SLAMF7 (SLAM family member 7)

2016-08-01  

Identity

HGNC
SLAMF7
LOCATION
1q23.3
LOCUSID
57823
ALIAS
19A,CD319,CRACC,CS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57823
MIM: 606625
HGNC: 21394
Ensembl: ENSG00000026751

Variants:

dbSNP: 57823
ClinVar: 57823
TCGA: ENSG00000026751
COSMIC: SLAMF7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000026751ENST00000359331Q9NQ25
ENSG00000026751ENST00000368042Q9NQ25
ENSG00000026751ENST00000368043Q9NQ25
ENSG00000026751ENST00000441662Q9NQ25
ENSG00000026751ENST00000444090Q9NQ25
ENSG00000026751ENST00000458104B4DVL7
ENSG00000026751ENST00000458602Q9NQ25
ENSG00000026751ENST00000495334R4GND0
ENSG00000026751ENST00000621377B4DW98

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
184512452008CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma.140
179060762008Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu.139
284245162017SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin.35
182168652008Association of LY9 in UK and Canadian SLE families.30
203459772010Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythematosus.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
178783652007CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes.23
199047672010Activating NK-cell receptors co-stimulate CD4(+)CD28(-) T cells in patients with rheumatoid arthritis.21
253126472015Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells.21
179816032008Regulation of NK cell activity by 2B4, NTB-A and CRACC.17

Citation

Dessen P

SLAMF7 (SLAM family member 7)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55902/slamf7