SLC13A3 (solute carrier family 13 member 3)

2014-11-01  

Identity

HGNC
LOCATION
20q13.12
LOCUSID
ALIAS
ARLIAK,NADC3,SDCT2
FUSION GENES

Other Information

Locus ID:

NCBI: 64849
MIM: 606411
HGNC: 14430
Ensembl: ENSG00000158296

Variants:

dbSNP: 64849
ClinVar: 64849
TCGA: ENSG00000158296
COSMIC: SLC13A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158296ENST00000279027Q8WWT9
ENSG00000158296ENST00000290317Q8WWT9
ENSG00000158296ENST00000372121A0A0A0MRQ6
ENSG00000158296ENST00000413164Q8WWT9
ENSG00000158296ENST00000417157C9J4A3
ENSG00000158296ENST00000420568X6RDV4
ENSG00000158296ENST00000450298H7C0C8
ENSG00000158296ENST00000468915C9J7L4
ENSG00000158296ENST00000472148Q8WWT9
ENSG00000158296ENST00000495082Q8WWT9

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Sodium-coupled sulphate, di- and tri-carboxylate transportersREACTOMER-HSA-433137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
243518562014An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka.25
186029832008Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1.16
155619732005Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions.14
163316472006Identification of basolateral membrane targeting signal of human sodium-dependent dicarboxylate transporter 3.9
218652622011Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3.8
218736652011PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3.8
270536892016Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron.6
208131242010High-affinity Na(+)-dependent dicarboxylate cotransporter promotes cellular senescence by inhibiting SIRT1.3
242471552013Glutathione is a low-affinity substrate of the human sodium-dependent dicarboxylate transporter.2
253549432014Transporters involved in renal excretion of N-carbamoylglutamate, an orphan drug to treat inborn n-acetylglutamate synthase deficiency.1

Citation

Dessen P

SLC13A3 (solute carrier family 13 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73279/slc13a3