SKAP1 (src kinase associated phosphoprotein 1)

2010-11-01  

Identity

HGNC
SKAP1
LOCATION
17q21.32
LOCUSID
8631
ALIAS
HEL-S-81p,SCAP1,SKAP55
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8631
MIM: 604969
HGNC: 15605
Ensembl: ENSG00000141293

Variants:

dbSNP: 8631
ClinVar: 8631
TCGA: ENSG00000141293
COSMIC: SKAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141293ENST00000336915Q86WV1
ENSG00000141293ENST00000579336J3QRG3
ENSG00000141293ENST00000581400J3KS83
ENSG00000141293ENST00000581419J3KSD4
ENSG00000141293ENST00000583844J3QS38
ENSG00000141293ENST00000584709J3QKX8
ENSG00000141293ENST00000584924Q86WV1

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208526322010A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.172
208526322010A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.172
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
203467072010T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.49
126522962003SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates.48
158491952005Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells.33
196677592009SKAP associates with kinetochores and promotes the metaphase-to-anaphase transition.27
216698742011SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.23
216525782012Genetic polymorphisms in androgen receptor-binding sites predict survival in prostate cancer patients receiving androgen-deprivation therapy.22
176586052008SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1.15

Citation

Dessen P

SKAP1 (src kinase associated phosphoprotein 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-11-01

Online version: http://atlasgeneticsoncology.org/gene/51757/skap1