Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SKP1 (S-phase kinase associated protein 1)

Identity

Alias_namesSKP1A
S-phase kinase-associated protein 1A (p19A)
Alias_symbol (synonym)EMC19
OCP2
TCEB1L
MGC34403
OCP-II
p19A
Other alias
HGNC (Hugo) SKP1
LocusID (NCBI) 6500
Atlas_Id 42306
Location 5q31.1  [Link to chromosome band 5q31]
Location_base_pair Starts at 134156391 and ends at 134177033 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FNBP4 (11p11.2) / SKP1 (5q31.1)MARCH1 (4q32.2) / SKP1 (5q31.1)SKP1 (5q31.1) / AGAP1 (2q37.2)
SKP1 (5q31.1) / CDKL3 (5q31.1)SKP1 (5q31.1) / DCAF8L2 (Xp21.3)SKP1 (5q31.1) / GAPDH (12p13.31)
SKP1 (5q31.1) / HSPB1 (7q11.23)VDAC1 (5q31.1) / SKP1 (5q31.1)VDAC1 5q31.1 / SKP1 5q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Colon: Colorectal adenocarcinoma
Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)SKP1   10899
Cards
Entrez_Gene (NCBI)SKP1  6500  S-phase kinase associated protein 1
AliasesEMC19; OCP-II; OCP2; SKP1A; 
TCEB1L; p19A
GeneCards (Weizmann)SKP1
Ensembl hg19 (Hinxton)ENSG00000113558 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113558 [Gene_View]  chr5:134156391-134177033 [Contig_View]  SKP1 [Vega]
ICGC DataPortalENSG00000113558
TCGA cBioPortalSKP1
AceView (NCBI)SKP1
Genatlas (Paris)SKP1
WikiGenes6500
SOURCE (Princeton)SKP1
Genetics Home Reference (NIH)SKP1
Genomic and cartography
GoldenPath hg38 (UCSC)SKP1  -     chr5:134156391-134177033 -  5q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SKP1  -     5q31.1   [Description]    (hg19-Feb_2009)
EnsemblSKP1 - 5q31.1 [CytoView hg19]  SKP1 - 5q31.1 [CytoView hg38]
Mapping of homologs : NCBISKP1 [Mapview hg19]  SKP1 [Mapview hg38]
OMIM601434   
Gene and transcription
Genbank (Entrez)AI025746 AI028694 AK057110 BC009839 BC020798
RefSeq transcript (Entrez)NM_006930 NM_170679
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SKP1
Cluster EST : UnigeneHs.171626 [ NCBI ]
CGAP (NCI)Hs.171626
Alternative Splicing GalleryENSG00000113558
Gene ExpressionSKP1 [ NCBI-GEO ]   SKP1 [ EBI - ARRAY_EXPRESS ]   SKP1 [ SEEK ]   SKP1 [ MEM ]
Gene Expression Viewer (FireBrowse)SKP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6500
GTEX Portal (Tissue expression)SKP1
Human Protein AtlasENSG00000113558-SKP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63208   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63208  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63208
Splice isoforms : SwissVarP63208
PhosPhoSitePlusP63208
Domains : Interpro (EBI)SKP1    SKP1-like    SKP1/BTB/POZ    Skp1_comp_dimer    Skp1_comp_POZ   
Domain families : Pfam (Sanger)Skp1 (PF01466)    Skp1_POZ (PF03931)   
Domain families : Pfam (NCBI)pfam01466    pfam03931   
Domain families : Smart (EMBL)Skp1 (SM00512)  
Conserved Domain (NCBI)SKP1
DMDM Disease mutations6500
Blocks (Seattle)SKP1
PDB (SRS)1FQV    1FS1    1FS2    1LDK    1P22    2ASS    2AST    2E31    2E32    2OVP    2OVQ    2OVR    3L2O    3WSO    4I6J    5IBK    5JH5    5K35   
PDB (PDBSum)1FQV    1FS1    1FS2    1LDK    1P22    2ASS    2AST    2E31    2E32    2OVP    2OVQ    2OVR    3L2O    3WSO    4I6J    5IBK    5JH5    5K35   
PDB (IMB)1FQV    1FS1    1FS2    1LDK    1P22    2ASS    2AST    2E31    2E32    2OVP    2OVQ    2OVR    3L2O    3WSO    4I6J    5IBK    5JH5    5K35   
PDB (RSDB)1FQV    1FS1    1FS2    1LDK    1P22    2ASS    2AST    2E31    2E32    2OVP    2OVQ    2OVR    3L2O    3WSO    4I6J    5IBK    5JH5    5K35   
Structural Biology KnowledgeBase1FQV    1FS1    1FS2    1LDK    1P22    2ASS    2AST    2E31    2E32    2OVP    2OVQ    2OVR    3L2O    3WSO    4I6J    5IBK    5JH5    5K35   
SCOP (Structural Classification of Proteins)1FQV    1FS1    1FS2    1LDK    1P22    2ASS    2AST    2E31    2E32    2OVP    2OVQ    2OVR    3L2O    3WSO    4I6J    5IBK    5JH5    5K35   
CATH (Classification of proteins structures)1FQV    1FS1    1FS2    1LDK    1P22    2ASS    2AST    2E31    2E32    2OVP    2OVQ    2OVR    3L2O    3WSO    4I6J    5IBK    5JH5    5K35   
SuperfamilyP63208
Human Protein Atlas [tissue]ENSG00000113558-SKP1 [tissue]
Peptide AtlasP63208
HPRD03255
IPIIPI00301364   IPI00172421   IPI00297798   IPI00719311   IPI00973884   IPI00974176   IPI00974248   IPI00985006   IPI00973720   IPI00979610   IPI00978800   IPI00983177   
