Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SLC11A2 (solute carrier family 11 member 2)

Identity

Alias_namesNRAMP2
solute carrier family 11 (proton-coupled divalent metal ion transporter)
Alias_symbol (synonym)DCT1
DMT1
Other aliasAHMIO1
HGNC (Hugo) SLC11A2
LocusID (NCBI) 4891
Atlas_Id 53798
Location 12q13.12  [Link to chromosome band 12q13]
Location_base_pair Starts at 51379775 and ends at 51420199 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PCDH10 (4q28.3) / SLC11A2 (12q13.12)SLC11A2 (12q13.12) / MCM3 (6p12.2)SLC11A2 (12q13.12) / PFKM (12q13.11)
SLC11A2 12q13.12 / PFKM 12q13.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC11A2   10908
Cards
Entrez_Gene (NCBI)SLC11A2  4891  solute carrier family 11 member 2
AliasesAHMIO1; DCT1; DMT1; NRAMP2
GeneCards (Weizmann)SLC11A2
Ensembl hg19 (Hinxton)ENSG00000110911 [Gene_View]  chr12:51379775-51420199 [Contig_View]  SLC11A2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000110911 [Gene_View]  chr12:51379775-51420199 [Contig_View]  SLC11A2 [Vega]
ICGC DataPortalENSG00000110911
TCGA cBioPortalSLC11A2
AceView (NCBI)SLC11A2
Genatlas (Paris)SLC11A2
WikiGenes4891
SOURCE (Princeton)SLC11A2
Genetics Home Reference (NIH)SLC11A2
Genomic and cartography
GoldenPath hg19 (UCSC)SLC11A2  -     chr12:51379775-51420199 -  12q13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SLC11A2  -     12q13.12   [Description]    (hg38-Dec_2013)
EnsemblSLC11A2 - 12q13.12 [CytoView hg19]  SLC11A2 - 12q13.12 [CytoView hg38]
Mapping of homologs : NCBISLC11A2 [Mapview hg19]  SLC11A2 [Mapview hg38]
OMIM206100   600523   
Gene and transcription
Genbank (Entrez)AB004857 AB062284 AF046997 AF064484 AJ493662
RefSeq transcript (Entrez)NM_000617 NM_001174125 NM_001174126 NM_001174127 NM_001174128 NM_001174129 NM_001174130
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_021139 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)SLC11A2
Cluster EST : UnigeneHs.505545 [ NCBI ]
CGAP (NCI)Hs.505545
Alternative Splicing GalleryENSG00000110911
Gene ExpressionSLC11A2 [ NCBI-GEO ]   SLC11A2 [ EBI - ARRAY_EXPRESS ]   SLC11A2 [ SEEK ]   SLC11A2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC11A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4891
GTEX Portal (Tissue expression)SLC11A2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49281   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49281  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49281
Splice isoforms : SwissVarP49281
PhosPhoSitePlusP49281
Domains : Interpro (EBI)NRAMP_fam   
Domain families : Pfam (Sanger)Nramp (PF01566)   
Domain families : Pfam (NCBI)pfam01566   
Conserved Domain (NCBI)SLC11A2
DMDM Disease mutations4891
Blocks (Seattle)SLC11A2
SuperfamilyP49281
Human Protein AtlasENSG00000110911
Peptide AtlasP49281
HPRD02750
IPIIPI00465037   IPI00394753   IPI00795148   IPI00944520   IPI01022754   IPI01022419   IPI01021085   IPI01020936   IPI01020804   IPI01023073   IPI01021954   IPI01021804   IPI01022705   IPI01022395   IPI01022243   IPI00793358   
Protein Interaction databases
DIP (DOE-UCLA)P49281
IntAct (EBI)P49281
FunCoupENSG00000110911
BioGRIDSLC11A2
STRING (EMBL)SLC11A2
ZODIACSLC11A2
Ontologies - Pathways
QuickGOP49281
Ontology : AmiGOresponse to hypoxia  detection of oxygen  detection of oxygen  copper ion transmembrane transporter activity  iron ion transmembrane transporter activity  manganese ion transmembrane transporter activity  zinc ion transmembrane transporter activity  zinc ion transmembrane transporter activity  protein binding  nucleus  cytoplasm  mitochondrial outer membrane  lysosome  lysosomal membrane  early endosome  late endosome  vacuole  trans-Golgi network  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  heme biosynthetic process  cobalt ion transport  cobalt ion transport  copper ion transport  manganese ion transport  cellular iron ion homeostasis  activation of cysteine-type endopeptidase activity involved in apoptotic process  learning or memory  cell surface  cell surface  response to iron ion  response to iron ion  hydrogen ion transmembrane transporter activity  calcium ion transmembrane transporter activity  cadmium ion transmembrane transporter activity  cobalt ion transmembrane transporter activity  cobalt ion transmembrane transporter activity  ferrous iron transmembrane transporter activity  lead ion transmembrane transporter activity  nickel cation transmembrane transporter activity  vanadium ion transmembrane transporter activity  solute:proton symporter activity  ferrous iron uptake transmembrane transporter activity  nickel cation transport  vanadium ion transport  ferrous iron transport  lead ion transport  membrane  apical plasma membrane  inorganic cation transmembrane transporter activity  retromer complex  cytoplasmic vesicle  brush border membrane  late endosome membrane  transferrin transmembrane transporter activity  transferrin transport  cellular response to oxidative stress  iron ion transmembrane transport  copper ion transmembrane transport  nickel cation transmembrane transport  apical part of cell  basal part of cell  cadmium ion binding  transition metal ion transmembrane transporter activity  perinuclear region of cytoplasm  dendrite morphogenesis  erythrocyte development  recycling endosome  multicellular organismal iron ion homeostasis  cadmium ion transmembrane transport  ferrous iron import  ferrous iron import  paraferritin complex  chromium ion transmembrane transporter activity  manganese ion transmembrane transport  zinc II ion transmembrane transport  cation transmembrane transport  hydrogen ion transmembrane transport  ferrous iron transmembrane transport  ferrous iron transmembrane transport  ferrous iron transmembrane transport  
