SKP2 (S-phase kinase associated protein 2)

2003-02-01  

Identity

HGNC
LOCATION
5p13.2
LOCUSID
ALIAS
FBL1,FBXL1,FLB1,p45
FUSION GENES

Other Information

Locus ID:

NCBI: 6502
MIM: 601436
HGNC: 10901
Ensembl: ENSG00000145604

Variants:

dbSNP: 6502
ClinVar: 6502
TCGA: ENSG00000145604
COSMIC: SKP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145604ENST00000274254Q13309
ENSG00000145604ENST00000274255Q13309
ENSG00000145604ENST00000274255A0A024R069
ENSG00000145604ENST00000504386H0Y9I9
ENSG00000145604ENST00000508514D6RAG5
ENSG00000145604ENST00000509692D6RF40
ENSG00000145604ENST00000513151D6R9R7
ENSG00000145604ENST00000513263D6RF40
ENSG00000145604ENST00000546211A0A0A0MTL5
ENSG00000145604ENST00000620197Q13309

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Ubiquitin mediated proteolysisKEGGko04120
mTOR signaling pathwayKEGGko04150
Small cell lung cancerKEGGko05222
Cell cycleKEGGhsa04110
Ubiquitin mediated proteolysisKEGGhsa04120
mTOR signaling pathwayKEGGhsa04150
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
SCF-SKP2 complexKEGGhsa_M00381
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
SCF-SKP2 complexKEGGM00381
FoxO signaling pathwayKEGGhsa04068
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231
G1/S TransitionREACTOMER-HSA-69206
Cyclin E associated events during G1/S transitionREACTOMER-HSA-69202
SCF(Skp2)-mediated degradation of p27/p21REACTOMER-HSA-187577
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1REACTOMER-HSA-174178
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
119615462002Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.546
150145022004Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.189
150145032004Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.185
226329732012The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis.138
192706942009Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.116
192706952009Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.115
129257362003Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.110
124356352002The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).101
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
150965062004Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition.82

Citation

Dessen P

SKP2 (S-phase kinase associated protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42307/skp2