SKA2 (spindle and kinetochore associated complex subunit 2)

2014-08-01 Affiliation

Identity

HGNC

SKA2

LOCATION

17q22

LOCUSID

348235

ALIAS

FAM33A

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 348235
MIM: 616674
HGNC: 28006
Ensembl: ENSG00000182628

Variants:

dbSNP: 348235
ClinVar: 348235
TCGA: ENSG00000182628
COSMIC: SKA2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000182628	ENST00000330137	Q8WVK7
ENSG00000182628	ENST00000437036	Q8WVK7
ENSG00000182628	ENST00000578105	J3KTC5
ENSG00000182628	ENST00000578519	J3QS74
ENSG00000182628	ENST00000580541	J3KRW9
ENSG00000182628	ENST00000581068	J3KRZ0
ENSG00000182628	ENST00000583380	J3KSP0
ENSG00000182628	ENST00000583976	J3QKN8
ENSG00000182628	ENST00000584089	J3QL03

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases Activate Formins	REACTOME	R-HSA-5663220
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prometaphase	REACTOME	R-HSA-68877
Resolution of Sister Chromatid Cohesion	REACTOME	R-HSA-2500257
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Anaphase	REACTOME	R-HSA-68882
Separation of Sister Chromatids	REACTOME	R-HSA-2467813

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17093495	2006	Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2.	97
22371557	2012	Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction.	57
22483620	2012	Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface.	52
18583474	2008	Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor.	28
26162986	2015	The gene pair PRR11 and SKA2 shares a NF-Y-regulated bidirectional promoter and contributes to lung cancer development.	20
28495837	2017	Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment.	20
27030168	2016	GLUCOCORTICOID RECEPTOR-RELATED GENES: GENOTYPE AND BRAIN GENE EXPRESSION RELATIONSHIPS TO SUICIDE AND MAJOR DEPRESSIVE DISORDER.	9
26824422	2016	Cyclic AMP responsive element-binding protein promotes renal cell carcinoma proliferation probably via the expression of spindle and kinetochore-associated protein 2.	6
28257042	2017	The PRR11-SKA2 Bidirectional Transcription Unit Is Negatively Regulated by p53 through NF-Y in Lung Cancer Cells.	5
30760381	2019	PRR11 and SKA2 gene pair is overexpressed and regulated by p53 in breast cancer.	4

Citation

Dessen P

SKA2 (spindle and kinetochore associated complex subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54621/ska2