Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SLC11A1 (solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1)

Identity

Other namesLSH
NRAMP
NRAMP1
HGNC (Hugo) SLC11A1
LocusID (NCBI) 6556
Location 2q35
Location_base_pair Starts at 219246752 and ends at 219261617 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SLC11A1   10907
Cards
Entrez_Gene (NCBI)SLC11A1  6556  solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
GeneCards (Weizmann)SLC11A1
Ensembl (Hinxton)ENSG00000018280 [Gene_View]  chr2:219246752-219261617 [Contig_View]  SLC11A1 [Vega]
ICGC DataPortalENSG00000018280
cBioPortalSLC11A1
AceView (NCBI)SLC11A1
Genatlas (Paris)SLC11A1
WikiGenes6556
SOURCE (Princeton)NM_000578 NM_001032220
Genomic and cartography
GoldenPath (UCSC)SLC11A1  -  2q35   chr2:219246752-219261617 +  2q35   [Description]    (hg19-Feb_2009)
EnsemblSLC11A1 - 2q35 [CytoView]
Mapping of homologs : NCBISLC11A1 [Mapview]
OMIM600266   607948   610446   
Gene and transcription
Genbank (Entrez)AB209650 AK294707 AK298667 AK303398 AK307954
RefSeq transcript (Entrez)NM_000578 NM_001032220
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_012128 NT_005403 NW_001838865 NW_004929305
Consensus coding sequences : CCDS (NCBI)SLC11A1
Cluster EST : UnigeneHs.591607 [ NCBI ]
CGAP (NCI)Hs.591607
Alternative Splicing : Fast-db (Paris)GSHG0017191
Alternative Splicing GalleryENSG00000018280
Gene ExpressionSLC11A1 [ NCBI-GEO ]     SLC11A1 [ SEEK ]   SLC11A1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49279 (Uniprot)
NextProtP49279  [Medical]
With graphics : InterProP49279
Splice isoforms : SwissVarP49279 (Swissvar)
Domains : Interpro (EBI)NRAMP-like [organisation]  
Related proteins : CluSTrP49279
Domain families : Pfam (Sanger)Nramp (PF01566)   
Domain families : Pfam (NCBI)pfam01566   
DMDM Disease mutations6556
Blocks (Seattle)P49279
Human Protein AtlasENSG00000018280 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP49279
HPRD02601
IPIIPI00290432   IPI00795372   IPI01012781   IPI01018119   
Protein Interaction databases
DIP (DOE-UCLA)P49279
IntAct (EBI)P49279
FunCoupENSG00000018280
BioGRIDSLC11A1
InParanoidP49279
Interologous Interaction database P49279
IntegromeDBSLC11A1
STRING (EMBL)SLC11A1
Ontologies - Pathways
Ontology : AmiGOprotein import into nucleus, translocation  negative regulation of cytokine production  positive regulation of cytokine production  T cell proliferation involved in immune response  T cell cytokine production  positive regulation of dendritic cell antigen processing and presentation  positive regulation of T-helper 1 type immune response  manganese ion transmembrane transporter activity  lysosome  late endosome  plasma membrane  integral component of plasma membrane  iron ion transport  manganese ion transport  cellular cadmium ion homeostasis  cellular iron ion homeostasis  phagocytosis  inflammatory response  vacuolar acidification  cell outer membrane  response to bacterium  positive regulation of gene expression  nitrite transport  phagocytic vesicle membrane  late endosome membrane  activation of protein kinase activity  response to lipopolysaccharide  interleukin-2 production  interleukin-3 production  positive regulation of interferon-gamma production  response to interferon-gamma  wound healing  macrophage activation  defense response to bacterium  protein homodimerization activity  defense response to protozoan  L-arginine import  MHC class II biosynthetic process  respiratory burst  positive regulation of transcription from RNA polymerase II promoter  transition metal ion transmembrane transporter activity  antigen processing and presentation of peptide antigen  mRNA stabilization  positive regulation of phagocytosis  defense response to Gram-negative bacterium  metal ion:proton antiporter activity  interaction with host  iron ion homeostasis  transmembrane transport  multicellular organismal iron ion homeostasis  cadmium ion transmembrane transport  tertiary granule membrane  divalent metal ion export  manganese ion transmembrane transport  phagosome maturation  
Ontology : EGO-EBIprotein import into nucleus, translocation  negative regulation of cytokine production  positive regulation of cytokine production  T cell proliferation involved in immune response  T cell cytokine production  positive regulation of dendritic cell antigen processing and presentation  positive regulation of T-helper 1 type immune response  manganese ion transmembrane transporter activity  lysosome  late endosome  plasma membrane  integral component of plasma membrane  iron ion transport  manganese ion transport  cellular cadmium ion homeostasis  cellular iron ion homeostasis  phagocytosis  inflammatory response  vacuolar acidification  cell outer membrane  response to bacterium  positive regulation of gene expression  nitrite transport  phagocytic vesicle membrane  late endosome membrane  activation of protein kinase activity  response to lipopolysaccharide  interleukin-2 production  interleukin-3 production  positive regulation of interferon-gamma production  response to interferon-gamma  wound healing  macrophage activation  defense response to bacterium  protein homodimerization activity  defense response to protozoan  L-arginine import  MHC class II biosynthetic process  respiratory burst  positive regulation of transcription from RNA polymerase II promoter  transition metal ion transmembrane transporter activity  antigen processing and presentation of peptide antigen  mRNA stabilization  positive regulation of phagocytosis  defense response to Gram-negative bacterium  metal ion:proton antiporter activity  interaction with host  iron ion homeostasis  transmembrane transport  multicellular organismal iron ion homeostasis  cadmium ion transmembrane transport  tertiary granule membrane  divalent metal ion export  manganese ion transmembrane transport  phagosome maturation  
Pathways : KEGGLysosome    Mineral absorption   
Protein Interaction DatabaseSLC11A1
Wikipedia pathwaysSLC11A1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SLC11A1
snp3D : Map Gene to Disease6556
SNP (GeneSNP Utah)SLC11A1
SNP : HGBaseSLC11A1
Genetic variants : HAPMAPSLC11A1
Exome VariantSLC11A1
1000_GenomesSLC11A1 
ICGC programENSG00000018280 
Somatic Mutations in Cancer : COSMICSLC11A1 
CONAN: Copy Number AnalysisSLC11A1 
Mutations and Diseases : HGMDSLC11A1
Mutations and Diseases : intOGenSLC11A1
Genomic VariantsSLC11A1  SLC11A1 [DGVbeta]
dbVarSLC11A1
ClinVarSLC11A1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM600266    607948    610446   
MedgenSLC11A1
GENETestsSLC11A1
Disease Genetic AssociationSLC11A1
Huge Navigator SLC11A1 [HugePedia]  SLC11A1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneSLC11A1
Homology/Alignments : Family Browser (UCSC)SLC11A1
Phylogenetic Trees/Animal Genes : TreeFamSLC11A1
Chemical/Protein Interactions : CTD6556
Chemical/Pharm GKB GenePA319
Clinical trialSLC11A1
Cancer Resource (Charite)ENSG00000018280
Other databases
Probes
Litterature
PubMed154 Pubmed reference(s) in Entrez
CoreMineSLC11A1
iHOPSLC11A1
OncoSearchSLC11A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:04:48 CEST 2014

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