SKIL (SKI like proto-oncogene)

2003-02-01  

Identity

HGNC
LOCATION
3q26.2
LOCUSID
ALIAS
SNO,SnoA,SnoI,SnoN
FUSION GENES

Other Information

Locus ID:

NCBI: 6498
MIM: 165340
HGNC: 10897
Ensembl: ENSG00000136603

Variants:

dbSNP: 6498
ClinVar: 6498
TCGA: ENSG00000136603
COSMIC: SKIL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136603ENST00000259119P12757
ENSG00000136603ENST00000413427P12757
ENSG00000136603ENST00000426052P12757
ENSG00000136603ENST00000458537P12757
ENSG00000136603ENST00000470571H7C4V3
ENSG00000136603ENST00000476188C9J8R9

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
Downregulation of SMAD2/3:SMAD4 transcriptional activityREACTOMER-HSA-2173795
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
175916952007Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.69
175100632007Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling.57
156774582005SnoN is a cell type-specific mediator of transforming growth factor-beta responses.40
170748152007Dual role of SnoN in mammalian tumorigenesis.40
127641352003The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins.38
161097682005Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins.30
169663242006Sumoylated SnoN represses transcription in a promoter-specific manner.30
237644252013Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.28
163144992005Requirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogenic transformation of fibroblast cells.25
176251162007Molecular basis for the cell type specific induction of SnoN expression by hepatocyte growth factor.23

Citation

Dessen P

SKIL (SKI like proto-oncogene)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42304/skil