Protein Interaction databases
DIP (DOE-UCLA)P63208
IntAct (EBI)P63208
FunCoupENSG00000113558
BioGRIDSKP1
STRING (EMBL)SKP1
ZODIACSKP1
Ontologies - Pathways
QuickGOP63208
Ontology : AmiGOG2/M transition of mitotic cell cycle  protein polyubiquitination  stimulatory C-type lectin receptor signaling pathway  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  beta-catenin binding  SCF complex assembly  negative regulation of G2/M transition of mitotic cell cycle  Wnt signaling pathway  protein ubiquitination  SCF ubiquitin ligase complex  protein domain specific binding  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  Cul7-RING ubiquitin ligase complex  PcG protein complex  histone H2A monoubiquitination  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  T cell receptor signaling pathway  stress-activated MAPK cascade  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  maintenance of protein location in nucleus  ubiquitin protein ligase activity  extracellular exosome  cullin family protein binding  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  protein polyubiquitination  stimulatory C-type lectin receptor signaling pathway  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  beta-catenin binding  SCF complex assembly  negative regulation of G2/M transition of mitotic cell cycle  Wnt signaling pathway  protein ubiquitination  SCF ubiquitin ligase complex  protein domain specific binding  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  Cul7-RING ubiquitin ligase complex  PcG protein complex  histone H2A monoubiquitination  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  T cell receptor signaling pathway  stress-activated MAPK cascade  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  maintenance of protein location in nucleus  ubiquitin protein ligase activity  extracellular exosome  cullin family protein binding  
Pathways : BIOCARTACyclin E Destruction Pathway [Genes]    Regulation of p27 Phosphorylation during Cell Cycle Progression [Genes]    ER?associated degradation (ERAD) Pathway [Genes]    E2F1 Destruction Pathway [Genes]   
Pathways : KEGG   
NDEx NetworkSKP1
Atlas of Cancer Signalling NetworkSKP1
Wikipedia pathwaysSKP1
Orthology - Evolution
OrthoDB6500
GeneTree (enSembl)ENSG00000113558
Phylogenetic Trees/Animal Genes : TreeFamSKP1
HOVERGENP63208
HOGENOMP63208
Homologs : HomoloGeneSKP1
Homology/Alignments : Family Browser (UCSC)SKP1
Gene fusions - Rearrangements
Fusion : MitelmanSKP1/CDKL3 [5q31.1/5q31.1]  
Fusion : MitelmanVDAC1/SKP1 [5q31.1/5q31.1]  [t(5;5)(q31;q31)]  
Fusion: TCGA_MDACCVDAC1 5q31.1 SKP1 5q31.1 BRCA
Tumor Fusion PortalSKP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSKP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SKP1
dbVarSKP1
ClinVarSKP1
1000_GenomesSKP1 
Exome Variant ServerSKP1
ExAC (Exome Aggregation Consortium)ENSG00000113558
GNOMAD BrowserENSG00000113558
Genetic variants : HAPMAP6500
Genomic Variants (DGV)SKP1 [DGVbeta]
DECIPHERSKP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSKP1 
Mutations
ICGC Data PortalSKP1 
TCGA Data PortalSKP1 
Broad Tumor PortalSKP1
OASIS PortalSKP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSKP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSKP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SKP1
DgiDB (Drug Gene Interaction Database)SKP1
DoCM (Curated mutations)SKP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SKP1 (select a term)
intoGenSKP1
Cancer3DSKP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601434   
Orphanet
DisGeNETSKP1
MedgenSKP1
Genetic Testing Registry SKP1
NextProtP63208 [Medical]
TSGene6500
GENETestsSKP1
Target ValidationSKP1
Huge Navigator SKP1 [HugePedia]
snp3D : Map Gene to Disease6500
BioCentury BCIQSKP1
ClinGenSKP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6500
Chemical/Pharm GKB GenePA162403424
Clinical trialSKP1
Miscellaneous
canSAR (ICR)SKP1 (select the gene name)
Probes
Litterature
PubMed338 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSKP1
EVEXSKP1
GoPubMedSKP1
iHOPSKP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:34:46 CET 2017

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