID (NCBI) 51804
Atlas_Id 54944
Location 14q23.1  [Link to chromosome band 14q23]
Location_base_pair Starts at 60709538 and ends at 60724134 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIX4   10890
Cards
Entrez_Gene (NCBI)SIX4  51804  SIX homeobox 4
AliasesAREC3
GeneCards (Weizmann)SIX4
Ensembl hg19 (Hinxton)ENSG00000100625 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100625 [Gene_View]  chr14:60709538-60724134 [Contig_View]  SIX4 [Vega]
ICGC DataPortalENSG00000100625
TCGA cBioPortalSIX4
AceView (NCBI)SIX4
Genatlas (Paris)SIX4
WikiGenes51804
SOURCE (Princeton)SIX4
Genetics Home Reference (NIH)SIX4
Genomic and cartography
GoldenPath hg38 (UCSC)SIX4  -     chr14:60709538-60724134 -  14q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIX4  -     14q23.1   [Description]    (hg19-Feb_2009)
EnsemblSIX4 - 14q23.1 [CytoView hg19]  SIX4 - 14q23.1 [CytoView hg38]
Mapping of homologs : NCBISIX4 [Mapview hg19]  SIX4 [Mapview hg38]
OMIM606342   
Gene and transcription
Genbank (Entrez)AA424469 AF032107 AK308528 AK309358 BC098135
RefSeq transcript (Entrez)NM_017420
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIX4
Cluster EST : UnigeneHs.690393 [ NCBI ]
CGAP (NCI)Hs.690393
Alternative Splicing GalleryENSG00000100625
Gene ExpressionSIX4 [ NCBI-GEO ]   SIX4 [ EBI - ARRAY_EXPRESS ]   SIX4 [ SEEK ]   SIX4 [ MEM ]
Gene Expression Viewer (FireBrowse)SIX4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51804
GTEX Portal (Tissue expression)SIX4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UIU6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UIU6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UIU6
Splice isoforms : SwissVarQ9UIU6
PhosPhoSitePlusQ9UIU6
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    SIX1_SD   
Domain families : Pfam (Sanger)Homeobox (PF00046)    SIX1_SD (PF16878)   
Domain families : Pfam (NCBI)pfam00046    pfam16878   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)SIX4
DMDM Disease mutations51804
Blocks (Seattle)SIX4
SuperfamilyQ9UIU6
Human Protein AtlasENSG00000100625
Peptide AtlasQ9UIU6
HPRD06960
IPIIPI00006525   IPI01024932   IPI01026553   
Protein Interaction databases
DIP (DOE-UCLA)Q9UIU6
IntAct (EBI)Q9UIU6
FunCoupENSG00000100625
BioGRIDSIX4
STRING (EMBL)SIX4
ZODIACSIX4
Ontologies - Pathways
QuickGOQ9UIU6
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  nucleus  cytoplasm  transcription from RNA polymerase II promoter  skeletal muscle tissue development  regulation of synaptic growth at neuromuscular junction  male gonad development  anatomical structure morphogenesis  male sex determination  olfactory placode formation  regulation of protein localization  protein localization to nucleus  inner ear morphogenesis  negative regulation of apoptotic process  negative regulation of neuron apoptotic process  tongue development  sarcomere organization  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  male sex differentiation  thymus development  generation of neurons  embryonic cranial skeleton morphogenesis  regulation of epithelial cell proliferation  myoblast migration  pharyngeal system development  myotome development  fungiform papilla morphogenesis  trigeminal ganglion development  metanephric mesenchyme development  regulation of branch elongation involved in ureteric bud branching  positive regulation of ureteric bud formation  positive regulation of branching involved in ureteric bud morphogenesis  skeletal muscle fiber differentiation  negative regulation of satellite cell differentiation  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  nucleus  cytoplasm  transcription from RNA polymerase II promoter  skeletal muscle tissue development  regulation of synaptic growth at neuromuscular junction  male gonad development  anatomical structure morphogenesis  male sex determination  olfactory placode formation  regulation of protein localization  protein localization to nucleus  inner ear morphogenesis  negative regulation of apoptotic process  negative regulation of neuron apoptotic process  tongue development  sarcomere organization  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  male sex differentiation  thymus development  generation of neurons  embryonic cranial skeleton morphogenesis  regulation of epithelial cell proliferation  myoblast migration  pharyngeal system development  myotome development  fungiform papilla morphogenesis  trigeminal ganglion development  metanephric mesenchyme development  regulation of branch elongation involved in ureteric bud branching  positive regulation of ureteric bud formation  positive regulation of branching involved in ureteric bud morphogenesis  skeletal muscle fiber differentiation  negative regulation of satellite cell differentiation  
Pathways : KEGGTranscriptional misregulation in cancer   
NDEx NetworkSIX4
Atlas of Cancer Signalling NetworkSIX4
Wikipedia pathwaysSIX4
Orthology - Evolution
OrthoDB51804
GeneTree (enSembl)ENSG00000100625
Phylogenetic Trees/Animal Genes : TreeFamSIX4
HOVERGENQ9UIU6
HOGENOMQ9UIU6
Homologs : HomoloGeneSIX4
Homology/Alignments : Family Browser (UCSC)SIX4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIX4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIX4
dbVarSIX4
ClinVarSIX4
1000_GenomesSIX4 
Exome Variant ServerSIX4
ExAC (Exome Aggregation Consortium)SIX4 (select the gene name)
Genetic variants : HAPMAP51804
Genomic Variants (DGV)SIX4 [DGVbeta]
DECIPHERSIX4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIX4 
Mutations
ICGC Data PortalSIX4 
TCGA Data PortalSIX4 
Broad Tumor PortalSIX4
OASIS PortalSIX4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIX4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIX4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIX4
DgiDB (Drug Gene Interaction Database)SIX4
DoCM (Curated mutations)SIX4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIX4 (select a term)
intoGenSIX4
Cancer3DSIX4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606342   
Orphanet
MedgenSIX4
Genetic Testing Registry SIX4
NextProtQ9UIU6 [Medical]
TSGene51804
GENETestsSIX4
Target ValidationSIX4
Huge Navigator SIX4 [HugePedia]
snp3D : Map Gene to Disease51804
BioCentury BCIQSIX4
ClinGenSIX4 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51804
Chemical/Pharm GKB GenePA35790
Clinical trialSIX4
Miscellaneous
canSAR (ICR)SIX4 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIX4
EVEXSIX4
GoPubMedSIX4
iHOPSIX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:07:21 CEST 2017

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