SLC12A7 (solute carrier family 12 member 7)

2007-02-01  

Identity

HGNC
LOCATION
5p15.33
LOCUSID
ALIAS
KCC4
FUSION GENES

Other Information

Locus ID:

NCBI: 10723
MIM: 604879
HGNC: 10915
Ensembl: ENSG00000113504

Variants:

dbSNP: 10723
ClinVar: 10723
TCGA: ENSG00000113504
COSMIC: SLC12A7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113504ENST00000264930Q9Y666
ENSG00000113504ENST00000504576A0A0U1RR10
ENSG00000113504ENST00000513223H0YB78
ENSG00000113504ENST00000634447A0A0U1RR18

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Collecting duct acid secretionKEGGko04966
Collecting duct acid secretionKEGGhsa04966
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Cation-coupled Chloride cotransportersREACTOMER-HSA-426117

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
119766892002Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4.106
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
152629972004Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.24
198876032009Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion.15
205160682010Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4.14
171333542007IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness.13
189845872009Functional association between K+-Cl- cotransporter-4 and H+,K+-ATPase in the apical canalicular membrane of gastric parietal cells.12
216136062011Similar effects of all WNK3 variants on SLC12 cotransporters.11
217338502011K-Cl cotransporter gene expression during human and murine erythroid differentiation.8
217609192011Frog oocytes to unveil the structure and supramolecular organization of human transport proteins.5

Citation

Dessen P

SLC12A7 (solute carrier family 12 member 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46549/slc12a7