Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SIX5 (SIX homeobox 5)

Identity

Alias_namesDMAHP
sine oculis homeobox (Drosophila) homolog 5
sine oculis homeobox homolog 5 (Drosophila)
Other aliasBOR2
HGNC (Hugo) SIX5
LocusID (NCBI) 147912
Atlas_Id 56442
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 46268043 and ends at 46272497 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIX5   10891
Cards
Entrez_Gene (NCBI)SIX5  147912  SIX homeobox 5
AliasesBOR2; DMAHP
GeneCards (Weizmann)SIX5
Ensembl hg19 (Hinxton)ENSG00000177045 [Gene_View]  chr19:46268043-46272497 [Contig_View]  SIX5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000177045 [Gene_View]  chr19:46268043-46272497 [Contig_View]  SIX5 [Vega]
ICGC DataPortalENSG00000177045
TCGA cBioPortalSIX5
AceView (NCBI)SIX5
Genatlas (Paris)SIX5
WikiGenes147912
SOURCE (Princeton)SIX5
Genetics Home Reference (NIH)SIX5
Genomic and cartography
GoldenPath hg19 (UCSC)SIX5  -     chr19:46268043-46272497 -  19q13.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SIX5  -     19q13.32   [Description]    (hg38-Dec_2013)
EnsemblSIX5 - 19q13.32 [CytoView hg19]  SIX5 - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBISIX5 [Mapview hg19]  SIX5 [Mapview hg38]
OMIM600963   610896   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_175875
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIX5
Cluster EST : UnigeneHs.43314 [ NCBI ]
CGAP (NCI)Hs.43314
Alternative Splicing GalleryENSG00000177045
Gene ExpressionSIX5 [ NCBI-GEO ]   SIX5 [ EBI - ARRAY_EXPRESS ]   SIX5 [ SEEK ]   SIX5 [ MEM ]
Gene Expression Viewer (FireBrowse)SIX5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)147912
GTEX Portal (Tissue expression)SIX5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N196   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N196  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N196
Splice isoforms : SwissVarQ8N196
PhosPhoSitePlusQ8N196
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox_CS    Homeobox_dom    Homeodomain-like    SIX1_SD   
Domain families : Pfam (Sanger)Homeobox (PF00046)    SIX1_SD (PF16878)   
Domain families : Pfam (NCBI)pfam00046    pfam16878   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)SIX5
DMDM Disease mutations147912
Blocks (Seattle)SIX5
SuperfamilyQ8N196
Human Protein AtlasENSG00000177045
Peptide AtlasQ8N196
HPRD09024
IPIIPI00410575   IPI00166124   
Protein Interaction databases
DIP (DOE-UCLA)Q8N196
IntAct (EBI)Q8N196
FunCoupENSG00000177045
BioGRIDSIX5
STRING (EMBL)SIX5
ZODIACSIX5
Ontologies - Pathways
QuickGOQ8N196
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  lens development in camera-type eye  nucleoplasm  cytoplasm  Golgi apparatus  transcription, DNA-templated  spermatid development  intracellular membrane-bounded organelle  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  negative regulation of skeletal muscle satellite cell proliferation  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  lens development in camera-type eye  nucleoplasm  cytoplasm  Golgi apparatus  transcription, DNA-templated  spermatid development  intracellular membrane-bounded organelle  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  negative regulation of skeletal muscle satellite cell proliferation  
NDEx NetworkSIX5
Atlas of Cancer Signalling NetworkSIX5
Wikipedia pathwaysSIX5
Orthology - Evolution
OrthoDB147912
GeneTree (enSembl)ENSG00000177045
Phylogenetic Trees/Animal Genes : TreeFamSIX5
HOVERGENQ8N196
HOGENOMQ8N196
Homologs : HomoloGeneSIX5
Homology/Alignments : Family Browser (UCSC)SIX5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIX5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIX5
dbVarSIX5
ClinVarSIX5
1000_GenomesSIX5 
Exome Variant ServerSIX5
ExAC (Exome Aggregation Consortium)SIX5 (select the gene name)
Genetic variants : HAPMAP147912
Genomic Variants (DGV)SIX5 [DGVbeta]
DECIPHER (Syndromes)19:46268043-46272497  ENSG00000177045
CONAN: Copy Number AnalysisSIX5 
Mutations
ICGC Data PortalSIX5 
TCGA Data PortalSIX5 
Broad Tumor PortalSIX5
OASIS PortalSIX5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIX5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIX5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch SIX5
DgiDB (Drug Gene Interaction Database)SIX5
DoCM (Curated mutations)SIX5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIX5 (select a term)
intoGenSIX5
Cancer3DSIX5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600963    610896   
Orphanet237   
MedgenSIX5
Genetic Testing Registry SIX5
NextProtQ8N196 [Medical]
TSGene147912
GENETestsSIX5
Huge Navigator SIX5 [HugePedia]
snp3D : Map Gene to Disease147912
BioCentury BCIQSIX5
ClinGenSIX5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD147912
Chemical/Pharm GKB GenePA35791
Clinical trialSIX5
Miscellaneous
canSAR (ICR)SIX5 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIX5
EVEXSIX5
GoPubMedSIX5
iHOPSIX5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:19:23 CEST 2017

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