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SLA2 (Src like adaptor 2)

Identity

Alias (NCBI)C20orf156
MARS
SLAP-2
SLAP2
HGNC (Hugo) SLA2
HGNC Alias symbFLJ21992
SLAP-2
HGNC Previous nameC20orf156
HGNC Previous nameSrc-like-adaptor 2
LocusID (NCBI) 84174
Atlas_Id 42308
Location 20q11.23  [Link to chromosome band 20q11]
Location_base_pair Starts at 36612319 and ends at 36646196 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDH4 (20q13.33) / SLA2 (20q11.23)CDH4 20q13.33 / SLA2 20q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SLA2   17329
Cards
Entrez_Gene (NCBI)SLA2    Src like adaptor 2
AliasesC20orf156; MARS; SLAP-2; SLAP2
GeneCards (Weizmann)SLA2
Ensembl hg19 (Hinxton)ENSG00000101082 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101082 [Gene_View]  ENSG00000101082 [Sequence]  chr20:36612319-36646196 [Contig_View]  SLA2 [Vega]
ICGC DataPortalENSG00000101082
TCGA cBioPortalSLA2
AceView (NCBI)SLA2
Genatlas (Paris)SLA2
SOURCE (Princeton)SLA2
Genetics Home Reference (NIH)SLA2
Genomic and cartography
GoldenPath hg38 (UCSC)SLA2  -     chr20:36612319-36646196 -  20q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLA2  -     20q11.23   [Description]    (hg19-Feb_2009)
GoldenPathSLA2 - 20q11.23 [CytoView hg19]  SLA2 - 20q11.23 [CytoView hg38]
ImmunoBaseENSG00000101082
Genome Data Viewer NCBISLA2 [Mapview hg19]  
OMIM606577   
Gene and transcription
Genbank (Entrez)AF290985 AF290986 AF326353 AK025645 AK291513
RefSeq transcript (Entrez)NM_032214 NM_175077
Consensus coding sequences : CCDS (NCBI)SLA2
Gene ExpressionSLA2 [ NCBI-GEO ]   SLA2 [ EBI - ARRAY_EXPRESS ]   SLA2 [ SEEK ]   SLA2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLA2 [ Firebrowse - Broad ]
GenevisibleExpression of SLA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84174
GTEX Portal (Tissue expression)SLA2
Human Protein AtlasENSG00000101082-SLA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H6Q3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H6Q3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H6Q3
PhosPhoSitePlusQ9H6Q3
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)SH2    SH2_dom_sf    SH3-like_dom_sf    SH3_domain    SLAP2    SLAP_SH2   
Domain families : Pfam (Sanger)SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  
Conserved Domain (NCBI)SLA2
PDB (RSDB)4M4Z   
PDB Europe4M4Z   
PDB (PDBSum)4M4Z   
PDB (IMB)4M4Z   
Structural Biology KnowledgeBase4M4Z   
SCOP (Structural Classification of Proteins)4M4Z   
CATH (Classification of proteins structures)4M4Z   
SuperfamilyQ9H6Q3
AlphaFold pdb e-kbQ9H6Q3   
Human Protein Atlas [tissue]ENSG00000101082-SLA2 [tissue]
HPRD05955
Protein Interaction databases
DIP (DOE-UCLA)Q9H6Q3
IntAct (EBI)Q9H6Q3
BioGRIDSLA2
STRING (EMBL)SLA2
ZODIACSLA2
Ontologies - Pathways
QuickGOQ9H6Q3
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  protein binding  nucleoplasm  cytoplasm  late endosome  Golgi apparatus  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex  endosome membrane  cytokine-mediated signaling pathway  B cell mediated immunity  signaling adaptor activity  T cell activation  intracellular membrane-bounded organelle  regulation of phosphatidylinositol 3-kinase activity  phosphatidylinositol phosphate biosynthetic process  1-phosphatidylinositol-3-kinase regulator activity  protein N-terminus binding  regulation of immune response  negative regulation of calcium-mediated signaling  antigen receptor-mediated signaling pathway  negative regulation of T cell receptor signaling pathway  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  protein binding  nucleoplasm  cytoplasm  late endosome  Golgi apparatus  cytosol  plasma membrane  phosphatidylinositol 3-kinase complex  endosome membrane  cytokine-mediated signaling pathway  B cell mediated immunity  signaling adaptor activity  T cell activation  intracellular membrane-bounded organelle  regulation of phosphatidylinositol 3-kinase activity  phosphatidylinositol phosphate biosynthetic process  1-phosphatidylinositol-3-kinase regulator activity  protein N-terminus binding  regulation of immune response  negative regulation of calcium-mediated signaling  antigen receptor-mediated signaling pathway  negative regulation of T cell receptor signaling pathway  
NDEx NetworkSLA2
Atlas of Cancer Signalling NetworkSLA2
Wikipedia pathwaysSLA2
Orthology - Evolution
OrthoDB84174
GeneTree (enSembl)ENSG00000101082
Phylogenetic Trees/Animal Genes : TreeFamSLA2
Homologs : HomoloGeneSLA2
Homology/Alignments : Family Browser (UCSC)SLA2
Gene fusions - Rearrangements
Fusion : MitelmanCDH4/SLA2 [20q13.33/20q11.23]  
Fusion : QuiverSLA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLA2
dbVarSLA2
ClinVarSLA2
MonarchSLA2
1000_GenomesSLA2 
Exome Variant ServerSLA2
GNOMAD BrowserENSG00000101082
Varsome BrowserSLA2
ACMGSLA2 variants
VarityQ9H6Q3
Genomic Variants (DGV)SLA2 [DGVbeta]
DECIPHERSLA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLA2 
Mutations
ICGC Data PortalSLA2 
TCGA Data PortalSLA2 
Broad Tumor PortalSLA2
OASIS PortalSLA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSLA2
Mutations and Diseases : HGMDSLA2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSLA2
DgiDB (Drug Gene Interaction Database)SLA2
DoCM (Curated mutations)SLA2
CIViC (Clinical Interpretations of Variants in Cancer)SLA2
Cancer3DSLA2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606577   
Orphanet
DisGeNETSLA2
MedgenSLA2
Genetic Testing Registry SLA2
NextProtQ9H6Q3 [Medical]
GENETestsSLA2
Target ValidationSLA2
Huge Navigator SLA2 [HugePedia]
ClinGenSLA2
Clinical trials, drugs, therapy
MyCancerGenomeSLA2
Protein Interactions : CTDSLA2
Pharm GKB GenePA38231
PharosQ9H6Q3
Clinical trialSLA2
Miscellaneous
canSAR (ICR)SLA2
HarmonizomeSLA2
DataMed IndexSLA2
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSLA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:31:19 CEST 2021

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