SLBP (stem-loop binding protein)

2015-02-01  

Identity

HGNC
LOCATION
4p16.3
LOCUSID
ALIAS
HBP
FUSION GENES

Other Information

Locus ID:

NCBI: 7884
MIM: 602422
HGNC: 10904
Ensembl: ENSG00000163950

Variants:

dbSNP: 7884
ClinVar: 7884
TCGA: ENSG00000163950
COSMIC: SLBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163950ENST00000318386F8W8D3
ENSG00000163950ENST00000429429Q14493
ENSG00000163950ENST00000480936H7C4H8
ENSG00000163950ENST00000483348H0YAE8
ENSG00000163950ENST00000488267E7EUV9
ENSG00000163950ENST00000489418Q14493
ENSG00000163950ENST00000489418Q53XR2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNAs Derived from Intronless TranscriptsREACTOMER-HSA-159234
Transport of the SLBP Dependant Mature mRNAREACTOMER-HSA-159230
Processing of Capped Intronless Pre-mRNAREACTOMER-HSA-75067
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAsREACTOMER-HSA-77588

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
174990422007NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.100
125889792003Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase.53
233290462013Structure of histone mRNA stem-loop, human stem-loop binding protein, and 3'hExo ternary complex.47
191553252009Knockdown of SLBP results in nuclear retention of histone mRNA.41
155469202004The human histone gene expression regulator HBP/SLBP is required for histone and DNA synthesis, cell cycle progression and cell proliferation in mitotic cells.34
184904412008Phosphorylation of threonine 61 by cyclin a/Cdk1 triggers degradation of stem-loop binding protein at the end of S phase.34
169318772006Genome-wide analysis of mRNAs bound to the histone stem-loop binding protein.32
180251072008SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein.31
229077572012The prolyl isomerase Pin1 targets stem-loop binding protein (SLBP) to dissociate the SLBP-histone mRNA complex linking histone mRNA decay with SLBP ubiquitination.27
277736722016Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2.23

Citation

Dessen P

SLBP (stem-loop binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54997/slbp