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SLAMF1 (signaling lymphocytic activation molecule family member 1)

Identity

Alias_namesSLAM
signaling lymphocytic activation molecule
Alias_symbol (synonym)CD150
Other aliasCDw150
HGNC (Hugo) SLAMF1
LocusID (NCBI) 6504
Atlas_Id 42309
Location 1q23.3  [Link to chromosome band 1q23]
Location_base_pair Starts at 160608100 and ends at 160647311 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
APH1A (1q21.2) / SLAMF1 (1q23.3)SLAMF1 (1q23.3) / CD1A (1q23.1)SLAMF1 (1q23.3) / CD1C (1q23.1)
SLAMF1 (1q23.3) / KIF26B (1q44)APH1A 1q21.2 / SLAMF1 1q23.3SLAMF1 1q23.3 / CD1A 1q23.1
SLAMF1 1q23.3 / CD1C 1q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLAMF1   10903
Cards
Entrez_Gene (NCBI)SLAMF1  6504  signaling lymphocytic activation molecule family member 1
AliasesCD150; CDw150; SLAM
GeneCards (Weizmann)SLAMF1
Ensembl hg19 (Hinxton)ENSG00000117090 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117090 [Gene_View]  chr1:160608100-160647311 [Contig_View]  SLAMF1 [Vega]
ICGC DataPortalENSG00000117090
TCGA cBioPortalSLAMF1
AceView (NCBI)SLAMF1
Genatlas (Paris)SLAMF1
WikiGenes6504
SOURCE (Princeton)SLAMF1
Genetics Home Reference (NIH)SLAMF1
Genomic and cartography
GoldenPath hg38 (UCSC)SLAMF1  -     chr1:160608100-160647311 -  1q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLAMF1  -     1q23.3   [Description]    (hg19-Feb_2009)
EnsemblSLAMF1 - 1q23.3 [CytoView hg19]  SLAMF1 - 1q23.3 [CytoView hg38]
Mapping of homologs : NCBISLAMF1 [Mapview hg19]  SLAMF1 [Mapview hg38]
OMIM603492   
Gene and transcription
Genbank (Entrez)AA825199 AK304237 AK311666 AK314244 AY040554
RefSeq transcript (Entrez)NM_001330754 NM_003037
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLAMF1
Cluster EST : UnigeneHs.523660 [ NCBI ]
CGAP (NCI)Hs.523660
Alternative Splicing GalleryENSG00000117090
Gene ExpressionSLAMF1 [ NCBI-GEO ]   SLAMF1 [ EBI - ARRAY_EXPRESS ]   SLAMF1 [ SEEK ]   SLAMF1 [ MEM ]
Gene Expression Viewer (FireBrowse)SLAMF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6504
GTEX Portal (Tissue expression)SLAMF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13291   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13291  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13291
Splice isoforms : SwissVarQ13291
PhosPhoSitePlusQ13291
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Sig_lymph_act_molc_N   
Domain families : Pfam (Sanger)SLAM (PF06214)   
Domain families : Pfam (NCBI)pfam06214   
Domain structure : Prodom (Prabi Lyon)Sig_lymph_act_molc_N (PD090491)   
Conserved Domain (NCBI)SLAMF1
DMDM Disease mutations6504
Blocks (Seattle)SLAMF1
PDB (SRS)1D4T    1D4W    1I3Z    1KA6    1KA7    1M27    2DZF    2IE9    2IFL    2IG5   
PDB (PDBSum)1D4T    1D4W    1I3Z    1KA6    1KA7    1M27    2DZF    2IE9    2IFL    2IG5   
PDB (IMB)1D4T    1D4W    1I3Z    1KA6    1KA7    1M27    2DZF    2IE9    2IFL    2IG5   
PDB (RSDB)1D4T    1D4W    1I3Z    1KA6    1KA7    1M27    2DZF    2IE9    2IFL    2IG5   
Structural Biology KnowledgeBase1D4T    1D4W    1I3Z    1KA6    1KA7    1M27    2DZF    2IE9    2IFL    2IG5   
SCOP (Structural Classification of Proteins)1D4T    1D4W    1I3Z    1KA6    1KA7    1M27    2DZF    2IE9    2IFL    2IG5   
CATH (Classification of proteins structures)1D4T    1D4W    1I3Z    1KA6    1KA7    1M27    2DZF    2IE9    2IFL    2IG5   
SuperfamilyQ13291
Human Protein AtlasENSG00000117090
Peptide AtlasQ13291
HPRD04603
IPIIPI00012469   IPI00374060   IPI00220229   IPI01014155   IPI00979800   IPI00749169   
Protein Interaction databases
DIP (DOE-UCLA)Q13291
IntAct (EBI)Q13291
FunCoupENSG00000117090
BioGRIDSLAMF1
STRING (EMBL)SLAMF1
ZODIACSLAMF1
Ontologies - Pathways
QuickGOQ13291
