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SKAP1 (src kinase associated phosphoprotein 1)

Identity

Alias (NCBI)HEL-S-81p
SCAP1
SKAP55
HGNC (Hugo) SKAP1
HGNC Alias symbSKAP55
HGNC Previous nameSCAP1
HGNC Previous namesrc family associated phosphoprotein 1
LocusID (NCBI) 8631
Atlas_Id 51757
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 48133442 and ends at 48430214 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CPD (17q11.2) / SKAP1 (17q21.32)FOXK2 (17q25.3) / SKAP1 (17q21.32)KPNB1 (17q21.32) / SKAP1 (17q21.32)
NFE2L1 (17q21.32) / SKAP1 (17q21.32)NSRP1 (17q11.2) / SKAP1 (17q21.32)PEPD (19q13.11) / SKAP1 (17q21.32)
PLA2G2D (1p36.12) / SKAP1 (17q21.32)RARA (17q21.2) / SKAP1 (17q21.32)SCRN2 (17q21.32) / SKAP1 (17q21.32)
SKAP1 (17q21.32) / ABCC11 (16q12.1)SKAP1 (17q21.32) / BCAS3 (17q23.2)SKAP1 (17q21.32) / CALCOCO2 (17q21.32)
SKAP1 (17q21.32) / DNAH17 (17q25.3)SKAP1 (17q21.32) / HOXB3 (17q21.32)SKAP1 (17q21.32) / IKZF3 (17q12)
SKAP1 (17q21.32) / NQO2 (6p25.2)SKAP1 (17q21.32) / TMEM100 (17q22)SKAP1 (17q21.32) / YPEL2 (17q22)
SPAG9 (17q21.33) / SKAP1 (17q21.32)CPD 17q11.2 / SKAP1 17q21.32FOXK2 17q25.3 / SKAP1 17q21.32
KPNB1 17q21.32 / SKAP1 17q21.32NSRP1 17q11.2 / SKAP1 17q21.32PEPD 19q13.11 / SKAP1 17q21.32
RARA 17q21.2 / SKAP1 17q21.32SCRN2 17q21.32 / SKAP1 17q21.32SKAP1 17q21.32 / ABCC11 16q12.1
SKAP1 17q21.32 / BCAS3 17q23.2SKAP1 17q21.32 / CALCOCO2 17q21.32SKAP1 17q21.32 / DNAH17 17q25.3
SKAP1 17q21.32 / HOXB3 17q21.32SKAP1 17q21.32 / IKZF3 17q12SKAP1 17q21.32 / NQO2 6p25.2
SKAP1 17q21.32 / TMEM100 17q22SKAP1 17q21.32 / YPEL2 17q22SPAG9 17q21.33 / SKAP1 17q21.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SKAP1   15605
Cards
Entrez_Gene (NCBI)SKAP1    src kinase associated phosphoprotein 1
AliasesHEL-S-81p; SCAP1; SKAP55
GeneCards (Weizmann)SKAP1
Ensembl hg19 (Hinxton)ENSG00000141293 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141293 [Gene_View]  ENSG00000141293 [Sequence]  chr17:48133442-48430214 [Contig_View]  SKAP1 [Vega]
ICGC DataPortalENSG00000141293
TCGA cBioPortalSKAP1
AceView (NCBI)SKAP1
Genatlas (Paris)SKAP1
SOURCE (Princeton)SKAP1
Genetics Home Reference (NIH)SKAP1
Genomic and cartography
GoldenPath hg38 (UCSC)SKAP1  -     chr17:48133442-48430214 -  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SKAP1  -     17q21.32   [Description]    (hg19-Feb_2009)
GoldenPathSKAP1 - 17q21.32 [CytoView hg19]  SKAP1 - 17q21.32 [CytoView hg38]
ImmunoBaseENSG00000141293
Genome Data Viewer NCBISKAP1 [Mapview hg19]  
OMIM604969   
Gene and transcription
Genbank (Entrez)AK290818 BC039040 BC047870 DR007155 EU668346
RefSeq transcript (Entrez)NM_001075099 NM_003726
Consensus coding sequences : CCDS (NCBI)SKAP1
Gene ExpressionSKAP1 [ NCBI-GEO ]   SKAP1 [ EBI - ARRAY_EXPRESS ]   SKAP1 [ SEEK ]   SKAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)SKAP1 [ Firebrowse - Broad ]
GenevisibleExpression of SKAP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8631
GTEX Portal (Tissue expression)SKAP1
Human Protein AtlasENSG00000141293-SKAP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86WV1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86WV1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86WV1
PhosPhoSitePlusQ86WV1
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    SH3 (PS50002)   
Domains : Interpro (EBI)PH-like_dom_sf    PH_domain    SH3-like_dom_sf    SH3_domain    SKAP1_SH3    SKAP_fam   
Domain families : Pfam (Sanger)PH (PF00169)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam00169    pfam00018   
Domain families : Smart (EMBL)PH (SM00233)  SH3 (SM00326)  
Conserved Domain (NCBI)SKAP1
PDB (RSDB)1U5D   
PDB Europe1U5D   
PDB (PDBSum)1U5D   
PDB (IMB)1U5D   
Structural Biology KnowledgeBase1U5D   
SCOP (Structural Classification of Proteins)1U5D   
CATH (Classification of proteins structures)1U5D   
SuperfamilyQ86WV1
AlphaFold pdb e-kbQ86WV1   
Human Protein Atlas [tissue]ENSG00000141293-SKAP1 [tissue]
HPRD05396
Protein Interaction databases
DIP (DOE-UCLA)Q86WV1
IntAct (EBI)Q86WV1
BioGRIDSKAP1
STRING (EMBL)SKAP1
ZODIACSKAP1
Ontologies - Pathways
QuickGOQ86WV1
