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SIX6 (SIX homeobox 6)

Identity

Alias_namesOPTX2
sine oculis homeobox (Drosophila) homolog 6
sine oculis homeobox homolog 6 (Drosophila)
Alias_symbol (synonym)Six9
Other aliasMCOPCT2
ODRMD
HGNC (Hugo) SIX6
LocusID (NCBI) 4990
Atlas_Id 56130
Location 14q23.1  [Link to chromosome band 14q23]
Location_base_pair Starts at 60975938 and ends at 60978525 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIX6   10892
Cards
Entrez_Gene (NCBI)SIX6  4990  SIX homeobox 6
AliasesMCOPCT2; ODRMD; OPTX2; Six9
GeneCards (Weizmann)SIX6
Ensembl hg19 (Hinxton)ENSG00000184302 [Gene_View]  chr14:60975938-60978525 [Contig_View]  SIX6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000184302 [Gene_View]  chr14:60975938-60978525 [Contig_View]  SIX6 [Vega]
ICGC DataPortalENSG00000184302
TCGA cBioPortalSIX6
AceView (NCBI)SIX6
Genatlas (Paris)SIX6
WikiGenes4990
SOURCE (Princeton)SIX6
Genetics Home Reference (NIH)SIX6
Genomic and cartography
GoldenPath hg19 (UCSC)SIX6  -     chr14:60975938-60978525 +  14q23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SIX6  -     14q23.1   [Description]    (hg38-Dec_2013)
EnsemblSIX6 - 14q23.1 [CytoView hg19]  SIX6 - 14q23.1 [CytoView hg38]
Mapping of homologs : NCBISIX6 [Mapview hg19]  SIX6 [Mapview hg38]
OMIM206900   212550   606326   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_007374
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIX6
Cluster EST : UnigeneHs.194756 [ NCBI ]
CGAP (NCI)Hs.194756
Alternative Splicing GalleryENSG00000184302
Gene ExpressionSIX6 [ NCBI-GEO ]   SIX6 [ EBI - ARRAY_EXPRESS ]   SIX6 [ SEEK ]   SIX6 [ MEM ]
Gene Expression Viewer (FireBrowse)SIX6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4990
GTEX Portal (Tissue expression)SIX6
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95475   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95475  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95475
Splice isoforms : SwissVarO95475
PhosPhoSitePlusO95475
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox_dom    Homeodomain-like    SIX1_SD    SIX6   
Domain families : Pfam (Sanger)Homeobox (PF00046)    SIX1_SD (PF16878)   
Domain families : Pfam (NCBI)pfam00046    pfam16878   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)SIX6
DMDM Disease mutations4990
Blocks (Seattle)SIX6
SuperfamilyO95475
Human Protein AtlasENSG00000184302
Peptide AtlasO95475
HPRD07557
IPIIPI00030821   IPI00977278   
Protein Interaction databases
DIP (DOE-UCLA)O95475
IntAct (EBI)O95475
FunCoupENSG00000184302
BioGRIDSIX6
STRING (EMBL)SIX6
ZODIACSIX6
Ontologies - Pathways
QuickGOO95475
Ontology : AmiGOtranscriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding  eye development  DNA binding  nucleus  transcription from RNA polymerase II promoter  visual perception  animal organ morphogenesis  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBItranscriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding  eye development  DNA binding  nucleus  transcription from RNA polymerase II promoter  visual perception  animal organ morphogenesis  positive regulation of transcription from RNA polymerase II promoter  
NDEx NetworkSIX6
Atlas of Cancer Signalling NetworkSIX6
Wikipedia pathwaysSIX6
Orthology - Evolution
OrthoDB4990
GeneTree (enSembl)ENSG00000184302
Phylogenetic Trees/Animal Genes : TreeFamSIX6
HOVERGENO95475
HOGENOMO95475
Homologs : HomoloGeneSIX6
Homology/Alignments : Family Browser (UCSC)SIX6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIX6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIX6
dbVarSIX6
ClinVarSIX6
1000_GenomesSIX6 
Exome Variant ServerSIX6
ExAC (Exome Aggregation Consortium)SIX6 (select the gene name)
Genetic variants : HAPMAP4990
Genomic Variants (DGV)SIX6 [DGVbeta]
DECIPHER (Syndromes)14:60975938-60978525  ENSG00000184302
CONAN: Copy Number AnalysisSIX6 
Mutations
ICGC Data PortalSIX6 
TCGA Data PortalSIX6 
Broad Tumor PortalSIX6
OASIS PortalSIX6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIX6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIX6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIX6
DgiDB (Drug Gene Interaction Database)SIX6
DoCM (Curated mutations)SIX6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIX6 (select a term)
intoGenSIX6
Cancer3DSIX6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM206900    212550    606326   
Orphanet20095    3713    23319   
MedgenSIX6
Genetic Testing Registry SIX6
NextProtO95475 [Medical]
TSGene4990
GENETestsSIX6
Huge Navigator SIX6 [HugePedia]
snp3D : Map Gene to Disease4990
BioCentury BCIQSIX6
ClinGenSIX6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4990
Chemical/Pharm GKB GenePA35792
Clinical trialSIX6
Miscellaneous
canSAR (ICR)SIX6 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIX6
EVEXSIX6
GoPubMedSIX6
iHOPSIX6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:27:23 CET 2017

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