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SLA2 (Src-like-adaptor 2)

Identity

Alias_namesC20orf156
Src-like-adaptor 2
Alias_symbol (synonym)FLJ21992
SLAP-2
Other aliasMARS
SLAP2
HGNC (Hugo) SLA2
LocusID (NCBI) 84174
Atlas_Id 42308
Location 20q11.23  [Link to chromosome band 20q11]
Location_base_pair Starts at 35240924 and ends at 35274619 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDH4 (20q13.33) / SLA2 (20q11.23)CDH4 20q13.33 / SLA2 20q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLA2   17329
Cards
Entrez_Gene (NCBI)SLA2  84174  Src-like-adaptor 2
AliasesC20orf156; MARS; SLAP-2; SLAP2
GeneCards (Weizmann)SLA2
Ensembl hg19 (Hinxton)ENSG00000101082 [Gene_View]  chr20:35240924-35274619 [Contig_View]  SLA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000101082 [Gene_View]  chr20:35240924-35274619 [Contig_View]  SLA2 [Vega]
ICGC DataPortalENSG00000101082
TCGA cBioPortalSLA2
AceView (NCBI)SLA2
Genatlas (Paris)SLA2
WikiGenes84174
SOURCE (Princeton)SLA2
Genetics Home Reference (NIH)SLA2
Genomic and cartography
GoldenPath hg19 (UCSC)SLA2  -     chr20:35240924-35274619 -  20q11.23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SLA2  -     20q11.23   [Description]    (hg38-Dec_2013)
EnsemblSLA2 - 20q11.23 [CytoView hg19]  SLA2 - 20q11.23 [CytoView hg38]
Mapping of homologs : NCBISLA2 [Mapview hg19]  SLA2 [Mapview hg38]
OMIM606577   
Gene and transcription
Genbank (Entrez)AF290985 AF290986 AF326353 AK025645 AK291513
RefSeq transcript (Entrez)NM_032214 NM_175077
RefSeq genomic (Entrez)NC_000020 NC_018931 NG_031823 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)SLA2
Cluster EST : UnigeneHs.713578 [ NCBI ]
CGAP (NCI)Hs.713578
Alternative Splicing GalleryENSG00000101082
Gene ExpressionSLA2 [ NCBI-GEO ]   SLA2 [ EBI - ARRAY_EXPRESS ]   SLA2 [ SEEK ]   SLA2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84174
GTEX Portal (Tissue expression)SLA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H6Q3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H6Q3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H6Q3
Splice isoforms : SwissVarQ9H6Q3
PhosPhoSitePlusQ9H6Q3
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)SH2    SH3_domain   
Domain families : Pfam (Sanger)SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  
Conserved Domain (NCBI)SLA2
DMDM Disease mutations84174
Blocks (Seattle)SLA2
PDB (SRS)4M4Z   
PDB (PDBSum)4M4Z   
PDB (IMB)4M4Z   
PDB (RSDB)4M4Z   
Structural Biology KnowledgeBase4M4Z   
SCOP (Structural Classification of Proteins)4M4Z   
CATH (Classification of proteins structures)4M4Z   
SuperfamilyQ9H6Q3
Human Protein AtlasENSG00000101082
Peptide AtlasQ9H6Q3
HPRD05955
IPIIPI00030447   IPI00103593   IPI00759473   IPI00759606   
Protein Interaction databases
DIP (DOE-UCLA)Q9H6Q3
IntAct (EBI)Q9H6Q3
FunCoupENSG00000101082
BioGRIDSLA2
STRING (EMBL)SLA2
ZODIACSLA2
Ontologies - Pathways
QuickGOQ9H6Q3
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  SH3/SH2 adaptor activity  protein binding  cytoplasm  late endosome  plasma membrane  positive regulation of signal transduction  endosome membrane  cytoplasmic, membrane-bounded vesicle  B cell mediated immunity  intracellular receptor signaling pathway  T cell activation  protein N-terminus binding  regulation of immune response  negative regulation of calcium-mediated signaling  antigen receptor-mediated signaling pathway  negative regulation of B cell activation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  SH3/SH2 adaptor activity  protein binding  cytoplasm  late endosome  plasma membrane  positive regulation of signal transduction  endosome membrane  cytoplasmic, membrane-bounded vesicle  B cell mediated immunity  intracellular receptor signaling pathway  T cell activation  protein N-terminus binding  regulation of immune response  negative regulation of calcium-mediated signaling  antigen receptor-mediated signaling pathway  negative regulation of B cell activation  
NDEx NetworkSLA2
Atlas of Cancer Signalling NetworkSLA2
Wikipedia pathwaysSLA2
Orthology - Evolution
OrthoDB84174
GeneTree (enSembl)ENSG00000101082
Phylogenetic Trees/Animal Genes : TreeFamSLA2
HOVERGENQ9H6Q3
HOGENOMQ9H6Q3
Homologs : HomoloGeneSLA2
Homology/Alignments : Family Browser (UCSC)SLA2
Gene fusions - Rearrangements
Fusion : MitelmanCDH4/SLA2 [20q13.33/20q11.23]  [t(20;20)(q11;q13)]  
Fusion: TCGACDH4 20q13.33 SLA2 20q11.23 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLA2
dbVarSLA2
ClinVarSLA2
1000_GenomesSLA2 
Exome Variant ServerSLA2
ExAC (Exome Aggregation Consortium)SLA2 (select the gene name)
Genetic variants : HAPMAP84174
Genomic Variants (DGV)SLA2 [DGVbeta]
DECIPHER (Syndromes)20:35240924-35274619  ENSG00000101082
CONAN: Copy Number AnalysisSLA2 
Mutations
ICGC Data PortalSLA2 
TCGA Data PortalSLA2 
Broad Tumor PortalSLA2
OASIS PortalSLA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLA2
DgiDB (Drug Gene Interaction Database)SLA2
DoCM (Curated mutations)SLA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLA2 (select a term)
intoGenSLA2
Cancer3DSLA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606577   
Orphanet
MedgenSLA2
Genetic Testing Registry SLA2
NextProtQ9H6Q3 [Medical]
TSGene84174
GENETestsSLA2
Huge Navigator SLA2 [HugePedia]
snp3D : Map Gene to Disease84174
BioCentury BCIQSLA2
ClinGenSLA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84174
Chemical/Pharm GKB GenePA38231
Clinical trialSLA2
Miscellaneous
canSAR (ICR)SLA2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLA2
EVEXSLA2
GoPubMedSLA2
iHOPSLA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:19:26 CEST 2017

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