Ontology : AmiGOimmunological synapse  positive regulation of cell-matrix adhesion  adaptive immune response  positive regulation of adaptive immune response  protein binding  nucleoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  plasma membrane  cell-cell junction  SH3 domain binding  protein kinase binding  protein phosphatase binding  positive regulation of integrin activation  positive regulation of cell-cell adhesion mediated by integrin  positive regulation of heterotypic cell-cell adhesion  T cell receptor complex  SH2 domain binding  plasma membrane raft  protein-containing complex binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  T cell receptor signaling pathway  protein localization to plasma membrane  positive regulation of leukocyte cell-cell adhesion  
Ontology : EGO-EBIimmunological synapse  positive regulation of cell-matrix adhesion  adaptive immune response  positive regulation of adaptive immune response  protein binding  nucleoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  plasma membrane  cell-cell junction  SH3 domain binding  protein kinase binding  protein phosphatase binding  positive regulation of integrin activation  positive regulation of cell-cell adhesion mediated by integrin  positive regulation of heterotypic cell-cell adhesion  T cell receptor complex  SH2 domain binding  plasma membrane raft  protein-containing complex binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  T cell receptor signaling pathway  protein localization to plasma membrane  positive regulation of leukocyte cell-cell adhesion  
Pathways : KEGGRap1 signaling pathway   
NDEx NetworkSKAP1
Atlas of Cancer Signalling NetworkSKAP1
Wikipedia pathwaysSKAP1
Orthology - Evolution
OrthoDB8631
GeneTree (enSembl)ENSG00000141293
Phylogenetic Trees/Animal Genes : TreeFamSKAP1
Homologs : HomoloGeneSKAP1
Homology/Alignments : Family Browser (UCSC)SKAP1
Gene fusions - Rearrangements
Fusion : MitelmanCPD/SKAP1 [17q11.2/17q21.32]  
Fusion : MitelmanFOXK2/SKAP1 [17q25.3/17q21.32]  
Fusion : MitelmanKPNB1/SKAP1 [17q21.32/17q21.32]  
Fusion : MitelmanNSRP1/SKAP1 [17q11.2/17q21.32]  
Fusion : MitelmanPEPD/SKAP1 [19q13.11/17q21.32]  
Fusion : MitelmanRARA/SKAP1 [17q21.2/17q21.32]  
Fusion : MitelmanSCRN2/SKAP1 [17q21.32/17q21.32]  
Fusion : MitelmanSKAP1/ABCC11 [17q21.32/16q12.1]  
Fusion : MitelmanSKAP1/BCAS3 [17q21.32/17q23.2]  
Fusion : MitelmanSKAP1/CALCOCO2 [17q21.32/17q21.32]  
Fusion : MitelmanSKAP1/DNAH17 [17q21.32/17q25.3]  
Fusion : MitelmanSKAP1/HOXB3 [17q21.32/17q21.32]  
Fusion : MitelmanSKAP1/IKZF3 [17q21.32/17q12]  
Fusion : MitelmanSKAP1/NQO2 [17q21.32/6p25.2]  
Fusion : MitelmanSKAP1/TMEM100 [17q21.32/17q22]  
Fusion : MitelmanSKAP1/YPEL2 [17q21.32/17q22]  
Fusion : MitelmanSPAG9/SKAP1 [17q21.33/17q21.32]  
Fusion : QuiverSKAP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSKAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SKAP1
dbVarSKAP1
ClinVarSKAP1
MonarchSKAP1
1000_GenomesSKAP1 
Exome Variant ServerSKAP1
GNOMAD BrowserENSG00000141293
Varsome BrowserSKAP1
ACMGSKAP1 variants
VarityQ86WV1
Genomic Variants (DGV)SKAP1 [DGVbeta]
DECIPHERSKAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSKAP1 
Mutations
ICGC Data PortalSKAP1 
TCGA Data PortalSKAP1 
Broad Tumor PortalSKAP1
OASIS PortalSKAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSKAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSKAP1
Mutations and Diseases : HGMDSKAP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSKAP1
DgiDB (Drug Gene Interaction Database)SKAP1
DoCM (Curated mutations)SKAP1
CIViC (Clinical Interpretations of Variants in Cancer)SKAP1
Cancer3DSKAP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604969   
Orphanet
DisGeNETSKAP1
MedgenSKAP1
Genetic Testing Registry SKAP1
NextProtQ86WV1 [Medical]
GENETestsSKAP1
Target ValidationSKAP1
Huge Navigator SKAP1 [HugePedia]
ClinGenSKAP1
Clinical trials, drugs, therapy
MyCancerGenomeSKAP1
Protein Interactions : CTDSKAP1
Pharm GKB GenePA162403362
PharosQ86WV1
Clinical trialSKAP1
Miscellaneous
canSAR (ICR)SKAP1
HarmonizomeSKAP1
DataMed IndexSKAP1
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSKAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:31:17 CEST 2021

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