SLA (Src like adaptor)

2013-07-01  

Identity

HGNC
SLA
LOCATION
8q24.22
LOCUSID
6503
ALIAS
SLA1,SLAP

Other Information

Locus ID:

NCBI: 6503
MIM: 601099
HGNC: 10902
Ensembl: ENSG00000155926

Variants:

dbSNP: 6503
ClinVar: 6503
TCGA: ENSG00000155926
COSMIC: SLA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155926ENST00000338087Q13239
ENSG00000155926ENST00000395352Q13239
ENSG00000155926ENST00000427060Q13239
ENSG00000155926ENST00000517648Q13239
ENSG00000155926ENST00000519341E5RHT2
ENSG00000155926ENST00000519558E5RJB0
ENSG00000155926ENST00000519747E5RK29
ENSG00000155926ENST00000521302E5RGG0
ENSG00000155926ENST00000522119E5RJ69
ENSG00000155926ENST00000522432E5RH80
ENSG00000155926ENST00000523610E5RK95
ENSG00000155926ENST00000524345Q13239

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
242840752014Src-like-adaptor protein (SLAP) differentially regulates normal and oncogenic c-Kit signaling.15
233009352012Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling.14
196319832010Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia.8
227986812012CD3ζ-chain expression of human T lymphocytes is regulated by TNF via Src-like adaptor protein-dependent proteasomal degradation.8
165212182006Characterization of human gene encoding SLA/LP autoantigen and its conserved homologs in mouse, fish, fly, and worm.3
258008722015Intracellular cytoplasm-specific delivery of SH3 and SH2 domains of SLAP inhibits TcR-mediated signaling.2

Citation

Dessen P

SLA (Src like adaptor)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53425/sla