Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SKP2 (S-phase kinase associated protein 2)

Identity

Alias_namesS-phase kinase-associated protein 2 (p45)
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Alias_symbol (synonym)FBXL1
FBL1
p45
Other aliasFLB1
HGNC (Hugo) SKP2
LocusID (NCBI) 6502
Atlas_Id 42307
Location 5p13.2  [Link to chromosome band 5p13]
Location_base_pair Starts at 36152043 and ends at 36184040 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MCAM (11q23.3) / SKP2 (5p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SKP2   10901
Cards
Entrez_Gene (NCBI)SKP2  6502  S-phase kinase associated protein 2
AliasesFBL1; FBXL1; FLB1; p45
GeneCards (Weizmann)SKP2
Ensembl hg19 (Hinxton)ENSG00000145604 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145604 [Gene_View]  chr5:36152043-36184040 [Contig_View]  SKP2 [Vega]
ICGC DataPortalENSG00000145604
TCGA cBioPortalSKP2
AceView (NCBI)SKP2
Genatlas (Paris)SKP2
WikiGenes6502
SOURCE (Princeton)SKP2
Genetics Home Reference (NIH)SKP2
Genomic and cartography
GoldenPath hg38 (UCSC)SKP2  -     chr5:36152043-36184040 +  5p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SKP2  -     5p13.2   [Description]    (hg19-Feb_2009)
EnsemblSKP2 - 5p13.2 [CytoView hg19]  SKP2 - 5p13.2 [CytoView hg38]
Mapping of homologs : NCBISKP2 [Mapview hg19]  SKP2 [Mapview hg38]
OMIM601436   
Gene and transcription
Genbank (Entrez)AB050979 AB050980 AB050981 AK026224 AK291255
RefSeq transcript (Entrez)NM_001243120 NM_005983 NM_032637
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SKP2
Cluster EST : UnigeneHs.23348 [ NCBI ]
CGAP (NCI)Hs.23348
Alternative Splicing GalleryENSG00000145604
Gene ExpressionSKP2 [ NCBI-GEO ]   SKP2 [ EBI - ARRAY_EXPRESS ]   SKP2 [ SEEK ]   SKP2 [ MEM ]
Gene Expression Viewer (FireBrowse)SKP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6502
GTEX Portal (Tissue expression)SKP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13309   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13309  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13309
Splice isoforms : SwissVarQ13309
PhosPhoSitePlusQ13309
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)F-box_dom    L_dom-like    Leu-rich_rpt_Cys-con_subtyp   
Domain families : Pfam (Sanger)F-box-like (PF12937)   
Domain families : Pfam (NCBI)pfam12937   
Domain families : Smart (EMBL)FBOX (SM00256)  LRR_CC (SM00367)  
Conserved Domain (NCBI)SKP2
DMDM Disease mutations6502
Blocks (Seattle)SKP2
PDB (SRS)1FQV    1FS1    1FS2    1LDK    2ASS    2AST   
PDB (PDBSum)1FQV    1FS1    1FS2    1LDK    2ASS    2AST   
PDB (IMB)1FQV    1FS1    1FS2    1LDK    2ASS    2AST   
PDB (RSDB)1FQV    1FS1    1FS2    1LDK    2ASS    2AST   
Structural Biology KnowledgeBase1FQV    1FS1    1FS2    1LDK    2ASS    2AST   
SCOP (Structural Classification of Proteins)1FQV    1FS1    1FS2    1LDK    2ASS    2AST   
CATH (Classification of proteins structures)1FQV    1FS1    1FS2    1LDK    2ASS    2AST   
SuperfamilyQ13309
Human Protein AtlasENSG00000145604
Peptide AtlasQ13309
HPRD03256
IPIIPI00178899   IPI00013294   IPI01012086   IPI00163172   IPI00967750   IPI00968046   IPI00968062   
Protein Interaction databases
DIP (DOE-UCLA)Q13309
IntAct (EBI)Q13309
FunCoupENSG00000145604
BioGRIDSKP2
STRING (EMBL)SKP2
ZODIACSKP2
Ontologies - Pathways
QuickGOQ13309
Ontology : AmiGOG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  cytosol  cell proliferation  protein deubiquitination  SCF ubiquitin ligase complex  anaphase-promoting complex-dependent catabolic process  positive regulation of intracellular estrogen receptor signaling pathway  identical protein binding  regulation of apoptotic process  positive regulation of smooth muscle cell proliferation  ubiquitin protein ligase activity  cellular response to cell-matrix adhesion  positive regulation of protein polyubiquitination  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  cytosol  cell proliferation  protein deubiquitination  SCF ubiquitin ligase complex  anaphase-promoting complex-dependent catabolic process  positive regulation of intracellular estrogen receptor signaling pathway  identical protein binding  regulation of apoptotic process  positive regulation of smooth muscle cell proliferation  ubiquitin protein ligase activity  cellular response to cell-matrix adhesion  positive regulation of protein polyubiquitination  
Pathways : BIOCARTARegulation of p27 Phosphorylation during Cell Cycle Progression [Genes]    Cell Cycle: G1/S Check Point [Genes]    E2F1 Destruction Pathway [Genes]   
Pathways : KEGGFoxO signaling pathway    Cell cycle    Ubiquitin mediated proteolysis    Herpes simplex infection    Epstein-Barr virus infection    Pathways in cancer    Viral carcinogenesis    Small cell lung cancer   
NDEx NetworkSKP2
Atlas of Cancer Signalling NetworkSKP2
Wikipedia pathwaysSKP2
Orthology - Evolution
OrthoDB6502
GeneTree (enSembl)ENSG00000145604
Phylogenetic Trees/Animal Genes : TreeFamSKP2
HOVERGENQ13309
HOGENOMQ13309
Homologs : HomoloGeneSKP2
Homology/Alignments : Family Browser (UCSC)SKP2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSKP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SKP2
dbVarSKP2
ClinVarSKP2
1000_GenomesSKP2 
Exome Variant ServerSKP2
ExAC (Exome Aggregation Consortium)SKP2 (select the gene name)
Genetic variants : HAPMAP6502
Genomic Variants (DGV)SKP2 [DGVbeta]
DECIPHERSKP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSKP2 
Mutations
ICGC Data PortalSKP2 
TCGA Data PortalSKP2 
Broad Tumor PortalSKP2
OASIS PortalSKP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSKP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSKP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SKP2
DgiDB (Drug Gene Interaction Database)SKP2
DoCM (Curated mutations)SKP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SKP2 (select a term)
intoGenSKP2
Cancer3DSKP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601436   
Orphanet
MedgenSKP2
Genetic Testing Registry SKP2
NextProtQ13309 [Medical]
TSGene6502
GENETestsSKP2
Target ValidationSKP2
Huge Navigator SKP2 [HugePedia]
snp3D : Map Gene to Disease6502
BioCentury BCIQSKP2
ClinGenSKP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6502
Chemical/Pharm GKB GenePA35801
Clinical trialSKP2
Miscellaneous
canSAR (ICR)SKP2 (select the gene name)
Probes
Litterature
PubMed388 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSKP2
EVEXSKP2
GoPubMedSKP2
iHOPSKP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:14:35 CEST 2017

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