SLC11A1 (solute carrier family 11 member 1)

2007-02-01  

Identity

HGNC
LOCATION
2q35
LOCUSID
ALIAS
LSH,NRAMP,NRAMP1
FUSION GENES

Other Information

Locus ID:

NCBI: 6556
MIM: 600266
HGNC: 10907
Ensembl: ENSG00000018280

Variants:

dbSNP: 6556
ClinVar: 6556
TCGA: ENSG00000018280
COSMIC: SLC11A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000018280ENST00000233202P49279
ENSG00000018280ENST00000233202A0A024R474
ENSG00000018280ENST00000354352Q9HBK0
ENSG00000018280ENST00000473367A0A087X2D6
ENSG00000018280ENST00000481524A0A087X181
ENSG00000018280ENST00000539932A0A0A0MTL3

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
ROS, RNS production in phagocytesREACTOMER-HSA-1222556
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Antimicrobial peptidesREACTOMER-HSA-6803157
Ion influx/efflux at host-pathogen interfaceREACTOMER-HSA-6803544
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
124041622002Ethnic-specific genetic associations with pulmonary tuberculosis.69
153818172004Large-scale candidate gene study of tuberculosis susceptibility in the Karonga district of northern Malawi.47
124477672002Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis.45
125272282003Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story.40
164660302006SLC11A1 (formerly NRAMP1) gene polymorphisms and tuberculosis susceptibility: a meta-analysis.39
161033552005Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease.37
212835672011SLC11A1 (NRAMP1) polymorphisms and tuberculosis susceptibility: updated systematic review and meta-analysis.36
260557222015Nramp1 and Other Transporters Involved in Metal Withholding during Infection.36
151417342004VDR and NRAMP1 gene polymorphisms in susceptibility to pulmonary tuberculosis among the Chinese Han population: a case-control study.35

Citation

Dessen P

SLC11A1 (solute carrier family 11 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45643/slc11a1