Ontology : AmiGOvirus receptor activity  natural killer cell differentiation  natural killer cell proliferation  leukocyte chemotaxis involved in inflammatory response  myeloid dendritic cell activation involved in immune response  negative regulation of T cell cytokine production  antigen binding  transmembrane signaling receptor activity  protein binding  phagocytosis  cell adhesion  signal transduction  positive regulation of cell proliferation  external side of plasma membrane  positive regulation of macrophage chemotaxis  integral component of membrane  regulation of vesicle fusion  negative regulation of interleukin-12 production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  T-helper 1 cell cytokine production  positive regulation of activated T cell proliferation  identical protein binding  innate immune response  phagocytic vesicle  positive regulation of JNK cascade  viral entry into host cell  regulation of catalytic activity  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  negative regulation of interferon-gamma secretion  positive regulation of interferon-gamma secretion  negative regulation of CD40 signaling pathway  positive regulation of dendritic cell chemotaxis  
Ontology : EGO-EBIvirus receptor activity  natural killer cell differentiation  natural killer cell proliferation  leukocyte chemotaxis involved in inflammatory response  myeloid dendritic cell activation involved in immune response  negative regulation of T cell cytokine production  antigen binding  transmembrane signaling receptor activity  protein binding  phagocytosis  cell adhesion  signal transduction  positive regulation of cell proliferation  external side of plasma membrane  positive regulation of macrophage chemotaxis  integral component of membrane  regulation of vesicle fusion  negative regulation of interleukin-12 production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  T-helper 1 cell cytokine production  positive regulation of activated T cell proliferation  identical protein binding  innate immune response  phagocytic vesicle  positive regulation of JNK cascade  viral entry into host cell  regulation of catalytic activity  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  negative regulation of interferon-gamma secretion  positive regulation of interferon-gamma secretion  negative regulation of CD40 signaling pathway  positive regulation of dendritic cell chemotaxis  
Pathways : KEGGMeasles   
NDEx NetworkSLAMF1
Atlas of Cancer Signalling NetworkSLAMF1
Wikipedia pathwaysSLAMF1
Orthology - Evolution
OrthoDB6504
GeneTree (enSembl)ENSG00000117090
Phylogenetic Trees/Animal Genes : TreeFamSLAMF1
HOVERGENQ13291
HOGENOMQ13291
Homologs : HomoloGeneSLAMF1
Homology/Alignments : Family Browser (UCSC)SLAMF1
Gene fusions - Rearrangements
Fusion : MitelmanAPH1A/SLAMF1 [1q21.2/1q23.3]  [t(1;1)(q21;q23)]  
Fusion : MitelmanSLAMF1/CD1A [1q23.3/1q23.1]  [t(1;1)(q23;q23)]  
Fusion : MitelmanSLAMF1/CD1C [1q23.3/1q23.1]  [t(1;1)(q23;q23)]  
Fusion: TCGAAPH1A 1q21.2 SLAMF1 1q23.3 LUAD
Fusion: TCGASLAMF1 1q23.3 CD1A 1q23.1 LUAD THCA
Fusion: TCGASLAMF1 1q23.3 CD1C 1q23.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLAMF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLAMF1
dbVarSLAMF1
ClinVarSLAMF1
1000_GenomesSLAMF1 
Exome Variant ServerSLAMF1
ExAC (Exome Aggregation Consortium)SLAMF1 (select the gene name)
Genetic variants : HAPMAP6504
Genomic Variants (DGV)SLAMF1 [DGVbeta]
DECIPHERSLAMF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLAMF1 
Mutations
ICGC Data PortalSLAMF1 
TCGA Data PortalSLAMF1 
Broad Tumor PortalSLAMF1
OASIS PortalSLAMF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLAMF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLAMF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch SLAMF1
DgiDB (Drug Gene Interaction Database)SLAMF1
DoCM (Curated mutations)SLAMF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLAMF1 (select a term)
intoGenSLAMF1
Cancer3DSLAMF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603492   
Orphanet
MedgenSLAMF1
Genetic Testing Registry SLAMF1
NextProtQ13291 [Medical]
TSGene6504
GENETestsSLAMF1
Huge Navigator SLAMF1 [HugePedia]
snp3D : Map Gene to Disease6504
BioCentury BCIQSLAMF1
ClinGenSLAMF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6504
Chemical/Pharm GKB GenePA35803
Clinical trialSLAMF1
Miscellaneous
canSAR (ICR)SLAMF1 (select the gene name)
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLAMF1
EVEXSLAMF1
GoPubMedSLAMF1
iHOPSLAMF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:37:21 CEST 2017

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