Ontology : EGO-EBIresponse to hypoxia  detection of oxygen  detection of oxygen  copper ion transmembrane transporter activity  iron ion transmembrane transporter activity  manganese ion transmembrane transporter activity  zinc ion transmembrane transporter activity  zinc ion transmembrane transporter activity  protein binding  nucleus  cytoplasm  mitochondrial outer membrane  lysosome  lysosomal membrane  early endosome  late endosome  vacuole  trans-Golgi network  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  heme biosynthetic process  cobalt ion transport  cobalt ion transport  copper ion transport  manganese ion transport  cellular iron ion homeostasis  activation of cysteine-type endopeptidase activity involved in apoptotic process  learning or memory  cell surface  cell surface  response to iron ion  response to iron ion  hydrogen ion transmembrane transporter activity  calcium ion transmembrane transporter activity  cadmium ion transmembrane transporter activity  cobalt ion transmembrane transporter activity  cobalt ion transmembrane transporter activity  ferrous iron transmembrane transporter activity  lead ion transmembrane transporter activity  nickel cation transmembrane transporter activity  vanadium ion transmembrane transporter activity  solute:proton symporter activity  ferrous iron uptake transmembrane transporter activity  nickel cation transport  vanadium ion transport  ferrous iron transport  lead ion transport  membrane  apical plasma membrane  inorganic cation transmembrane transporter activity  retromer complex  cytoplasmic vesicle  brush border membrane  late endosome membrane  transferrin transmembrane transporter activity  transferrin transport  cellular response to oxidative stress  iron ion transmembrane transport  copper ion transmembrane transport  nickel cation transmembrane transport  apical part of cell  basal part of cell  cadmium ion binding  transition metal ion transmembrane transporter activity  perinuclear region of cytoplasm  dendrite morphogenesis  erythrocyte development  recycling endosome  multicellular organismal iron ion homeostasis  cadmium ion transmembrane transport  ferrous iron import  ferrous iron import  paraferritin complex  chromium ion transmembrane transporter activity  manganese ion transmembrane transport  zinc II ion transmembrane transport  cation transmembrane transport  hydrogen ion transmembrane transport  ferrous iron transmembrane transport  ferrous iron transmembrane transport  ferrous iron transmembrane transport  
Pathways : KEGGLysosome    Mineral absorption   
NDEx NetworkSLC11A2
Atlas of Cancer Signalling NetworkSLC11A2
Wikipedia pathwaysSLC11A2
Orthology - Evolution
OrthoDB4891
GeneTree (enSembl)ENSG00000110911
Phylogenetic Trees/Animal Genes : TreeFamSLC11A2
HOVERGENP49281
HOGENOMP49281
Homologs : HomoloGeneSLC11A2
Homology/Alignments : Family Browser (UCSC)SLC11A2
Gene fusions - Rearrangements
Fusion : MitelmanSLC11A2/PFKM [12q13.12/12q13.11]  
Fusion: TCGASLC11A2 12q13.12 PFKM 12q13.11 GBM
Fusion Cancer (Beijing)SLC11A2 [12q13.12]  -  MCM3 [6p12.2]  [FUSC000333]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC11A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC11A2
dbVarSLC11A2
ClinVarSLC11A2
1000_GenomesSLC11A2 
Exome Variant ServerSLC11A2
ExAC (Exome Aggregation Consortium)SLC11A2 (select the gene name)
Genetic variants : HAPMAP4891
Genomic Variants (DGV)SLC11A2 [DGVbeta]
DECIPHER (Syndromes)12:51379775-51420199  ENSG00000110911
CONAN: Copy Number AnalysisSLC11A2 
Mutations
ICGC Data PortalSLC11A2 
TCGA Data PortalSLC11A2 
Broad Tumor PortalSLC11A2
OASIS PortalSLC11A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC11A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC11A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC11A2
DgiDB (Drug Gene Interaction Database)SLC11A2
DoCM (Curated mutations)SLC11A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC11A2 (select a term)
intoGenSLC11A2
Cancer3DSLC11A2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM206100    600523   
Orphanet11602   
MedgenSLC11A2
Genetic Testing Registry SLC11A2
NextProtP49281 [Medical]
TSGene4891
GENETestsSLC11A2
Huge Navigator SLC11A2 [HugePedia]
snp3D : Map Gene to Disease4891
BioCentury BCIQSLC11A2
ClinGenSLC11A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4891
Chemical/Pharm GKB GenePA259
Clinical trialSLC11A2
Miscellaneous
canSAR (ICR)SLC11A2 (select the gene name)
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC11A2
EVEXSLC11A2
GoPubMedSLC11A2
iHOPSLC11A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:27:28 CET 2017

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